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CAS No.: | 2058-52-8 |
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Name: | CLOTHIAPINE |
Molecular Structure: | |
Formula: | C18H18 Cl N3 S |
Molecular Weight: | 343.88 |
Synonyms: | 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine;2-Chloro-11-(4-methylpiperazino)dibenzo[b,f][1,4]thiazepine; Clothiapin;Clothiapine; Clotiapine; Deliton; Entumine; Etumine; HF 2159; LW 2159 |
Density: | 1.33g/cm3 |
Melting Point: | 121-123℃ |
Boiling Point: | 483.8°Cat760mmHg |
Flash Point: | 246.4°C |
Safety: | Poison by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx. |
PSA: | 44.14000 |
LogP: | 3.44170 |
Empirical Formula: C18H18ClN3S
Molecular Weight: 343.8736 g/mol
EINECS: 218-162-8
Index of Refraction: 1.69
Density: 1.33 g/cm3
Flash Point: 246.4 °C
Enthalpy of Vaporization: 74.9 kJ/mol
Boiling Point: 483.8 °C at 760 mmHg
Vapour Pressure: 1.62E-09 mmHg at 25 °C
Structure of Clothiapine (CAS NO.2058-52-8):
IUPAC Name of Clothiapine (CAS NO.2058-52-8): 8-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzothiazepine
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 150mg/kg (150mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 657, 1969. | |
mouse | LD50 | intramuscular | 160mg/kg (160mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
mouse | LD50 | intravenous | 46mg/kg (46mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
mouse | LD50 | oral | 270mg/kg (270mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 841, 1965. | |
mouse | LD50 | subcutaneous | 348mg/kg (348mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
rat | LD50 | intramuscular | > 300mg/kg (300mg/kg) | Drugs in Japan Vol. 6, Pg. 233, 1982. | |
rat | LD50 | intravenous | 47mg/kg (47mg/kg) | Drugs in Japan Vol. -, Pg. 404, 1995. | |
rat | LD50 | oral | 280mg/kg (280mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
rat | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | Drugs in Japan Vol. 6, Pg. 233, 1982. |
Poison by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition Clothiapine (CAS NO.2058-52-8) emits very toxic fumes of Cl−, NOx, and SOx.
Clothiapine ,its cas register number is 2058-52-8. It also can be called Clotiapine ; Entumine ; and Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)- . It is an atypical antipsychotic of the dibenzothiazepine chemical class and is structurally analogous to quetiapine.