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CAS No.: | 22199-08-2 |
---|---|
Name: | Silver sulfadiazine |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C10H9AgN4O2S |
Molecular Weight: | 357.141 |
Synonyms: | Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-NN,O1)-;Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt (8CI);Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex;Dermazin;Flamazine;Flammazine;Geben;NSC 625324;Silvadene;Silver 2-sulfanilamidopyrimidine;Silverol;Sulfadiazine silver; |
EINECS: | 244-834-5 |
Density: | 1.496g/cm3 |
Melting Point: | 285 °C (dec.)(lit.) |
Boiling Point: | 512.6 °C at 760 mmHg |
Flash Point: | 263.8 °C |
Appearance: | solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 94.32000 |
LogP: | 3.11490 |
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The Sulfadiazine silver salt is an organic compound with the formula C10H9AgN4O2S. The IUPAC name of this chemical is silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide. With the CAS registry number 22199-08-2, it is also named as Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt. The product's categories are Ag (Silver) Compounds;Antibiotics for Research and Experimental Use; Biochemistry; Classes of Metal Compounds; Sulfonamides (Antibiotics for Research and Experimental Use); Transition Metal Compounds; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. Besides, it is a topical sulfonamide/silver antibacterial used as a topical burn cream on burns, including chemical burns. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin.
Physical properties about Sulfadiazine silver salt are: (1)ACD/LogP: -0.12; (2)#H bond acceptors: 6; (3)#H bond donors: 3; (4)#Freely Rotating Bonds: 2; (5)Polar Surface Area: 83.57 Å2; (6)Flash Point: 263.8 °C; (7)Enthalpy of Vaporization: 78.38 kJ/mol; (8)Boiling Point: 512.6 °C at 760 mmHg; (9)Vapour Pressure: 1.28E-10 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: [Ag+].O=S(=O)([N-]c1ncccn1)c2ccc(N)cc2
(2)InChI: InChI=1/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
(3)InChIKey: UEJSSZHHYBHCEL-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
(5)Std. InChIKey: UEJSSZHHYBHCEL-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | skin | 536mg/kg/21W- (536mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Lancet. Vol. 340, Pg. 126, 1992. |
mouse | LDLo | intraperitoneal | 550mg/kg (550mg/kg) | United States Patent Document. Vol. #4020150, | |
mouse | LDLo | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
mouse | LDLo | subcutaneous | > 10gm/kg (10000mg/kg) | LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
rat | LD50 | intraperitoneal | 126mg/kg (126mg/kg) | LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982. | |
rat | LD50 | unreported | 160mg/kg (160mg/kg) | United States Patent Document. Vol. #4535078, | |
rat | LDLo | subcutaneous | > 10gm/kg (10000mg/kg) | LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |