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| CAS No.: | 23541-50-6 |
|---|---|
| Name: | Daunorubicin hydrochloride |
| Article Data: | 6 |
| Molecular Structure: | |
|
|
|
| Formula: | C27H29NO10.HCl |
| Molecular Weight: | 563.989 |
| Synonyms: | 5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,hydrochloride, (8S,10S)- (9CI);Cerubidine;Daunoblastin;Daunomycin chlorohydrate;NDC0082-4155;Ondena;RP 13057 hydrochloride;Rubidomycin hydrochloride; |
| EINECS: | 245-723-4 |
| Density: | 1.554 g/cm3 |
| Melting Point: | 190°C (dec) |
| Boiling Point: | 770 °C at 760 mmHg |
| Flash Point: | 419.5 °C |
| Appearance: | dark red crystals |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-40-42/43-36/37/38-20/21/22 |
| Safety: | 22-36/37-45-37/39-36-26 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 185.84000 |
| LogP: | 2.53120 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 240444-70-62,3,5,6-Tetrafluor-4-(methoxymethyl)benzyl-2,2-dimethyl-3-(prop-1-en-1-yl)cyclopropancarboxylat
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 36508-71-1
Benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 23541-50-6
daunomycin hydrochloride
B
- 613-94-5
benzoic acid hydrazide
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
- 110925-43-4
Nicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 553-53-7
Nicotinic acid hydrazide
B
- 23541-50-6
daunomycin hydrochloride
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer; |
- 110925-39-8
Isonicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 54-85-3
isoniazid
B
- 23541-50-6
daunomycin hydrochloride
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer; |
- 110925-32-1
4-Amino-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 23541-50-6
daunomycin hydrochloride
B
- 5351-17-7
4-aminobenzohydrazide
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
- 66996-57-4
4-Hydroxy-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 23541-50-6
daunomycin hydrochloride
B
- 5351-23-5
4-hydroxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
- 110925-36-5
3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride
A
- 23541-50-6
daunomycin hydrochloride
B
- 110925-44-5
ethyl m-hydrazinecarbonyl benzoate
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
- 110925-37-6
4-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride
A
- 19827-16-8
4-hydrazinocarbonyl-benzoic acid ethyl ester
B
- 23541-50-6
daunomycin hydrochloride
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
- 193743-47-4
daunoform
- 23541-50-6
daunomycin hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: daunoform In dimethylsulfoxide-d6; water-d2 for 24h; Stage #2: With hydrogenchloride In dimethylsulfoxide-d6; water-d2 |
- 23541-50-6
daunomycin hydrochloride
- 407-25-0
trifluoroacetic anhydride
- 219921-59-2
3'-N,4'-O-di-trifluoroacetyldaunomycin
| Conditions | Yield |
|---|---|
| In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere; | 100% |
| In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere; | 100% |
| In dichloromethane at 0℃; for 1.5h; |
- 23541-50-6
daunomycin hydrochloride
| Conditions | Yield |
|---|---|
| In aq. acetate buffer at 20℃; for 24h; pH=5.2; | 100% |
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Chemistry
MW: 563.98
EINECS: 245-723-4
mp： 190°C (dec)
storage temp： 20°C
form: solid
Merck: 13,2852
Synonyms:WP900 HYDROCHLORIDE;daunoblastin;daunoblastina; daunomycinchlorohydrate; ndc00824155;ondena;rp13057hydrochloride; rubidomycinhydrochloride
The structure of Daunorubicin hydrochloride(23541-50-6) is:
Uses
Toxicity Data With Reference
| 1. | mmo-sat 83 ng/plate | CNREA8 Cancer Research. 38 (1978),2148. | ||
| 2. | mmo-asn 250 mg/L | MUREAV Mutation Research. 97 (1982),293. | ||
| 3. | orl-rat LD50:290 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437. | ||
| 4. | ipr-rat LD50:14,300 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437. | ||
| 5. | scu-rat LD50:33,200 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437. | ||
| 6. | ivn-rat LD50:14,300 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437. | ||
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Consensus Reports
Safety Profile
Hazard Codes: Xn,Xi
Risk Statements: 22-40-42/43-36/37/38-20/21/22
Safety Statements: 22-36/37-45-37/39-36-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HB7878000
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits very toxic fumes of NOx and HCl.