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CAS No.: | 224185-19-7 |
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Name: | 4-Bromo-5-fluoro-2-nitrotoluene |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C7H5BrFNO2 |
Molecular Weight: | 234.025 |
Synonyms: | 1-Bromo-2-fluoro-4-methyl-5-nitrobenzene; |
EINECS: | 218-838-2 |
Density: | 1.696 g/cm3 |
Melting Point: | 59-63 °C |
Boiling Point: | 266.6 °C at 760 mmHg |
Flash Point: | 115.1 °C |
Hazard Symbols: | Xn, Xi |
Risk Codes: | 22-36-36/37/38 |
Safety: | 26-36/37-36 |
PSA: | 45.82000 |
LogP: | 3.32800 |
4-bromo-3-fluorotoluene
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
With sulfuric acid; potassium nitrate at 0 - 20℃; | 100% |
With sulfuric acid; potassium nitrate at 0℃; | 100% |
With sulfuric acid; nitric acid at 0℃; | 92% |
2-fluoro-4-methyl-5-nitro-phenylamine
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-4-methyl-5-nitro-phenylamine With hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 0.25h; Stage #2: With copper(I) oxide; hydrogen bromide In water at 0℃; | 91% |
3-fluoro-6-nitrotoluene
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
With sulfuric acid; bromine; silver nitrate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate | 83% |
copper(I) bromide
2-fluoro-4-methyl-5-nitro-phenylamine
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
With sodium nitrite In water; hydrogen bromide | 50% |
sodium ethanolate
3-bromo-4-fluoro-6-methylnitrobenzene
1-bromo-2-ethoxy-4-methyl-5-nitrobenzene
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol at 20℃; for 1h; | 99% |
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Microwave irradiation; | 99% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Inert atmosphere; Microwave irradiation; | 99% |
2,4-difluorophenol
3-bromo-4-fluoro-6-methylnitrobenzene
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; | 99% |
With caesium carbonate In dimethyl sulfoxide at 100℃; for 3h; | 3.8 g |
3-bromo-4-fluoro-6-methylnitrobenzene
5-bromo-4-fluoro-2-methylaniline
Conditions | Yield |
---|---|
With 2,3-dimethyl-2,3-butane diol; [MoO2Cl2(dmf)2] In o-xylene at 130℃; for 3h; chemoselective reaction; | 95% |
With iron; ammonium chloride In water for 48.5h; Heating / reflux; | 72% |
With ammonium chloride; iron In water for 48h; Heating / reflux; | 72% |
bis(pinacol)diborane
3-bromo-4-fluoro-6-methylnitrobenzene
2-(2-fluoro-4-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; potassium acetate In 1,4-dioxane at 100℃; for 1h; Suzuki Coupling; Inert atmosphere; Sealed tube; | 91% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 90℃; for 15h; Inert atmosphere; |
methanol
3-bromo-4-fluoro-6-methylnitrobenzene
1-bromo-2-methoxy-4-methyl-5-nitrobenzene
Conditions | Yield |
---|---|
Stage #1: methanol With sodium at 0℃; for 0.5h; Stage #2: 3-bromo-4-fluoro-6-methylnitrobenzene at 30℃; for 2h; | 87.8% |
With sodium at 40℃; for 2h; Cooling with ice; |
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4-Bromo-5-Fluoro-2-Nitrotoluene(224185-19-7) is also named as 2-Nitro-4-Bromo-5-Fluorotoluene;1-Bromo-2-fluoro-4-methyl-5-nitro-benzene,and so on.
CAS: 224185-19-7
Molecular Formula: C7H5BrFNO2
Molecular Weight: 234.02
Molecular structure:
Melting point: 59-63°C
Index of Refraction: 1.57
Molar Refractivity: 45.3 cm3
Molar Volume: 137.9 cm3
Polarizability: 17.96 10-24cm3
Surface Tension: 45.3 dyne/cm
Density: 1.696 g/cm3
Flash Point: 115.1 °C
Enthalpy of Vaporization: 48.43 kJ/mol
Boiling Point: 266.6 °C at 760 mmHg
Vapour Pressure: 0.0141 mmHg at 25°C