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166432-28-6

Basic Information
CAS No.: 166432-28-6
Name: Clevidipine
Article Data: 10
Molecular Structure:
Molecular Structure of 166432-28-6 (Clevidipine)
Formula: C21H23Cl2NO6
Molecular Weight: 456.32
Synonyms: levidipine;
EINECS: 814-032-5
Density: 1.289 g/cm3
Boiling Point: 539.7 °C at 760 mmHg
Flash Point: 280.2 °C
Appearance: White crystalline powder
PSA: 90.93000
LogP: 4.57400
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  • 166432-28-6

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    166432-28-6

    166432-28-6

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    Nanjing Chemlin Chemical Industry Co., Ltd was established in Aug,1999, located in the industrial park of Nanjing University of Technology, It is a private enterprises in Jiangsu Province with 1200 square meters’ R&D center. Our R&D center has a well

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  • (-)-R-Clevidipine,166432-28-6

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    166432-28-6

    (-)-R-Clevidipine,166432-28-6

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    Superiority: 1. Quality: High purity, strict quality control, 10 years experience in chemical industry. 2. Price: Moderate price, more QTY more discount. 3. MOQ: Sample order is welcome to test quality. 4. Shipping time: In Stock, can b

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  • Clevidipine

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    Clevidipine

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    Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Complete

    Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemica

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  • Clevidipine

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    166432-28-6

    Clevidipine

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    Enterprice standard Application:Antihypertensive pharmaceutical raw ma...

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Specification

The Clevidipine, with the CAS registry number 166432-28-6, is also known as Clevidipine butyrate. This chemical's molecular formula is C21H23Cl2NO6 and molecular weight is 456.316. Its IUPAC name is called O3-(butanoyloxymethyl) O5-methyl (4R)- 4-(2,3-dichlorophenyl)-2,6-dimethyl- 1,4-dihydropyridine-3,5-dicarboxylate.

Physical properties of Clevidipine: (1)ACD/LogP: 5.46; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.46; (4)ACD/LogD (pH 7.4): 5.46; (5)ACD/BCF (pH 5.5): 8354.18; (6)ACD/BCF (pH 7.4): 8361.5; (7)ACD/KOC (pH 5.5): 22324.42; (8)ACD/KOC (pH 7.4): 22343.96; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.542; (13)Molar Refractivity: 111.45 cm3; (14)Molar Volume: 353.8 cm3; (15)Surface Tension: 44.2 dyne/cm; (16)Density: 1.289 g/cm3; (17)Flash Point: 280.2 °C; (18)Enthalpy of Vaporization: 81.72 kJ/mol; (19)Boiling Point: 539.7 °C at 760 mmHg; (20)Vapour Pressure: 1.03E-11 mmHg at 25°C.

Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Cleviprex is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or cardiac conduction. Cleviprex is rapidly metabolized by esterases in the blood and extravascular tissues. Cleviprex is available in ready-to-use 50- and 100-mL glass vials at a concentration of 0.5 mg/mL of clevidipine butyrate. Vials should be refrigerated at 2-8oC (36-46°F). Cleviprex can be stored to controlled room temperature for up to 2 months.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCOC(=O)CCC)\C1=C(\N/C(=C(/C(=O)OC)C1c2cccc(Cl)c2Cl)C)C
(2)InChI: InChI=1/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
(3)InChIKey: KPBZROQVTHLCDU-UHFFFAOYAA