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CAS No.: | 199327-61-2 |
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Name: | 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one |
Article Data: | 25 |
Molecular Structure: | |
Formula: | C16H21N3O4 |
Molecular Weight: | 319.36 |
Synonyms: | 4(1H)-Quinazolinone,7-methoxy-6-[3-(4-morpholinyl)propoxy]- (9CI);4(3H)-Quinazolinone,7-methoxy-6-[3-(4-morpholinyl)propoxy]-; |
EINECS: | 429-400-7 |
Density: | 1.327 g/cm3 |
Melting Point: | 233-236 °C |
Boiling Point: | 519.53 °C at 760 mmHg |
Flash Point: | 268.002 °C |
PSA: | 76.68000 |
LogP: | 0.97070 |
4 (3-bromopropyl)-morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 65 - 70℃; for 5h; | 93.8% |
4-(3-chloropropyl)morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 55 - 60℃; for 5h; | 93.7% |
4-(3-iodopropyl)morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 75 - 80℃; for 5h; | 91.2% |
formamidine acetic acid
methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
In ethanol for 4h; Reflux; | 88% |
In methanol at 50 - 60℃; for 6h; | 81.73% |
In 2-methoxy-ethanol at 115℃; for 2h; | 78% |
In methanol at 50 - 60℃; for 6h; |
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
formaldehyd
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
In water at 130℃; for 48h; | 88% |
7-methoxy-6-(3'-N-morpholino)propoxyquinazoline
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline With ammonium cerium (IV) nitrate; acetic acid In water Stage #2: With sodium hydroxide In water | 87% |
With peracetic acid; sulfuric acid In ethanol at 60℃; for 12h; | 85% |
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
formic acid
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Heating; Stage #2: formic acid With hydrogenchloride In water at 90 - 130℃; Further stages.; | 86% |
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water at 80℃; for 3.5h; Stage #2: formic acid With hydrogenchloride In water at 130℃; for 4h; | 68.65% |
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Reflux; Stage #2: formic acid With hydrogenchloride In water at 130℃; for 3.5h; | 58% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With formamidine acetic acid | 82% |
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
formic acid
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid With formamide at 20 - 100℃; Stage #2: at 100℃; for 7h; | 78% |
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid In dichloromethane at 100℃; for 5h; Acidic conditions; Stage #2: With hydrogenchloride In water at 70℃; for 3h; Acidic aqueous solution; Stage #3: With sodium hydroxide In water at 20 - 25℃; Alkaline aqueous solution; | |
With formamide at 20℃; for 8h; Reflux; | 3.3 g |
ammonium formate
formamide
methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
at 170℃; for 3h; | 71.1% |
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Molecular structure of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one (CAS NO.199327-61-2) is:
Product Name: 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
Empirical Formula: C16H21N3O4
Molecular Weight: 319.3556
CAS Registry Number: 199327-61-2
Index of Refraction: 1.611
Molar Refractivity: 83.535 cm3
Molar Volume: 240.745 cm3
Surface Tension: 49.021 dyne/cm
Density: 1.327 g/cm3
Flash Point: 268.002 °C
Enthalpy of Vaporization: 79.231 kJ/mol
Boiling Point: 519.53 °C at 760 mmHg
Product Categories: Heterocycles; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one (CAS NO.199327-61-2) can be used as Gefitinib intermediate.
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one , its cas register number is 199327-61-2. It also can be called 7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(1H)-one ; 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one ; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone .