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| CAS No.: | 19524-06-2 |
|---|---|
| Name: | 4-Bromopyridine hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C5H4BrN.HCl |
| Molecular Weight: | 194.458 |
| Synonyms: | 4-Bromopyridinium chloride;4-Bromopyridine HCl; |
| EINECS: | 243-128-4 |
| Density: | 1.598 g/cm3 |
| Melting Point: | 270 °C (dec.)(lit.) |
| Boiling Point: | 185.2 °C at 760 mmHg |
| Flash Point: | 65.8 °C |
| Solubility: | Soluble in DMSO, Methanol and Water. |
| Appearance: | White crystalline powder |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | 36/37/38-20/21/22 |
| Safety: | 26-36/37/39-22 |
| Transport Information: | 2811 |
| PSA: | 12.89000 |
| LogP: | 2.64610 |
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- 211914-50-0N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride
- 240444-70-62,3,5,6-Tetrafluor-4-(methoxymethyl)benzyl-2,2-dimethyl-3-(prop-1-en-1-yl)cyclopropancarboxylat
- 87199-17-5
4-formylphenylboronic acid,
- 19524-06-2
4-bromopyridine hydrochloride
- 99163-12-9
4-(pyridin-4-yl)benzaldehyde
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water for 4h; Suzuki Coupling; Reflux; Inert atmosphere; | 100% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; isopropyl alcohol; toluene for 7h; Inert atmosphere; Reflux; | 94% |
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; isopropyl alcohol; toluene for 7h; Inert atmosphere; Reflux; | 84% |
- 19524-06-2
4-bromopyridine hydrochloride
- 1120-87-2
4-bromopyridin
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 20℃; for 6h; Inert atmosphere; Schlenk technique; | 100% |
| With sodium hydroxide In water at 20℃; for 0.166667h; | 100% |
| With sodium hydrogencarbonate In water | 84% |
- 91983-26-5
4-(cyanomethyl)phenylboronic acid
- 19524-06-2
4-bromopyridine hydrochloride
- 112170-33-9
2-(4-(pyridin-4-yl)phenyl)acetonitrile
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; isopropyl alcohol; toluene for 7h; Inert atmosphere; Reflux; | 100% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; isopropyl alcohol; toluene for 7h; Inert atmosphere; Reflux; | 61% |
| Stage #1: 4-(cyanomethyl)phenylboronic acid; 4-bromopyridine hydrochloride With potassium carbonate In isopropyl alcohol; toluene at 20℃; for 0.5h; Inert atmosphere; Stage #2: With tetrakis(triphenylphosphine) palladium(0) for 7h; Inert atmosphere; Reflux; |
- 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
- 19524-06-2
4-bromopyridine hydrochloride
- 1587730-27-5
[RuCl2(p-cymene)(4-BrNC5H4)]
| Conditions | Yield |
|---|---|
| In dichloromethane at 20℃; | 100% |
| In dichloromethane at 20℃; | 97% |
- 19524-06-2
4-bromopyridine hydrochloride
- 147081-44-5
(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine
- 1010446-43-1
(S)-3-(pyridin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
| Conditions | Yield |
|---|---|
| With sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 70℃; for 4h; | 99% |
- 19524-06-2
4-bromopyridine hydrochloride
- 927-74-2
1-butyn-4-ol
- 192643-83-7
4-(pyridin-4-yl)butyl-3-yn-1-ol
| Conditions | Yield |
|---|---|
| With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine; lithium chloride In water for 2h; Sonogashira coupling; Reflux; Inert atmosphere; | 99% |
- 1032189-97-1
3,5-dimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl diethylcarbamate
- 19524-06-2
4-bromopyridine hydrochloride
- 1032189-92-6
3,5-dimethoxy-2-(pyridin-4-yl)phenyl diethylcarbamate
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 90℃; for 20h; Suzuki-Miyaura coupling; | 99% |
- 5720-05-8
4-methylphenylboronic acid
- 19524-06-2
4-bromopyridine hydrochloride
- 4423-10-3
4-(p-tolyl)pyridine
| Conditions | Yield |
|---|---|
| With Pd(PPh2)(m-C6H4SO3Na)*(H2O)4; sodium carbonate In methanol; water; benzene at 80℃; for 6.5h; | 98% |
| With palladium diacetate; sodium hydrogencarbonate; triphenylphosphine In water; N,N-dimethyl-formamide for 18h; Suzuki reaction; Heating; Inert atmosphere; | 80% |
- 6267-34-1
2-bromo-5-methoxy-1,3-dimethyl-benzene
- 19524-06-2
4-bromopyridine hydrochloride
- 338989-70-1
4-manisylpyridine
| Conditions | Yield |
|---|---|
| Stage #1: 2-bromo-5-methoxy-1,3-dimethyl-benzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: With zinc(II) chloride In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: 4-bromopyridine hydrochloride With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane for 12h; Negishi coupling; Heating; | 98% |
- 1429747-36-3
5-methoxy-2-[1-(4-methoxybenzyl)-1H-indazol-3-yl]pyrimidin-4-amine
- 19524-06-2
4-bromopyridine hydrochloride
- 1429745-32-3
5-methoxy-2-[1-(4-methoxybenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)-pyrimidin-4-amine
| Conditions | Yield |
|---|---|
| With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 105℃; Inert atmosphere; | 98% |
| With tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In N,N-dimethyl-formamide at 100℃; for 72h; Inert atmosphere; | 81% |
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Chemistry
IUPAC Name: 4-bromopyridine hydrochloride
Synonyms of 4-Bromopyridine hydrochloride (CAS NO.19524-06-2): Pyridine, 4-bromo-, hydrochloride ; 4-Bromopyridinium chloride
CAS NO: 19524-06-2
Molecular Formula: C5H4BrN.HCl
Molecular Weight: 194.46
Molecular Structure: 
EINECS: 243-128-4
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 12.89 Å2
Flash Point: 65.8 °C
Enthalpy of Vaporization: 40.41 kJ/mol
Boiling Point: 185.2 °C at 760 mmHg
Vapour Pressure: 0.968 mmHg at 25°C
Melting Point: 270 °C (dec.)(lit.)
Sensitive: Hygroscopic
Appearance: White crystalline powder
Product Categories: Pyridine;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridines derivates;Heterocyclic Compounds;Bromopyridines;Halopyridines;Pyridinium Compounds;Bases & Related Reagents;Nucleotides;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
Uses
4-Bromopyridine hydrochloride (CAS NO.19524-06-2) is a useful synthetic intermediate.
Safety Profile
Safety Information about 4-Bromopyridine hydrochloride (CAS NO.19524-06-2):
Hazard Codes: 
Xn,Xi
Risk Statements: 36/37/38-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-22
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2811
WGK Germany: 3
F: 3-10
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.