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| CAS No.: | 16475-90-4 |
|---|---|
| Name: | METHYL 5-ACETYLSALICYLATE |
| Article Data: | 18 |
| Molecular Structure: | |
|
|
|
| Formula: | C10H10O4 |
| Molecular Weight: | 194.187 |
| Synonyms: | 5-Acetyl-2-hydroxybenzoic acidmethyl ester;Salicylicacid, 5-acetyl-, methyl ester (6CI,7CI,8CI);Methyl 3-acetyl-6-hydroxybenzoate;Methyl5-acetyl-2-hydroxybenzoate;NSC 67867;Methyl2-hydroxy-5-acetylbenzoate;5-Acetylsalicylic acid methyl ester; |
| EINECS: | 240-532-2 |
| Density: | 1.234 g/cm3 |
| Melting Point: | 62-64 °C(lit.) |
| Boiling Point: | 345.4 °C at 760 mmHg |
| Flash Point: | 138 °C |
| Appearance: | white to light yellow-orange crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 63.60000 |
| LogP: | 1.38140 |
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- 67-56-1
methanol
- 13110-96-8
5-acetylsalicylic acid
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With sulfuric acid for 24h; Heating; | 96% |
| With thionyl chloride at 65℃; for 24h; Inert atmosphere; |
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With ytterbium(III) triflate In isopropyl alcohol for 20h; Deacetylation; Heating; | 95% |
- 108-24-7
acetic anhydride
- 119-36-8
methyl salicylate
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With aluminium trichloride In dichloromethane for 3h; Friedel-Crafts reaction; | 93% |
| With aluminum (III) chloride In dichloromethane at -5 - 10℃; for 20h; Inert atmosphere; | 83.3% |
| With aluminum (III) chloride In nitrobenzene at 120 - 180℃; for 0.133333h; Temperature; Time; Pressure; Friedel-Crafts Acylation; Microwave irradiation; | 100 %Chromat. |
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With ytterbium(III) triflate In nitromethane for 1h; Ambient temperature; | 74% |
- 72554-64-4
3-acetyl-3',3'-dicyano-5-methoxycarbonylxanthyrone
A
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
B
- 99-93-4
4-Hydroxyacetophenone
| Conditions | Yield |
|---|---|
| With water for 3h; Product distribution; Heating; other xanthyrones; | A 41% B 16% |
- 72554-63-3
3-acetyl-3'-cyano-3',5-bismethoxycarbonylxanthyrone
A
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
B
- 99-93-4
4-Hydroxyacetophenone
| Conditions | Yield |
|---|---|
| With water for 3h; Product distribution; Heating; other xanthyrones; | A 41% B 16% |
| Conditions | Yield |
|---|---|
| With PPA at 80℃; for 2h; | 20% |
- 580-02-9
methyl acetylsalicylate
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With aluminium trichloride; nitrobenzene |
- 606-45-1
2-methoxybenzoic acid methyl ester
- 75-36-5
acetyl chloride
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With carbon disulfide; aluminium trichloride |
- 74823-33-9, 78075-03-3
3'-acetyl-3,5,5'-trismethoxycarbonylglaucyrone
- 16475-90-4
estere metilico dell'acido 5-acetilsalicilico
| Conditions | Yield |
|---|---|
| With water for 3h; Product distribution; Heating; other glaucyrones; |
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Chemistry
Molecular Structure:
Molecular Formula: C10H10O4
Molecular Weight: 194.184
IUPAC Name: Methyl 5-acetyl-2-hydroxybenzoate
Synonyms of Methyl 5-acetylsalicylate (CAS NO.16475-90-4): EINECS 240-532-2 ; Benzoic acid, 5-acetyl-2-hydroxy-, methyl ester ; 5-Acetylsalicylic acid methyl ester ; 5-Acetyl-2-hydroxybenzoic acid methyl ester ; 5-Acetyl 2-methylsalicylate ; Methyl 2-hydroxy-5-acetylbenzoate ; Methyl 5-acetyl-2-hydroxybenzoate
CAS NO: 16475-90-4
Classification Code: Aromatic Esters ; Esters ; Phenyls & Phenyl-Het ; Phenyls & Phenyl-Het ; C10 to C11 ; Carbonyl Compounds
Melting point: 62-64 °C
Index of Refraction: 1.547
Molar Refractivity: 49.93 cm3
Molar Volume: 157.2 cm3
Surface Tension: 47.2 dyne/cm
Density: 1.234 g/cm3
Flash Point: 138 °C
Enthalpy of Vaporization: 61.27 kJ/mol
Boiling Point: 345.4 °C at 760 mmHg
Vapour Pressure: 3.1E-05 mmHg at 25°C
Uses
Methyl 5-acetylsalicylate (CAS NO.16475-90-4) is used as a pharmaceutical intermediate.
Safety Profile
Hazard Codes of Methyl 5-acetylsalicylate (CAS NO.16475-90-4): 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3