CAS No.22118-09-8,Bromoacetyl chloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	22118-09-8
Name:	Bromoacetyl chloride
Article Data:	41

Formula:	C₂H₂BrClO
Molecular Weight:	157.394
Synonyms:	2-Bromoacetylchloride;NSC 97376;
EINECS:	244-790-7
Density:	1.891 g/cm³
Boiling Point:	126.999 °C at 760 mmHg
Flash Point:	26.15 °C
Solubility:	Soluble in benzene, ether, chloroform
Appearance:	Colorless transparent or light yellow liquid
Hazard Symbols:	C
Risk Codes:	14-34-37
Safety:	26-36/37/39-45
Transport Information:	UN 3265 8/PG 2
PSA:	17.07000
LogP:	1.14670

Synthetic route

: 79-08-3
bromoacetic acid

: 22118-09-8
2-bromoacetyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 2h; Reflux; Inert atmosphere;	95.23%
With thionyl chloride at 80℃; for 6h;	95%
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Cooling with ice;	86.1%

: 17759-85-2
1,1-bromochloroethylene

A: 22118-09-8
2-bromoacetyl chloride

B: 15018-06-1
chloroacetyl bromide

Conditions

Conditions	Yield
Oxydation;

: 98-88-4
benzoyl chloride

: 79-08-3
bromoacetic acid

: 22118-09-8
2-bromoacetyl chloride

: 13094-51-4
bromoacetic anhydride

: 368-44-5
dichloro(fluoro)(phenyl)silane

A: 22118-09-8
2-bromoacetyl chloride

B: 1344680-40-5
PhSiFClOC(O)CH2Br

Conditions

Conditions	Yield
at 20℃;

...Expand

: 493-08-3
chromane

: 22118-09-8
2-bromoacetyl chloride

: 151427-16-6
6-(bromoacetyl)chroman

Conditions

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane for 1h; below 5 deg C;	100%
With aluminum (III) chloride In dichloromethane at 0℃; for 0.5h; Inert atmosphere;	34%

: 22118-09-8
2-bromoacetyl chloride

: 24043-40-1
diethyl 2-[(4-methoxyphenyl)amino]malonate

: 106817-55-4
diethyl 2-(2-bromo-N-(4-methoxyphenyl)acetamido)malonate

Conditions

Conditions	Yield
In benzene for 2h; Heating;	100%

: 22118-09-8
2-bromoacetyl chloride

: 150650-99-0
1-(N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

: 1-(N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl)-2-bromoacetyl hydrazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate for 0.5h; Ambient temperature;	100%

: 22118-09-8
2-bromoacetyl chloride

: 150651-04-0
1-(N-tert-butyloxycarbonyl-L-valyl-Nε-tosyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

: 1-(N-tert-butyloxycarbonyl-L-valyl-Nε-tosyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl)-2-bromoacetyl hydrazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate for 0.5h; Ambient temperature;	100%

: 22118-09-8
2-bromoacetyl chloride

: 50399-51-4, 215371-20-3
trans-1,2,3,4-tetrahydro-7-methoxy-1-naphthylamine

: N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)bromoacetamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane	100%

: 22118-09-8
2-bromoacetyl chloride

: 53793-13-8
2,3-dimethyl-5-imino-Δ2-1,3,4-thiadiazoline

: 2-bromo-N-(3,5-dimethyl-3H-[1,3,4]thiadiazol-2-ylidene)-acetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	100%

Raw Materials

368-44-5

79-08-3

98-88-4

Downstream Products

Total:69 Page 1 of 2 1 2 Next>>

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Specification

The Bromoacetyl chloride, with the CAS registry number 22118-09-8, is also known as 2-Bromoacetylchloride. It belongs to the product categories of Acid Halides; Carbonyl Compounds; Organic Building Blocks. Its EINECS number is 244-790-7. This chemical's molecular formula is C₂H₂BrClO and molecular weight is 157.39. What's more, its systematic name is Bromoacetyl chloride. This chemical is used as raw material to prepare ω-Bromo-2,4-dichloroacetophenone. It is also a kind of intermediate to prepare imazalil and propiconazole.

Physical properties of Bromoacetyl chloride are: (1)ACD/LogP: 1.154; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.15; (4)ACD/LogD (pH 7.4): 1.15; (5)ACD/BCF (pH 5.5): 4.44; (6)ACD/BCF (pH 7.4): 4.44; (7)ACD/KOC (pH 5.5): 101.17; (8)ACD/KOC (pH 7.4): 101.17; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.486; (14)Molar Refractivity: 23.925 cm³; (15)Molar Volume: 83.235 cm³; (16)Polarizability: 9.485×10^-24cm³; (17)Surface Tension: 38.5 dyne/cm; (18)Density: 1.891 g/cm³; (19)Flash Point: 26.15 °C; (20)Enthalpy of Vaporization: 36.479 kJ/mol; (21)Boiling Point: 126.999 °C at 760 mmHg; (22)Vapour Pressure: 11.4 mmHg at 25°C.

Uses of Bromoacetyl chloride: it can be used to produce 1-bromoacetyl-pyrrolidine at the temperature of 0 °C. It will need regent Et₃N and solvent CH₂Cl₂ with the reaction time of 2 hours. The yield is about 60%.

Bromoacetyl chloride can be used to produce 1-bromoacetyl-pyrrolidine at the temperature of 0 °C

When you are using this chemical, please be cautious about it as the following:
This chemical can react violently with water. It can cause burns and is irritating to respiratory system. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, you need to seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: BrCC(Cl)=O
(2)Std. InChI: InChI=1S/C2H2BrClO/c3-1-2(4)5/h1H2
(3)Std. InChIKey: SYZRZLUNWVNNNV-UHFFFAOYSA-N