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CAS No.: | 17447-35-7 | ||||
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Name: | (+)-4'-CHLOROTARTRANILIC ACID | ||||
Article Data: | 2 | ||||
Cas Database | |||||
Molecular Structure: | |||||
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Formula: | C10H10 Cl N O5 | ||||
Molecular Weight: | 259.646 | ||||
Synonyms: | Butanoicacid, 4-[(4-chlorophenyl)amino]-2,3-dihydroxy-4-oxo-, [R-(R*,R*)]-; Tartranilicacid, 4'-chloro-, (2R,3R)-(+)- (8CI); L-Tartaric acid p-chloroanilide | ||||
Density: | 1.644g/cm3 | ||||
Melting Point: | 193 °C | ||||
Boiling Point: | 609.1°Cat760mmHg | ||||
Flash Point: | 322.2°C | ||||
Risk Codes: | 36/37/38 | ||||
Safety: |
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PSA: | 106.86000 | ||||
LogP: | 0.15790 |
4-chloro-aniline
(3R-trans)-dihydro-2,5-dioxofuran-3,4-diyl diacetate
(R,R)-(+)-4-chlorotartranilic acid
Conditions | Yield |
---|---|
In dichloromethane for 15h; Heating; | 68% |
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
(R,R)-(+)-4-chlorotartranilic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water at 60 - 70℃; Solvent; Resolution of racemate; Heating; | 92% |
3-hydroxypiperazine
(R,R)-(+)-4-chlorotartranilic acid
Conditions | Yield |
---|---|
In ethanol at 40℃; | 74% |
(+/-)-5-(4-amino-3-methylphenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
(R,R)-(+)-4-chlorotartranilic acid
(S)-(-)-5-(4-amino-3-methylphenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine salt with L-tartaric acid semi-4-chloroanilide
Conditions | Yield |
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In ethanol at 20℃; for 20h; Heating / reflux; | 36% |
(R,R)-(+)-4-chlorotartranilic acid
Apremilast
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 60 - 70 °C / Resolution of racemate; Heating 2: acetic acid / 24 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: chloroform / Heating; Resolution of racemate 2: acetic acid / 24 h / Reflux View Scheme |
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
(R,R)-(+)-4-chlorotartranilic acid
Conditions | Yield |
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In chloroform Solvent; Heating; Resolution of racemate; Overall yield = 94 %; | A n/a B n/a |