Products Categories
CAS No.: | 249289-07-4 |
---|---|
Name: | Diethyl 2-(4-octanoylphenethyl)-2-acetamidomalonate |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C25H37NO6 |
Molecular Weight: | 447.572 |
PSA: | 98.77000 |
LogP: | 4.55440 |
n-octanoic acid chloride
2-acetamido-1,3-diacetoxy-2-(2-phenylethyl)propane
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
With aluminum (III) chloride; 1,2-dichloro-ethane at 0 - 20℃; for 18.5h; Friedel-Crafts Acylation; | 81% |
With aluminium trichloride In 1,2-dichloro-ethane at 20℃; for 12h; Friedel-Crafts acylation; | 64% |
Stage #1: n-octanoic acid chloride With aluminum (III) chloride In 1,2-dichloro-ethane at -15 - -10℃; for 1.5h; Inert atmosphere; Stage #2: 2-acetamido-1,3-diacetoxy-2-(2-phenylethyl)propane In 1,2-dichloro-ethane at -15 - 20℃; for 19h; Inert atmosphere; |
2-acetylamino-2-phenylethylmalonic acid diethyl ester
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 2: pyridine / 16 h / 20 °C 3: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C 2: pyridine / 15 h / 20 °C 3: aluminum (III) chloride; 1,2-dichloro-ethane / 18.5 h / 0 - 20 °C View Scheme |
1-phenyl-2-bromoethane
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: pyridine / 16 h / 20 °C 4.1: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: caesium carbonate / dimethyl sulfoxide / 6 h / 65 °C 2: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C 3: pyridine / 15 h / 20 °C 4: aluminum (III) chloride; 1,2-dichloro-ethane / 18.5 h / 0 - 20 °C View Scheme |
2-acetylaminomalonic acid diethyl ester
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: pyridine / 16 h / 20 °C 4.1: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme |
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 16 h / 20 °C 2: 64 percent / AlCl3 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: pyridine / 15 h / 20 °C 2: aluminum (III) chloride; 1,2-dichloro-ethane / 18.5 h / 0 - 20 °C View Scheme |
2-acetylaminomalonic acid diethyl ester
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate / dimethyl sulfoxide / 6 h / 65 °C 2: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C 3: pyridine / 15 h / 20 °C 4: aluminum (III) chloride; 1,2-dichloro-ethane / 18.5 h / 0 - 20 °C View Scheme |
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
2-acetamido-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 2h; | 95% |
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; | 6.3 g |
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
1-[4-(3-amino-4-hydroxy-3-hydroxymethyl-butyl)-phenyl]-octan-1-one
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; methanol for 3h; Hydrolysis; Heating; | 51% |
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / 2 N aq. LiOH / methanol; tetrahydrofuran / 3 h / Heating 2: 66 percent / NaBH4 / ethanol / 3 h / 20 °C View Scheme |
2-acetamido-2-[2-(4-octanoylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / 2 N aq. LiOH / methanol; tetrahydrofuran / 3 h / Heating 2: 25 percent / H2NOH*HCl / ethanol; CHCl3 / 1.5 h / Heating View Scheme |