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| CAS No.: | 2392-39-4 |
|---|---|
| Name: | Dexamethasone 21-phosphate disodium salt |
| Molecular Structure: | |
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| Formula: | C22H30FO8P.2Na |
| Molecular Weight: | 516.45 |
| Synonyms: | Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16a)- (9CI);Dexagro;Dexamethasone 21-(disodium phosphate);Dexamethasone phosphate sodium salt;Dexamethazone sodium phosphate;Dezone;Disodium dexamethasone 21-phosphate; |
| EINECS: | 219-243-0 |
| Density: | 1.32g/cm3 |
| Melting Point: | 233-235 °C |
| Boiling Point: | 669.6 °C at 760 mmHg |
| Flash Point: | 358.7 °C |
| Solubility: | water: 50 mg/mL, clear, faintly yellow |
| Appearance: | White to off white powder |
| Hazard Symbols: | R22:; R40:; R63:; |
| Risk Codes: | 22-40-63 |
| Safety: | 36/37/39 |
| PSA: | 156.83000 |
| LogP: | 2.88910 |
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Consensus Reports
Specification
The Decadron phosphate, with the cas register number 2392-39-4, has the systematic name of disodium (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate. This is a kind of white to off-white powder. Besides, the product categories are various, including immunomodulators and antibioticslipids; steroids (c21) and derivatives; immune cell signaling and blood; immune system regulation; sterols. When store it, you should keep in at 2-8°C.
The characteristics of this chemical are as follows: (1)ACD/LogP: 0.65; (2)ACD/LogD (pH 5.5): -2.77; (3)ACD/LogD (pH 7.4): -3.69; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 8; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 129.17; (12)Flash Point: 358.7 °C; (13)Enthalpy of Vaporization: 112.61 kJ/mol; (14)Boiling Point: 669.6 °C at 760 mmHg; (15)Vapour Pressure: 8.62E-21 mmHg at 25°C.
As to its usage, it is widely applied in the pharmaceutics. It is usually used as the adrenal cortex hormonic drug, which has the function of being anti-flammatory, antitoxic, and antiallergic.
While dealing with this chemical, you should be very cautious. For being a kind of harmful chemical, it may cause damage to health, and if swallowed, it will be very dangerous. Besides, it has possible risk of harm to the unborn child, and even has limited evidence of a carcinogenic effect. Therefore, you should take the following instruction. Wear suitable protective clothing, gloves and eye/face protection. If you need more safety information, you could refer to WGK Germany 3.
In addition, you could obtain the molecular structure by converting the following datas:
(1)SMILES:[Na+].[Na+].[O-]P([O-])(=O)OCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3C)C)C
(2)InChI:InChI=1/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
Below are the toxicity information of this chemical:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 1mg/kg (1mg/kg) | GASTROINTESTINAL: PERITONITIS | American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992. |
| infant | TDLo | intravenous | 1500ug/kg/3D- (1.5mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS | Lancet. Vol. 1, Pg. 632, 1987. |
| man | TDLo | intravenous | 357ug/kg (0.357mg/kg) | GASTROINTESTINAL: PERITONITIS | American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992. |
| mouse | LD50 | intraperitoneal | 550mg/kg (550mg/kg) | Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984. | |
| mouse | LD50 | intravenous | 932mg/kg (932mg/kg) | Drugs in Japan Vol. -, Pg. 785, 1995. | |
| mouse | LD50 | oral | 1800mg/kg (1800mg/kg) | Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984. | |
| women | TDLo | intravenous | 320mg/kg (320mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Lancet. Vol. 1, Pg. 1035, 1986. |