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| CAS No.: | 2231-57-4 |
|---|---|
| Name: | Thiocarbohydrazide |
| Article Data: | 61 |
| Molecular Structure: | |
|
|
|
| Formula: | CH6N4S |
| Molecular Weight: | 106.151 |
| Synonyms: | Carbohydrazide,thio- (6CI,7CI,8CI);1,3-Diamino-2-thiourea;Hydrazinecarbohydrazonothioicacid;NSC 689;TCH;Thiocarbazide;Carbonothioicdihydrazide;Thiocarbonicdihydrazide;Thiocarbonohydrazide; |
| EINECS: | 218-769-8 |
| Density: | 1.415 g/cm3 |
| Melting Point: | 171-174 °C (dec.)(lit.) |
| Boiling Point: | 230.1 °C at 760 mmHg |
| Flash Point: | 93 °C |
| Appearance: | white to grey-beige crystalline powder |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 5-26/28-36/38-21 |
| Safety: | 28-36/37/39-45-38-36/37-28A-1 |
| Transport Information: | UN 2811 6.1/PG 1 |
| PSA: | 108.19000 |
| LogP: | 0.38030 |
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| Conditions | Yield |
|---|---|
| With hydrazine In water at 20℃; for 0.333333h; Green chemistry; | 98% |
| With hydrazine hydrate | 89% |
| With hydrazine hydrate In water at 90℃; for 1h; | 83.7% |
| Conditions | Yield |
|---|---|
| In water at 20℃; for 0.166667h; Green chemistry; | 98% |
- 16022-57-4
ethyl piperidine-1-carbodithioate
A
- 21198-50-5
piperidine-1-carbothioic acid hydrazide
B
- 2231-57-4
Thiocarbohydrazide
| Conditions | Yield |
|---|---|
| With ethanol; hydrazine hydrate |
- 16022-57-4
ethyl piperidine-1-carbodithioate
- 2231-57-4
Thiocarbohydrazide
| Conditions | Yield |
|---|---|
| With ethanol; hydrazine hydrate |
| Conditions | Yield |
|---|---|
| With diethyl ether; hydrazine hydrate | |
| With hydrazine hydrate |
| Conditions | Yield |
|---|---|
| With ethanol; hydrazine hydrate |
| Conditions | Yield |
|---|---|
| With ethanol; hydrazine hydrate |
- 37527-08-5
O-tert-butyl S-methyl carbonodithioate
- 2231-57-4
Thiocarbohydrazide
| Conditions | Yield |
|---|---|
| With hydrazine |
- 2231-57-4
Thiocarbohydrazide
| Conditions | Yield |
|---|---|
| With hydrazine hydrate Yield given; |
- 2231-57-4
Thiocarbohydrazide
| Conditions | Yield |
|---|---|
| With water; lead(II) oxide |
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Chemistry
IUPAC Name:1,3-Diaminothiourea (2231-57-4)
Synonyms: Aurora 1561 ; Carbonothioic dihydrazide ; Tch ; Thiocarbonohydrazide ; Thiocarbonyldihydrazide ;Tthiocarbazide ;Thiocarbohydrazide ;Thiocarbohydrazide, for electron microsc opy .
CAS: 2231-57-4
MF: CH6N4S
MW: 106.15
EINECS: 218-769-8
MS: 
Mol File: 2231-57-4.mol
Surface Tension: 92.2 dyne/cm
Density: 1.415 g/cm3
Flash Point: 93 °C
Melting point: 171-174 °C (dec.)(lit.)
Enthalpy of Vaporization: 46.67 kJ/mol
Boiling Point: 230.1 °C at 760 mmHg
Vapour Pressure: 0.067 mmHg at 25°C
Storage temp: Poison room
Sensitive: Light Sensitive
BRN : 506657
Uses
Thiocarbohydrazide (2231-57-4) is widely used in organic synthesis and important raw materials of Metribuzin of highly efficient broad-spectrum herbicide .
Production
Preparation method of Thiocarbohydrazide (2231-57-4):add carbon disulfide into the reactor,then with cooling and stirring, add hydrazine hydrate dropwisly, and then warming up to remove off hydrogen sulfide gas. hydrogen sulfide with absorption of alkali to form sodium sulfide, after cooling of reaction solution then derive crystallization.by the way of filtration, washing, filtrate can be used as mother liquor cycle to apply. Then get Thiocarbohydrazide (2231-57-4) by washing the filter cake.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| guinea pig | LD50 | oral | 8200ug/kg (8.2mg/kg) | behavioral: somnolence (general depressed activity) | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994. |
| mouse | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | | National Technical Information Service. Vol. AD277-689, |
| mouse | LD50 | oral | 6mg/kg (6mg/kg) | behavioral: somnolence (general depressed activity) | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994. |
| rat | LC50 | inhalation | 50mg/m3/4H (50mg/m3) | peripheral nerve and sensation: fasciculations | National Technical Information Service. Vol. OTS0555465, |
| rat | LD50 | oral | 21600ug/kg (21.6mg/kg) | behavioral: somnolence (general depressed activity) | Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (2), Pg. 43, 1994. |
| rat | LD50 | skin | > 500mg/kg (500mg/kg) | behavioral: somnolence (general depressed activity) | National Technical Information Service. Vol. OTS0555465, |
Safety Profile
Hazard Codes: T+ .gif){kind=small}
Risk Statements : 5-21-26/28-36/38
5: Heating may cause an explosion
21: Harmful in contact with skin
26/28: Very Toxic by inhalation and if swallowed
36/38: Irritating to eyes and skin
Safety Statements: 36/37/39-45-38-28A-1
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
38: In case of insufficient ventilation, wear suitable respiratory equipment
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
1: Keep locked up
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS : FF2975000
F: 4.4-8
HazardClass: 6.1
PackingGroup: I
Specification
1.Chemical Properties:Thiocarbohydrazide (2231-57-4) is white to grey-beige crystalline powder
2.General Description: Crystalline needles and plates. Used in electron microscopy to produce electron-opaque deposits for ultra structural analysis.
3.Reactivity Profile :Thiocarbohydrazide is a thioamide, which may behave as a weak base and therefore will react with acids forming salts with production of heat. Thiocarbohydrazide may react with acids and reducing agents to form toxic hydrogen sulfide gas. This may be vigorous depending on the nature of the reducing agent. Organic amides/imides react with azo and diazo compounds to generate toxic gases. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
4.Health Hazard :High oral toxicity.
5.Fire Hazard: When heated to decomposition Thiocarbohydrazide emits very toxic fumes of nitrogen oxides and sulfur oxides.