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| CAS No.: | 165800-03-3 |
|---|---|
| Name: | Linezolid |
| Article Data: | 98 |
| Molecular Structure: | |
|
|
|
| Formula: | C16H20FN3O4 |
| Molecular Weight: | 337.351 |
| Synonyms: | Acetamide,N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-, (S)-;(S)-Linezolid;Linospan;Linox;N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;PNU 100766;U 100766;Zyvox; |
| EINECS: | 605-416-1 |
| Density: | 1.302 g/cm3 |
| Melting Point: | 176-178 °C |
| Boiling Point: | 585.5 °C at 760 mmHg |
| Flash Point: | 307.9 °C |
| Appearance: | White solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22 |
| Safety: | 36 |
| PSA: | 71.11000 |
| LogP: | 1.64450 |
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- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With ammonium hydroxide In methanol at 20 - 25℃; for 12h; | 98% |
- 1609632-44-1
N-(3-(3-fluoro-4-(morpholin-4-yl)phenyl)-2-oxooxazolidin-5(S)-ylmethyl)amine benzoate
- 108-24-7
acetic anhydride
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| In dichloromethane at 20 - 24℃; | 97% |
- 32315-10-9
bis(trichloromethyl) carbonate
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane at 0 - 20℃; for 2h; | 95% |
| With triethylamine In dichloromethane at 0 - 20℃; for 2h; | 95% |
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With triethylamine; dicyclohexyl-carbodiimide In acetonitrile at 80℃; Reagent/catalyst; Solvent; Temperature; | 94.2% |
- 75-36-5
acetyl chloride
- 168828-90-8
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With triethylamine In ethyl acetate at 20℃; for 2h; | 92.8% |
| With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 85% |
| With triethylamine In dichloromethane at 20℃; Inert atmosphere; | 73 mg |
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With water; potassium carbonate In ethyl acetate at 60 - 65℃; | 92% |
| Stage #1: [(S)-N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide dihydrochloride With potassium carbonate In water; ethyl acetate at 60 - 65℃; Stage #2: In toluene at 20 - 100℃; | 92% |
| With sodium hydroxide In water at 0 - 2℃; |
| Conditions | Yield |
|---|---|
| With N,N-dimethyl-formamide at 50℃; Temperature; Inert atmosphere; | 92% |
- 565176-83-2
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
- 183905-31-9
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With lithium; tert-butyl alcohol In tetrahydrofuran; N,N-dimethyl acetamide; isopropyl alcohol at 0 - 20℃; Reagent/catalyst; Solvent; Concentration; | 90.3% |
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In methanol at 55℃; Concentration; Temperature; Heating; Industrial scale; | 90.2% |
- 168828-84-0
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
- 507-09-5
thioacetic acid
- 165800-03-3
linezolid
| Conditions | Yield |
|---|---|
| Stage #1: (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one; tiolacetic acid at 23℃; for 7h; Stage #2: With potassium hydroxide In water at 23℃; | 90% |
| at 23℃; for 7h; Inert atmosphere; | 90% |
| Ambient temperature; | 86% |
| at 20℃; for 15h; | 85% |
| at 20℃; for 15h; |
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Chemistry
Molecular Structure of Acetamide,N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- (CAS NO.165800-03-3):
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IUPAC Name: N-[[(5R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
Molecular Weight: 337.346103 [g/mol]
Molecular Formula: C16H20FN3O4
XLogP3-AA: 0.7
H-Bond Donor: 1
H-Bond Acceptor: 6
Index of Refraction: 1.553
Molar Refractivity: 82.96 cm3
Molar Volume: 259 cm3
Surface Tension: 47.7 dyne/cm
Density: 1.302 g/cm3
Flash Point: 307.9 °C
Enthalpy of Vaporization: 87.47 kJ/mol
Boiling Point: 585.5 °C at 760 mmHg
Vapour Pressure: 1.08E-13 mmHg at 25 °C
Appearance: White Solid
Melting Point: 176-178 °C
Classification Code: Anti-Infective Agents; Antibacterial; Enzyme Inhibitors; Protein Synthesis Inhibitors
Product Categories: Antibacterial; Aromatics Compounds; Aromatices; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Uses
Acetamide,N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- (CAS NO.165800-03-3) is used as prototype of the oxazolidinone antimicrobials and inhibits bacterial mRNA translation.
Safety Profile
Safety Information of Acetamide,N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- (CAS NO.165800-03-3):
Hazard Codes: 
Xn
Risk Statements: 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
Specification
Acetamide,N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- (CAS NO.165800-03-3), its Synonyms are Linezolid ; N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide ; Zivoxid ; Zyvox ; Acetamide, N-((3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-, (S)- .