CAS No.25122-46-7,Clobetasol propionate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	25122-46-7
Name:	Clobetasol propionate
Article Data:	8

Formula:	C₂₅H₃₂ClFO₅
Molecular Weight:	466.977
Synonyms:	Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11b,17-dihydroxy-16b-methyl-,17-propionate (8CI);21-Chloro-21-deoxybetamethasone 17-propionate;CCl 4725;CGP 9555;Clobederm;Clobesol;Clobetasol 17-propionate;Clobex;Dermoval;Dermovate;Dermoxinale;GR 2/925;Karison;Olux;Skin Cap;Temovate;Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11b,16b)-;
EINECS:	246-634-3
Density:	1.28 g/cm³
Melting Point:	195.5-197 °C
Boiling Point:	569 °C at 760 mmHg
Flash Point:	297.9 °C
Appearance:	White crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	80.67000
LogP:	4.10310

Synthetic route

: C25H31ClO5

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
With hydrogen fluoride; potassium hydroxide In water; acetone at -40 - -30℃; for 6h; Temperature;	95%

: C25H31ClO5

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
With hydrogen fluoride In tetrahydrofuran; water at -5 - 0℃; Solvent;	94.3%
With hydrogen fluoride In chloroform; water at -40℃;	84%

: 1062-09-5
Betamethasone 17α,21-ethyl orthopropanoate

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
With chloro-trimethyl-silane In N,N-dimethyl-formamide

: C22H26O2

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: sodium hydroxide / -5 - 5 °C 1.2: 20 °C / Darkness 1.3: 20 °C 2.1: toluene-4-sulfonic acid / dichloromethane / 20 °C 3.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 4.1: hydrogen bromide / dichloromethane / 20 °C 4.2: Raney nickel / 20 °C 5.1: triethylamine; dmap / chloroform / 50 °C 6.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 7.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme

Yield

Multi-step reaction with 7 steps
1.1: sodium hydroxide / -5 - 5 °C
1.2: 20 °C / Darkness
1.3: 20 °C
2.1: toluene-4-sulfonic acid / dichloromethane / 20 °C
3.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C
4.1: hydrogen bromide / dichloromethane / 20 °C
4.2: Raney nickel / 20 °C
5.1: triethylamine; dmap / chloroform / 50 °C
6.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C
7.1: hydrogen fluoride / chloroform; water / -40 °C
View Scheme

: C24H31ClO3

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C 2.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 3.1: hydrogen bromide / dichloromethane / 20 °C 3.2: Raney nickel / 20 °C 4.1: triethylamine; dmap / chloroform / 50 °C 5.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 6.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C
2.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C
3.1: hydrogen bromide / dichloromethane / 20 °C
3.2: Raney nickel / 20 °C
4.1: triethylamine; dmap / chloroform / 50 °C
5.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C
6.1: hydrogen fluoride / chloroform; water / -40 °C
View Scheme

: C22H25ClO2

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide / tetrahydrofuran / 20 °C 2.1: hydrogen bromide / dichloromethane / 20 °C 2.2: Raney nickel / 20 °C 3.1: triethylamine; dmap / chloroform / 50 °C 4.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 5.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme

: C22H25ClO3

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: hydrogen bromide / dichloromethane / 20 °C 1.2: Raney nickel / 20 °C 2.1: triethylamine; dmap / chloroform / 50 °C 3.1: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 4.1: hydrogen fluoride / chloroform; water / -40 °C View Scheme

: 116846-77-6
21-Chloro-17α-hydroxy-16β-methylpregna-1,4,9(11)-triene-3,20-dione

: 25122-46-7
clobetasol-17-propionate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine; dmap / chloroform / 50 °C 2: 5,5-dibromohydantoin; perchloric acid / acetone / -5 - 5 °C 3: hydrogen fluoride / chloroform; water / -40 °C View Scheme

: 25122-46-7
clobetasol-17-propionate

: 80042-35-9
21-chloro-9α-fluoro-16β-methyl-11β,17α-dihydroxy-5β-pregnane-3,20-dione 17-propionate

Conditions

Conditions	Yield
palladium In 4,4-dichlorobutan-2-one; ethyl acetate
palladium In 4,4-dichlorobutan-2-one; ethyl acetate

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Chemistry

IUPAC Name: [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Molecular Weight: 466.969983 [g/mol]
Molecular Formula: C₂₅H₃₂ClFO₅
XLogP3: 3.8
H-Bond Donor: 1
H-Bond Acceptor: 6
EINECS: 246-634-3
Product Categories: Organics; Intermediates & Fine Chemicals; Pharmaceuticals
Index of Refraction: 1.56
Molar Refractivity: 117.75 cm³
Molar Volume: 364.1 cm³
Surface Tension: 48.9 dyne/cm
Density: 1.28 g/cm³
Flash Point: 297.9 °C
Enthalpy of Vaporization: 98.07 kJ/mol
Boiling Point: 569 °C at 760 mmHg
Vapour Pressure: 2.58E-15 mmHg at 25 °C
Water Solubility: 3.860 mg/L at 25 °C
Appearance: White Crystalline Powder
Melting Point: 195.5-197 °C
Classification Code of Clobetasol propionate (CAS NO.25122-46-7): Anti-inflammatory; Drug / Therapeutic Agent; Hormone; Reproductive Effect

Uses

Clobetasol propionate (CAS NO.25122-46-7) is used for the treatment of various skin disorders including eczema, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules).

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	118mg/kg (118mg/kg)	Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse	LD50	oral	> 3gm/kg (3000mg/kg)	Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse	LD50	subcutaneous	81700ug/kg (81.7mg/kg)	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	intraperitoneal	351mg/kg (351mg/kg)	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	oral	> 3gm/kg (3000mg/kg)	Drugs in Japan Vol. 6, Pg. 241, 1982.
rat	LD50	subcutaneous	366mg/kg (366mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 1066, 1978.

Safety Profile

Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
Poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻ and Cl⁻.

Specification

Clobetasol propionate (CAS NO.25122-46-7), its Synonyms are 21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)- ; 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate ; Butavate ; Clobesol ; Clobetasol 17-propionate ; Clobex ; Cormax ; Dermoval ; Dermovate ; Dermoxinale ; Embeline ; Embeline E ; Olux-E ; Temovate ; Temovate E ; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate ; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)- .

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