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| CAS No.: | 19767-45-4 |
|---|---|
| Name: | Mesna |
| Article Data: | 4 |
| Molecular Structure: | |
|
|
|
| Formula: | C2H5NaO3S2 |
| Molecular Weight: | 164.182 |
| Synonyms: | Uromitexan;Sodium 2-mercaptoethanesulfonate;Prestwick_1005;Ethanesulfonic acid,2-mercapto-,monosodium salt;Ethanesulfonic acid, 2-mercapto-, monosodium salt;Mesnaum;Mesna(19767-45-4);2-Mercaptoethanesulfonic Acid Sodium Salt;2-sulfanylethanesulfonic acid;Lomustine，Mesna; |
| EINECS: | 243-285-9 |
| Melting Point: | >240°C dec. |
| Solubility: | Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml). |
| Appearance: | white to off-white solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 104.38000 |
| LogP: | 0.54220 |
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sodium 2-bromethanesulfonate
- 19767-45-4
mesna
| Conditions | Yield |
|---|---|
| Stage #1: sodium 2-bromethanesulfonate With sodium hydroxide; tiolacetic acid In water at 10 - 105℃; for 2h; Heating / reflux; Stage #2: With acetic acid In water for 6h; Heating / reflux; |
- 19767-45-4
mesna
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water at 20 - 80℃; for 3h; Product distribution / selectivity; |
- 19767-45-4
mesna
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal; hydrogen at 50 - 60℃; under 7600.51 - 15201 Torr; for 1h; Autoclave; | 189 g |
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Chemistry
IUPAC Name: sodium 2-sulfanylethanesulfonate
Empirical Formula: C2H5NaO3S2
Molecular Weight: 164.1791g/mol
EINECS: 243-285-9
Structure of Mesna (CAS NO.19767-45-4):
Melting Point: >240°C dec
Stability: Stable. Incompatible with strong oxidizing agents.
Product Categories: Anti-Cancer;Pharmaceutical material and intermeidates;Xanthones;All Aliphatics;Antitumors for Research and Experimental Use;Biochemistry;Aliphatics;Sulfur & Selenium Compounds
Canonical SMILES: C(CS(=O)(=O)[O-])S.[Na+]
InChI: InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
InChIKey: XOGTZOOQQBDUSI-UHFFFAOYSA-M
Uses
Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo, may be converted to urotoxic metabolites .
Toxicity Data With Reference
| 1. | orl-rat LD50:4440 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 2. | ipr-rat LD50:1251 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 3. | ivn-rat LD50:1683 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 4. | orl-mus LD50:6102 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 5. | ipr-mus LD50:2005 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 6. | ivn-mus LD50:1887 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. | ||
| 7. | inv-dog LDLo:400 mg/kg | EJCODS European Journal of Cancer and Clinical Oncology. 18 (1982),1377. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: KI7968000
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFONATES and MERCAPTANS.
Specification
Mesna , its cas register number is 19767-45-4. It also can be called 2-Mercapto-ethan-sulfonsaeure, natrium-salz ; 2-Mercaptoethane sulfonate sodium ; 2-Mercaptoethanesulfonic acid monosodium salt ; 2-Mercaptoethanesulfonic acid sodium salt ; CCRIS 3712 ; Mesna ; Mesnex ; Mesnum ; Mistabron ; Mistabronco ; Mitexan ; Mucofluid ; Natrium 2-mercaptoethansulfonat ; Sodium 2-mercaptoethanesulfonate ; UNII-NR7O1405Q9 ; Uromitexan . Mesna (CAS NO.19767-45-4) is a white to off-white solid.