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| CAS No.: | 16709-25-4 |
|---|---|
| Name: | ALPHA-METHYL-L-TRYPTOPHAN |
| Article Data: | 10 |
| Molecular Structure: | |
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|
|
| Formula: | C12H14N2O2 |
| Molecular Weight: | 218.255 |
| Synonyms: | Tryptophan,α-methyl-, L- (8CI);(-)-α-Methyltryptophan;L-α-Methyltryptophan;α-Methyl-(S)-tryptophan;α-Methyl-L-tryptophan; |
| Density: | 1.314 g/cm3 |
| Melting Point: | 168-172 °C |
| Boiling Point: | 444 °C at 760 mmHg |
| Flash Point: | 222.3 °C |
| Appearance: | Colourless solid |
| PSA: | 79.11000 |
| LogP: | 2.13100 |
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- 114524-80-0
methyl 2-(indol-3-ylmethyl)-2-aminopropionate
A
- 56452-52-9
α-methyl-DL-tryptophan
B
- 16709-25-4
(S)-α-methyltryptophan
C
- 96551-27-8
α-methyl-(R)-tryptophan methyl ester
| Conditions | Yield |
|---|---|
| With α-chymotrypsin In water at 37℃; for 40h; pH=5.0; | A 4% B n/a C 88% |
| With α-chymotrypsin In water at 37℃; for 40h; pH=5.0; | A 4% B n/a C n/a |
- 114524-80-0
methyl 2-(indol-3-ylmethyl)-2-aminopropionate
A
- 16709-25-4
(S)-α-methyltryptophan
B
- 96551-27-8
α-methyl-(R)-tryptophan methyl ester
| Conditions | Yield |
|---|---|
| With α-chymotrypsin In water at 37℃; for 40h; Product distribution; also other α-methyl-amino acid esters investigated; | A n/a B 88% |
- 116139-87-8
(S)-N2-benzoyl-2-methyltryptophan-methylester
- 16709-25-4
(S)-α-methyltryptophan
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol Heating; | 87% |
- 1266681-04-2
tert-butyl 3-{[(3S,5aR,6aS,7aS)-2,3,5,5a,6,6a,7,7a-octahydro-3,6,6,7a-tetramethyl-2-oxobicyclo[4.1.0]hept-1(6)eno[3,4-b][1,4]oxazin-3-yl]methyl}-1H-indole-1-carboxylate
- 16709-25-4
(S)-α-methyltryptophan
| Conditions | Yield |
|---|---|
| Stage #1: tert-butyl 3-{[(3S,5aR,6aS,7aS)-2,3,5,5a,6,6a,7,7a-octahydro-3,6,6,7a-tetramethyl-2-oxobicyclo[4.1.0]hept-1(6)eno[3,4-b][1,4]oxazin-3-yl]methyl}-1H-indole-1-carboxylate With cesium hydroxide; water In ethanol at 70℃; for 4h; Stage #2: With hydrogenchloride In water | 86% |
- 16709-25-4
(S)-α-methyltryptophan
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 150℃; for 72h; Hydrolysis; | 40% |
- 141784-94-3
2-Amino-3-(1H-indol-3-yl)-2-methyl-propionic acid butyl ester
A
- 16709-25-4
(S)-α-methyltryptophan
B
- 141784-97-6
(R)-2-Amino-3-(1H-indol-3-yl)-2-methyl-propionic acid butyl ester
C
- 141784-94-3, 141784-97-6
(S)-2-Amino-3-(1H-indol-3-yl)-2-methyl-propionic acid butyl ester
| Conditions | Yield |
|---|---|
| In various solvent(s) Ambient temperature; Candida lipolythica lipase (active component: Candida lypolythica esterase); Yield given. Yields of byproduct given; | |
| In various solvent(s) Ambient temperature; Candida lipolythica lipase (active component: Candida lypolythica esterase); Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 121704-33-4
2-(2-Chloro-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionic acid
A
- 16709-25-4
(S)-α-methyltryptophan
B
- 121704-33-4
(R)-2-(2-Chloro-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionic acid
| Conditions | Yield |
|---|---|
| With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2; |
A
- 56452-52-9
α-methyl-DL-tryptophan
B
- 16709-25-4
(S)-α-methyltryptophan
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 16h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 16709-25-4
(S)-α-methyltryptophan
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethanol for 3h; Ambient temperature; Yield given; |
| Conditions | Yield |
|---|---|
| resolution of racemate via chiral HPLC; | |
| With Merck RP-18 WF254S plates coated with Nτ-n-decyl-L-spinacine and Cu acetate In water; acetonitrile Resolution of racemate; |
- Total:19 Page 1 of 1 1
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Specification
The CAS register number of L-Tryptophan,α-methyl- is 16709-25-4. It also can be called as L-α-Methyltryptophan and the systematic name about this chemical is α-methyl-L-tryptophan. The molecular formula about this chemical is C12H14N2O2 and the molecular weight is 218.25. It belongs to the following product categories which include Amino Acids 13C, 2H, 15N; Amino Acids & Derivatives; Chiral Reagents; Heterocycles; Indole Derivatives and so on. The usage of this chemical is a therapeutic and carrier molecule.
Physical properties about L-Tryptophan,α-methyl- are: (1)ACD/LogP: 1.39; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 4; (7)#H bond donors: 4; (8)#Freely Rotating Bonds: 4; (9)Polar Surface Area: 34.47 Å2; (10)Index of Refraction: 1.675; (11)Molar Refractivity: 62.4 cm3; (12)Molar Volume: 166 cm3; (13)Polarizability: 24.74x10-24cm3; (14)Surface Tension: 65.7 dyne/cm; (15)Density: 1.314 g/cm3; (16)Flash Point: 222.3 °C; (17)Enthalpy of Vaporization: 73.96 kJ/mol; (18)Boiling Point: 444 °C at 760 mmHg; (19)Vapour Pressure: 1.15E-08 mmHg at 25 °C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)[C@](N)(C)Cc2c1ccccc1nc2
(2)InChI: InChI=1/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)/t12-/m0/s1
(3)InChIKey: ZTTWHZHBPDYSQB-LBPRGKRZBW
(4)Std. InChI: InChI=1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)/t12-/m0/s1
(5)Std. InChIKey: ZTTWHZHBPDYSQB-LBPRGKRZSA-N