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Basic Information
| CAS No.: | 23056-39-5 |
|---|---|
| Name: | 2-Chloro-4-methyl-3-nitropyridine |
| Article Data: | 15 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5ClN2O2 |
| Molecular Weight: | 172.571 |
| Synonyms: | 4-Picoline,2-chloro-3-nitro- (6CI,8CI);2-Chloro-3-nitro-4-methylpyridine;NSC 402977; |
| Density: | 1.406 g/cm3 |
| Melting Point: | 51-53 °C(lit.) |
| Boiling Point: | 279.6 °C at 760 mmHg |
| Flash Point: | 122.9 °C |
| Appearance: | Off-white to light yellow crystal |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | 36/37/38-21/22 |
| Safety: | 26-37/39-36/37/39-36 |
| Transport Information: | UN 2811 |
| PSA: | 58.71000 |
| LogP: | 2.47480 |
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2-Chloro-4-methyl-3-nitropyridine
Chemistry
2-Chloro-4-methyl-3-nitropyridine(23056-39-5) exists as off-white to light yellow crystal.
Molecular Structure:
Molecular Formula:C6H5ClN2O2
Molecular Weight:172.57
Density:1.406 g/cm3
Melting Point:51-53 ℃
Boiling Point:279.6 ℃ at 760 mmHg
Flash Point:113 ℃
Molecular Structure:
Molecular Formula:C6H5ClN2O2
Molecular Weight:172.57
Density:1.406 g/cm3
Melting Point:51-53 ℃
Boiling Point:279.6 ℃ at 760 mmHg
Flash Point:113 ℃
Uses
2-Chloro-4-methyl-3-nitropyridine(23056-39-5) is used as intermediates in organic synthesis. 2-Chloro-4-methyl-3-nitropyridine(23056-39-5) is an important raw material for fine chemistry industry.
Production
The diazonium salt from 2-AMINO-4-METHYLPYRIDINE is converted to 2-hydroxy-4-methylpyridine, which is nitrated to give 2-hydroxy-4-methyl-3-nitropyridine. Conversion to 2-chloro-4-methyl-3-nitropyridine is effected with phosphorous oxychloride and phosphorous pentachloride. Reduction of 2-chloro-4-methyl-3-nitropyridine with HYDROGEN/Raney NICKEL provides 3-amino-2-chloro-4-methylpyridine, which is condensed with 2-chloronicotinoyl chloride to give 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide . Treatment with cyclopropylamine affords N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide, which is cyclized in the presence of Sodium hydride to yield Nevirapine.
Safety Profile
Hazard Codes: 
Xi,Xn
Risk Statements: 36/37/38-21/22
36/37/38: Irritating to eyes, respiratory system and skin
21/22: Harmful in contact with skin and if swallowed
Safety Statements: 26-37/39-36/37/39-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
36: Wear suitable protective clothing
RIDADR: UN2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
Xi,Xn Risk Statements: 36/37/38-21/22
36/37/38: Irritating to eyes, respiratory system and skin
21/22: Harmful in contact with skin and if swallowed
Safety Statements: 26-37/39-36/37/39-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
36: Wear suitable protective clothing
RIDADR: UN2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III