Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 171489 > 

171489-59-1
Refine

Refine

Country

Business Type

Certificate

Display

Products Categories

Basic Information
CAS No.: 171489-59-1
Name: (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE
Molecular Structure:
Molecular Structure of 171489-59-1 ((1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE)
Formula: C22H19ClN2O5
Molecular Weight: 426.856
Synonyms: (1R,3R)-1-(1,3-BENZODIOXOL-5-YL)-2-(CHLOROACETYL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B] INDOLE-3-CARBOXYLIC ACID METHYL ESTER;(6R,12aR)-methyl1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate;(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-B]indole-3-carboxylic acid methyl ester;
Density: 1.445
Melting Point: 230-232 oC
Boiling Point: 627.5±55.0 °C(Predicted)
Solubility: Chloroform, DMSO, Ethyl Acetate, Methanol
Appearance: Pale Yellow to Pale Orange Solid
PSA: 80.86000
LogP: 3.08900
Related products
Synthetic route
79-04-9

chloroacetyl chloride

(1R,3R)-1-benzo[1,3]dioxol-5-yl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester hydrochloride

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 5 - 20℃; for 1.66667h; Product distribution / selectivity;97%
Stage #1: (1R,3R)-1-benzo[1,3]dioxol-5-yl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester hydrochloride With triethylamine In tetrahydrofuran; water at 0 - 20℃;
Stage #2: chloroacetyl chloride In tetrahydrofuran; water at 0 - 10℃; for 2h;		95%
With triethylamine In tetrahydrofuran; water at 0 - 10℃; for 2h; Inert atmosphere;93%
79-04-9

chloroacetyl chloride

171596-41-1

(1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Stage #1: (1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate With triethylamine In dichloromethane at 20℃; for 0.166667h; Large scale;
Stage #2: chloroacetyl chloride In dichloromethane at 20℃; for 1h; Large scale;		95.2%
With potassium carbonate In dichloromethane; ethyl acetate at 5 - 20℃;94%
With sodium hydrogencarbonate In chloroform at 20℃;93%
120-57-0

piperonal

14907-27-8, 5619-09-0, 7524-52-9, 26988-71-6, 41222-70-2, 67557-19-1, 109492-62-8

(R)-(+)-tryptophan methyl ester hydrochloride

79-04-9

chloroacetyl chloride

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Stage #1: piperonal; (R)-(+)-tryptophan methyl ester hydrochloride at 85℃; for 3h;
Stage #2: chloroacetyl chloride With triethylamine In tetrahydrofuran; water at 0 - 10℃; for 1h; Product distribution / selectivity;		86%
...Expand
79-04-9

chloroacetyl chloride

(R)-2-{[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-amino}-3-(1H-indol-3-yl)-propionic acid methyl ester

A

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

B

629652-40-0

(1S,3R)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h; N-acyliminium Pictet-Spengler reaction;A 43%
B 34%
...Expand
120-57-0

piperonal

isooxyurea

isooxyurea

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 23 percent / trifluoroacetic acid / CH2Cl2 / 24 h / 20 °C
2: 83 percent / triethylamine / CHCl3 / -10 °C
View Scheme
14907-27-8, 5619-09-0, 7524-52-9, 26988-71-6, 41222-70-2, 67557-19-1, 109492-62-8

(R)-(+)-tryptophan methyl ester hydrochloride

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 23 percent / trifluoroacetic acid / CH2Cl2 / 24 h / 20 °C
2: 83 percent / triethylamine / CHCl3 / -10 °C
View Scheme
Multi-step reaction with 2 steps
1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C
2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / aq.HCl / methanol / 36 h / Heating
2: 78 percent / NaHCO3 / CH2Cl2; H2O
View Scheme
120-57-0

piperonal

rhodaninoic acid

rhodaninoic acid

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C
2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / aq.HCl / methanol / 36 h / Heating
2: 78 percent / NaHCO3 / CH2Cl2; H2O
View Scheme
Multi-step reaction with 2 steps
1: 95 percent / Et3N; MgSO4 / CH2Cl2 / 24 h
2: 43 percent / DMAP / CH2Cl2 / 2 h / 20 °C
View Scheme
120-57-0

piperonal

glycocoll ester

glycocoll ester

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 42 percent / TFA / CH2Cl2 / 20 °C
2: 93 percent / NaHCO3 / CHCl3 / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: toluene / Heating
2: TFA
3: Et3N
View Scheme
4299-70-1, 7303-49-3, 22032-65-1

D-Tryptophan methyl ester

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 42 percent / TFA / CH2Cl2 / 20 °C
2: 93 percent / NaHCO3 / CHCl3 / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Molecular sieve
2: triethylamine / chloroform / -10 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water; toluene / 15 h / Reflux; Large scale
2.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Large scale
2.2: 1 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / 10 h / 70 - 80 °C / Large scale
2: triethylamine / chloroform / 2 h / 20 - 30 °C
View Scheme
749864-17-3

(R)-2-{[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-amino}-3-(1H-indol-3-yl)-propionic acid methyl ester

171489-59-1

methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA
2: Et3N
View Scheme
Hot Products
  • Display:default sort

    New supplier

  • Tadanafil N-I intermediate Manufacturer/CAS:171489-59-1Chinese suppliers

  • Casno:

    171489-59-1

    Tadanafil N-I intermediate Manufacturer/CAS:171489-59-1Chinese suppliers

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 1.0-2.0

    Name: Tadanafil N-I intermediate English Name: Tadanafil N-I intermediate CAS No. 171489-59-1 Molecular formula: C22H19ClN2O5 Packaging Specification: 25kg/drum high purity 99%min stock Hubei DiBo Chemical Co., Ltd. was founded in 2009, is

    Hubei DiBo chemical co., LTD Hubei DiBo Chemical Co., Ltd. was founded in 2009, is located in Hubei Province on both sides of the Yangtze River, one of the ancient cities of Chines

  •  Hubei DiBo chemical co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86 15871366807

    Address:No. 782 of wuchang district of wuhan city, hubei province

       Inquiry Now

  • High quality Tadalafil intermediate Cas 171489-59-1 with favorable price and fast delivery

  • Casno:

    171489-59-1

    High quality Tadalafil intermediate Cas 171489-59-1 with favorable price and fast delivery

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Unique advantages for Tadalafil intermediate Cas 171489-59-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Off-white powder Storage:-20°C Freezer Package:1kg/foil bag;25kg/

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207852

    Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China

       Inquiry Now

  • Chloropretadalafil

  • Casno:

    171489-59-1

    Chloropretadalafil

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech bio chemical products enterprises. The company's

  •  Shanghai Seasonsgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86 156 1855 4368

    Address:No.12, Lane 356, Chengnan Road, Chuansha Town, Shanghai

       Inquiry Now

  • (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE

  • Casno:

    171489-59-1

    Urolithin B CAS NO.171489-59-1 99%HPLC White powder_LYNA Bio

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Product Details(14+years experience in health industry)： Name:LYNA Supply High quality Factory price CAS NO.: MOQ:1 Kilogram Shelf Life.24 Months Key word: Our Advantages as blow: 1)Professional team-Management andprofessional technical team 2)Good

    Xi'an Lyna Bio-Tech Co., Ltd. is a leading plant extracts and herbal medicine manufacturer, located in Chang'an District, Xi'an, Shaanxi Province, China. It is a modern high-tech c

  •  Xi'an Lyna Bio-Tech Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86--18629577295

    Address:Room 1502, Unit 3, Building 2, Nanshan Garden, Guodu Street, Chang 'an District, Xi 'an, Shaanxi Province

       Inquiry Now

  • Pharmaceutical Grade CAS 171489-59-1 with competitive price

  • Casno:

    171489-59-1

    Pharmaceutical Grade CAS 171489-59-1 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is （Wen Xi Pharma）, including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO 171489-59-1

  • Casno:

    171489-59-1

    (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO cas:171489-59-1

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 15.0-50.0

    Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

    Hebei Dangtong Biological Technology Co.,LTD was established in August 2021. It currently has more than 20 employees. Our factory currently has more than 500 employees. The company

  •  Hebei Dangtong Biological Technology Co..LTD

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-139-10575315

    Address:No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province

       Inquiry Now

  • Chloropretadalafil

  • Casno:

    171489-59-1

    Chloropretadalafil

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Our product has a very high quality and now we are exporting to customers overseas with very positive feedback. With best price, quality and service from Nanjing Sunny, we are confident to set up a very nice cooperation with customers all over the w

    Welcome to Sunny Pharmatech! Nanjing Sunny pharmatech Co., Ltd is a manufacturer and supplier of raw materials and ingredients for food and healthy supplement products, intermediat

  •  NANJING SUNNY PHARMATECH CO., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-13814179829

    Address:No. 1704 SHUANGLONOG AVENUE, NANJING, CHINA

       Inquiry Now

  • Chloropretadalafil

  • Casno:

    171489-59-1

    Chloropretadalafil

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Hello, dear friend! Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time. product quality 1.The product quality h

    Suzhou senfeida Chemical Co., Ltd. is located in Hushuguan economic and Technological Development Zone, Suzhou high tech Zone. It is a civilian chemical enterprise that produces an

  •  Suzhou Senfeida Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:186-624-33356

    Address:Hushuguan Economic and Technological Development Zone, Suzhou High-tech Zone

       Inquiry Now

  • Tadalafil Intermediates

  • Casno:

    171489-59-1

    Tadalafil Intermediates

    Min.Order: 100 Gram

    FOB Price:  USD $ 1.9-2.9

    Appearance:liquid Storage:Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. Package:Grams, Kilograms Application:For R&D and commerical use Transportati

    We are a team of industry experts, dedicated to delivering the best chemical solutions from quality suppliers across China. Putting our customers first, we take a holistic approach

  •  Chemlyte Solutions

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-189 8945 5137

    Address:Jian Qiao Community, 789 Shenhua Road, Xihu District, Hangzhou, China, 310000

       Inquiry Now

  • Tadalafil Intermediate

  • Casno:

    171489-59-1

    Tadalafil Intermediate

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

    Our company was funded in 2012. We are speciallized in personal care raw materials including cosmetic, dyes, Colorant, Surfactant...We are committed to serving small and medium buy

  •  Hangzhou Fonlynn Health Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86 13291832373

    Address:Room 622, Building 11, Yifeng City, Nanyuan Street, Yuhang District

       Inquiry Now

  • Chloropretadalafil

  • Casno:

    171489-59-1

    Chloropretadalafil

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    1)Professional team-Management and professional technical team 2)Good quality:Provide high quality products 3)OEM&ODM-OEM and ODM generation processing are warmly welcomed 4)After sale-Sincerely servesevery customer with 24 hours. 5)Delivery Time

    SYNTAME is a national level technology oriented enterprise that focuses on the R&D, production and sales of API and pharma-intermediates. It is committed to process R&D of original

  •  Ningbo Syntame Biotech Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-574-28802872

    Address:No. 2 Building of Ruiding accelerator，No. 789, Xiaying North Road, Ningbo, Zhejiang

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 171489-59-1

Specification

An intermediate in the synthesis of Tadalafil, which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.