CAS No.19216-56-9,Prazosin Suppliers

Products Categories

Pharmaceutical (34)
Organic Chemicals (10)
Others (8)
Reagent (2)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	19216-56-9
Name:	Prazosin
Article Data:	19

Formula:	C₁₉H₂₁N₅O₄
Molecular Weight:	383.407
Synonyms:	Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI);Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI);4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone;Furazosin;Lentopres;
EINECS:	242-885-8
Density:	1.353 g/cm³
Melting Point:	278-280°C
Boiling Point:	638.366 °C at 760 mmHg
Flash Point:	339.871 °C
Solubility:	3.2mg/L(22.5 oC)
PSA:	106.95000
LogP:	3.17070

Total:50 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 19216-56-9

Chemistry

IUPAC Name: [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
The MF of Prazosin (CAS NO.19216-56-9) is C₁₉H₂₁N₅O₄.

The MW of Prazosin (CAS NO.19216-56-9) is 383.4.
Synonyms of Prazosin (CAS NO.19216-56-9): [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone ; 1-(4-Amino-6, 7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride
Apperance: Crystallization
Index of Refraction: 1.651
EINECS: 242-885-8
Density: 1.352 g/ml
Flash Point: 339.9 °C
Boiling Point: 638.4 °C
Melting Point: 278-280 °C

Uses

Prazosin (CAS NO.19216-56-9) is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity.it is a second-line choice for the treatment of high blood pressure.Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia by blocking alpha-1 receptors, which control constriction of both the prostate and ureters.This medication has shown to be effective in treating severe nightmares in children, associated with PTSD symptoms.

Production

3,4-Dimethoxy--6-amino-benzonitrile generated 3,4-dimethoxy-6-Thiocyanate acyl benzonitrile in water and dichloromethane and sulfur anal phosgene (yield is 94% ).It would get thiourea derivative by reacted with 1-(2-furan-carbonyl)-piperazine in ethyl acetate(yield is 90%). Then derived free S-methyl-isothiourea derivatives by methylated with methyl iodide to the reaction with the alkali treatment(yield is 95%). Finally,formamide prazosin was gotten by the reaction of S-methyl isothiourea biological, ammonia, ammonium chloride and urea.

Toxicity Data With Reference

1.	orl-wmn TDLo:20 µg/kg:BPR,GIT	AIMEAS Annals of Internal Medicine. 97 (1982),455.
2.	orl-man TDLo:1143 µg/kg:BPR	AMSVAZ Acta Medica Scandinavica. 213 (1983),157.
3.	orl-hmn TDLo:280 µg/kg:CNS,CVS	BMJOAE British Medical Journal. 2 (1976),508.
4.	orl-hmn TDLo:1260 µg/kg:CNS,KID	BMJOAE British Medical Journal. 1 (1978),622.

Safety Profile

Human systemic effects by ingestion of very small amounts: somnolence, hallucinations, distorted perceptions, changes in motor activity, decreased blood pressure, nausea or vomiting, and kidney effects. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Prazosin is a sympatholytic drug used to treat high blood pressure (hypertension). It belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Specifically, prazosin is selective for the alpha-1 receptors on vascular smooth muscle. These receptors are responsible for the vasoconstrictive action of norepinephrine, which would normally raise blood pressure. By blocking these receptors, prazosin reduces blood pressure.