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| CAS No.: | 23288-49-5 |
|---|---|
| Name: | Probucol |
| Article Data: | 14 |
| Molecular Structure: | |
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| Formula: | C31H48O2S2 |
| Molecular Weight: | 516.853 |
| Synonyms: | Acetone,bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole (8CI);Phenol, 4,4'-(isopropylidenedithio)bis[2,6-di-tert-butyl-(8CI);4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol];Biphenabid;Bisbid;Bisphenabid;DH 581;Lipomal;Lorelco;Lurselle;NSC 652160;NSC 86225;Panavir;Phenbutol;Probucol;Sinlestal; |
| EINECS: | 245-560-9 |
| Density: | 1.07 g/cm3 |
| Melting Point: | 126-128 °C |
| Boiling Point: | 546.7 °C at 760 mmHg |
| Flash Point: | 264.9 °C |
| Appearance: | White Solid |
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- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
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Chemistry
Probucol(23288-49-5) is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease.
However, clinical trials were stopped after it was found that it causes long QT syndrome in patients.
Probucol(23288-49-5) was initially developed in the 1970s by a chemical company to maximize airplane tire longevity.
The molecular formula of Probucol is C31H48O2S2 and its formula weight is 516.84.
The density of Probucol(23288-49-5) is 1.07 g/cm3 . The boiling point is 546.7 °C at 760 mmHg. The refractive index is about 1.573. Its flash point is 264.9 °C.
The chemical synonyms of Probucol(23288-49-5) are PROBUCOL;4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno;biphenabid;bisbid;bisphenabid;dh581;4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL;4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol
The molecular structure of Probucol(23288-49-5):
Uses
Standards and Recommendations
Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.
It is believed to act at ABCA1.
It also lowers levels of HDL.
Specification
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Sulfur oxides.