CAS No.2181-04-6,Potassium canrenoate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	2181-04-6
Name:	Potassium canrenoate

Formula:	C22H30 O4 . K
Molecular Weight:	396.568
Synonyms:	17a-Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, monopotassium salt (8CI); 17a-Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, potassium salt (7CI); Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, monopotassium salt, (17a)- (9CI); 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylicacid potassium salt; Aldadiene Kalium; Aldadiene potassium; Aldadiene potassiumsalt; CB 8109; Canrenoate potassium; Kanrenol; MF 465 a; Potassium17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylate; Potassium 3-(17b-hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate;Potassium 3-(3-oxo-17b-hydroxy-4,6-androstadien-17a-yl)propionate; Potassium aldadiene; Potassium canrenoate; Potassium b-(3-oxo-17b-hydroxyandrosta-4,6-dien-17a-yl)propionate; SC 14266; SC14266/371; Soldactona; Soldactone; Soludactone; Venactone
EINECS:	218-554-9
Density:	g/cm³
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Solubility:	Very soluble in water; soluble in alcohol; insoluble in coloroform and
Appearance:	Light yellow to tan powder
Hazard Symbols:
Risk Codes:	R22
Safety:	Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. A steroid. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes of K₂O.
PSA:	77.43000
LogP:	2.55550

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Chemistry

Product Name: Potassium 3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate
Synonyms: Aldadiene-potassium ; Canrenoate Potassium ;Canrenone free acid potassium salt ; Potassium 17-hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylate ; Potassium 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylate ; Potassium 3-(17-beta-hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate ; Potassium 3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate (non-preferred name)
Molecular Structure :
Molecular Formula : C₂₂H₂₉KO₄
Molecular Weight : 396.56
CAS NO: 2181-04-6
EINECS: 218-554-9
Appearance: Potassium canrenoate (CAS NO.2181-04-6) is color light yellow to tan powder.

Uses

Potassium canrenoate (CAS NO.2181-04-6) is for the metabolites of spironolactone Canrenoate acid potassium salt, role similar to spironolactone, but a lesser role in the feminization of male breast, it can be used as alternative medicine, mainly for heart failure, edema, and cirrhosis with ascites.

Toxicity Data With Reference

1.	mic-mus:lym 150 mg/L	ARTODN Archives of Toxicology. 61 (1988),201.
2.	orl-rat LD50:650 mg/kg	NICHAS Nichidai Igaku Zasshi. 36 (1977),7.
3.	ipr-rat LD50:183 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
4.	scu-rat LD50:160 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
5.	ivn-rat LD50:112 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
6.	orl-mus LD50:740 mg/kg	NICHAS Nichidai Igaku Zasshi. 36 (1977),7.
7.	ipr-mus LD50:140 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 149 (1964),8.
8.	scu-mus LD50:165 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.
9.	ivn-mus LD50:125 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 11 (1980),811.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. A steroid. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes of K₂O.
Hazard Codes Harmful Xn
Risk Statements 22
R22: Potassium canrenoate (CAS NO.2181-04-6) is harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS TU3500000