CAS No.22059-60-5,Disopyramid phosphate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	22059-60-5
Name:	Disopyramid phosphate

Formula:	C₂₁H₂₉N₃O^.H₃O₄P
Molecular Weight:	437.476
Synonyms:	SC 13957;2-Pyridineacetamide,R-[2-[bis(1-methylethyl)- amino]ethyl]-R-phenyl-,phosphate (1:1);Disopyramide phosphate (JAN/USP);Disopyramide phosphate;Rythmodan;Norpace (TN);4-(dipropan-2-ylamino)-2-phenyl-2-pyridin-2-yl-butanamide; phosphoric acid;
EINECS:	244-756-1
Boiling Point:	505.2 °C at 760 mmHg
Flash Point:	259.4 °C
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	36
PSA:	146.79000
LogP:	3.13360

Synthetic route

: 22059-60-5
disopyramide phosphate

: 74427-45-5, 74464-83-8, 74464-84-9, 3737-09-5
disopyramide

Conditions

Conditions	Yield
Stage #1: disopyramide phosphate With sodium hydroxide In n-heptane; water; toluene at 23 - 27℃; for 0.833333h; pH=12.65; Stage #2: at 20 - 46℃; for 4h; Stage #3: at 60℃; under 22.5023 Torr; for 7h; Purification / work up;	93.7%

: 22059-60-5
disopyramide phosphate

: 4-diisopropylamino-2-(4-iodo-phenyl)-2-pyridin-2-yl-butyramide

Conditions

Conditions	Yield
With Iodine monochloride In acetic acid at 20 - 45℃; for 1.5h; Iodination;	40%

: 14680-77-4
potassium tetrakis(4-chlorophenyl)borate

: 22059-60-5
disopyramide phosphate

: disopyramide tetrakis-(4-chlorophenyl)borate

Conditions

Conditions	Yield
In ethanol; water ion-pair complex formation;

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Chemistry

MF: C₂₁H₃₂N₃O₅P
MW: 437.47
EINECS: 244-756-1
Flash Point: 259.4 °C
Enthalpy of Vaporization: 77.49 kJ/mol
Boiling Point: 505.2 °C at 760 mmHg
Vapour Pressure: 2.48E-10 mmHg at 25°C
IUPAC Name: 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide ; phosphoric acid
Synonyms: Disopyramide phosphate ; Disopyramide phosphate salt ; Disopyramid phosphate ; 2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridinium phosphate ; Alpha-diisopropylaminoethyl-alpha-phenylpyridine-2-acet-amide phosphate salt ; Rythmodan ; Norpace cr ; Alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamid
Following is the molecular structure of Rythmodan (22059-60-5):

Uses

Rythmodan (22059-60-5) belongs to a group ofmedications called antiarrhythmics.This means it acts to correct irregular heartbeats to a normal rhythm and to slow an overactive heart. This allows the heart to work more efficiently.Rythmodan is used to treat and prevent ventricular arrhythmias (irregular heartbeat).Ask your doctor if you have any questions about why Rythmodan has been prescribed for you.

Toxicity Data With Reference

1.	ipr-rat TDLo:1820 mg/kg (male 10W pre):TER	JZKEDZ Jitchuken, Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Preclinical Reports. 7 (1981),145.
2.	orl-wmn LDLo:60 mg/kg/10D-I:SYS	NYSJAM New York State Journal of Medicine. 83 (1983),1057.
3.	orl-man TDLo:43 mg/kg/5D-I:SYS	NYSJAM New York State Journal of Medicine. 83 (1983),1057.
4.	orl-wmn TDLo:8 mg/kg/1D-I:LIV,BLD	SMJOAV Southern Medical Journal. 75 (1982),496.
5.	orl-man TDLo:1429 µg/kg:SYS	NNGAAS Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine. 72 (1983),1177.
6.	orl-chd LDLo:30 mg/kg	MJAUAJ Medical Journal of Australia. 2 (1978),335.
7.	orl-man TDLo:45 mg/kg/1W-I	SMJOAV Southern Medical Journal. 76 (1983),1453.
8.	orl-wmn TDLo:20 mg/kg/3D-I:CVS,BLD	AHJOA2 American Heart Journal. 105 (1983),870.
9.	orl-rat LD50:880 mg/kg	YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. 9 (Suppl 1)(1981),5.
10.	ipr-rat LD50:255 mg/kg	YACHDS

Safety Profile

Human poison by ingestion. Experimental poison by intravenous and intraperitoneal routes. Moderately toxic experimentally by ingestion and subcutaneous routes. Human systemic effects: arrhythmias, blood clotting factor change, hypoglycemia, liver function tests impaired, pulse rate increase, thrombocytopenia. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and PO_x.
Safety Information Rythmodan (22059-60-5):
Hazard Codes: Xn
Xn: Harmful
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: UR8440000