CAS No.23986-74-5,germacreneD,1-methyl-5-methylene-8-(1-methylethyl)-1,6-cyclodecadiene Suppliers

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Basic Information

Molecular Structure:
CAS No.:	23986-74-5
Name:	germacreneD,1-methyl-5-methylene-8-(1-methylethyl)-1,6-cyclodecadiene
Article Data:	8

Formula:	C15H24
Molecular Weight:	204.356
Synonyms:	1,6-Cyclodecadiene,1-methyl-5-methylene-8-(1-methylethyl)-, [S-(E,E)]-; Germacra-1(10),4(15),5-triene,(-)- (8CI); (-)-Germacrene D; Germacrene D
Density:	0.85g/cm³
Boiling Point:	279.7°C at 760 mmHg
Flash Point:	111.9°C
PSA:	0.00000
LogP:	4.89130

Synthetic route

: 106-28-5
Farnesol

: 23986-74-5
germacrene D

Conditions

Conditions	Yield
With sodium carbonate; magnesium chloride In terpene synthase buffer at 25℃; for 18h; pH=10; Enzymatic reaction;	91.1%

: 106-28-5
Farnesol

A: 483-76-1, 13061-82-0, 16729-01-4, 20085-20-5, 60305-17-1, 73365-79-4
delta-cadinene

B: 23986-74-5
germacrene D

Conditions

Conditions	Yield
With sodium acetate; magnesium chloride In terpene synthase buffer at 25℃; for 18h; pH=5; Enzymatic reaction;	A 12.32% B 84.3%

: 106-28-5
Farnesol

A: β-cubebene

B: cubebol

C: 483-76-1, 13061-82-0, 16729-01-4, 20085-20-5, 60305-17-1, 73365-79-4
delta-cadinene

D: 23986-74-5
germacrene D

E: β-copaene

Conditions

Conditions	Yield
With potassium chloride In terpene synthase buffer at 25℃; for 18h; pH=8; Enzymatic reaction;	A 10.7% B 34.2% C 15% D 19.4% E 10.3%

...Expand

: 106-28-5
Farnesol

A: 3650-28-0, 6813-05-4, 16641-59-1, 22338-87-0, 29642-51-1, 149884-32-2
sativene

B: β-cubebene

C: cubebol

D: 483-76-1, 13061-82-0, 16729-01-4, 20085-20-5, 60305-17-1, 73365-79-4
delta-cadinene

E: 23986-74-5
germacrene D

F: β-copaene

Conditions

Conditions	Yield
With potassium chloride In terpene synthase buffer at 37℃; for 18h; pH=8; Enzymatic reaction;	A 5.3% B 7.1% C 22.3% D 13.3% E 22.3% F 12.3%

...Expand

: 372-97-4, 13058-04-3, 25744-33-6, 27248-37-9, 27248-38-0, 40716-68-5
farnesyl pyrophosphate

: 23986-74-5
germacrene D

Conditions

Conditions	Yield
With germacradienol synthase SC9B1.20; 2-hydroxyethanethiol In pentane at 30℃; for 24h;	1.6 mg
With (S)-germacrene D synthase; 3-[(3-cholamidopropyl)dimethylammonio]propanesulfonate; glycerol; 2-amino-2-hydroxymethyl-1,3-propanediol; 2-hydroxyethanethiol; magnesium chloride In chloroform-d1; water at 25℃; for 24h; pH=7.5; Enzymatic reaction;
With Y406F-GDS-His6 In pentane at 20℃; for 120h; pH=7.5; Kinetics; Enzymatic reaction;

: 118655-72-4
(2E,6E)-<1,1-2H2>-farnesyl diphosphate

A: C12H18(2)H2

B: C15H25(2)HO

C: C12H19(2)H3O

D: 23986-74-5
germacrene D

Conditions

Conditions	Yield
With Streptomyces coelicolor germacradienol synthase; Tris-Cl; magnesium chloride In water-d2 at 30℃; Enzymatic reaction;

...Expand

: 372-97-4, 13058-04-3, 25744-33-6, 27248-37-9, 27248-38-0, 40716-68-5
farnesyl pyrophosphate

A: (1S,4aS)-1,4a-Dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

B: 19700-21-1
(-)-geosmin

C: 23986-74-5
germacrene D

D: (–)-(4S,7R)-germacra-(1(10)E,5E)-dien-11-ol

Conditions

Conditions	Yield
With Streptomyces coelicolor germacradienol synthase; Tris-Cl; magnesium chloride In water at 30℃; for 4h; Enzymatic reaction;

...Expand

: 372-97-4, 13058-04-3, 25744-33-6, 27248-37-9, 27248-38-0, 40716-68-5
farnesyl pyrophosphate

A: 207221-31-6
4α-hydroxygermacra-1(10),5-diene

B: 25246-27-9
alloaromadendrene

C: 23986-74-5
germacrene D

D: 41437-00-7, 67650-49-1, 67650-90-2, 79951-53-4, 100762-45-6, 100762-46-7, 100762-48-9, 100762-49-0, 133005-43-3, 24703-35-3
(+)-bicyclogermacrene

Conditions

Conditions	Yield
With recombinant (His)8-tagged Medicago truncatula MtTPS5 sesquiterpene synthase Y526F mutant; water; magnesium chloride In pentane at 30℃; for 1.5h; pH=7.5; Mechanism; aq. buffer; Enzymatic reaction; optical yield given as %ee; stereospecific reaction;

...Expand

: 372-97-4, 13058-04-3, 25744-33-6, 27248-37-9, 27248-38-0, 40716-68-5
farnesyl pyrophosphate

A: 19435-97-3
δ-cadinol

B: (+)-copan-3-ol

C: 23986-74-5
germacrene D

D: 23445-02-5
(-)-(1R,4S,5R,6R,7S,10R)-7-isopropyl-4,10-dimethyl-tricyclo[4.4.0.01,5]decane-4-ol

Conditions

Conditions	Yield
With recombinant (His)8-tagged Medicago truncatula MtTPS5 sesquiterpene synthase; water; magnesium chloride In pentane at 30℃; for 1.5h; pH=7.5; Mechanism; aq. buffer; Enzymatic reaction; optical yield given as %ee; stereospecific reaction;

...Expand

: 556-82-1
3-methyl-2-buten-1-ol

: 23986-74-5
germacrene D

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Escherichia coli hydroxyethylthiazole kinase; ATP; pyruvate kinase / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction 2: isopentenyl phosphate kinase from Methanocaldococcus jannaschii; ATP; pyruvate kinase / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction 3: (2E,6E)-FDP synthase from Geobacillus stearothermophilus; (-)-germacrene D synthase from Solidago canadensis; 1,4-dithio-L-threitol; magnesium chloride / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction View Scheme

Yield

Multi-step reaction with 3 steps
1: Escherichia coli hydroxyethylthiazole kinase; ATP; pyruvate kinase / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction
2: isopentenyl phosphate kinase from Methanocaldococcus jannaschii; ATP; pyruvate kinase / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction
3: (2E,6E)-FDP synthase from Geobacillus stearothermophilus; (-)-germacrene D synthase from Solidago canadensis; 1,4-dithio-L-threitol; magnesium chloride / aq. buffer / 16 h / 20 °C / pH 8 / Enzymatic reaction
View Scheme

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