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CAS No.: | 2538-50-3 |
---|---|
Name: | 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C10H14N.ClH |
Molecular Weight: | 199.68 |
Synonyms: | 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (9CI);Propiophenone,3-(methylamino)-, hydrochloride (6CI,7CI,8CI);3-(N-Methylamino)propiophenone hydrochloride;3-Methylaminopropiophenone; |
EINECS: | C10H14ClNO |
Density: | 1.002g/cm3 |
Melting Point: | 139-141 °C(Solv: acetone (67-64-1)) |
Boiling Point: | 274.7°C at 760 mmHg |
Flash Point: | 114.1°C |
PSA: | 29.10000 |
LogP: | 2.67170 |
formaldehyd
methylamine hydrochloride
acetophenone
β-Methylaminoethyl phenyl ketone hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 110℃; for 20h; Sealed tube; | 70% |
With hydrogenchloride In ethanol; water at 110℃; for 20h; | 39.8% |
With hydrogenchloride In ethanol at 110℃; | |
With toluene-4-sulfonic acid In ethanol at 110℃; for 20h; |
β-Methylaminoethyl phenyl ketone hydrochloride
(R)-N-methyl-3-phenyl-3-hydroxypropylamine
Conditions | Yield |
---|---|
With Rh[((R,R)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 48h; Autoclave; enantioselective reaction; | 93% |
Multi-step reaction with 2 steps 1: potassium borohydride / tetrahydrofuran / 66 °C 2: sodium hydrogencarbonate / chloroform; water View Scheme |
β-Methylaminoethyl phenyl ketone hydrochloride
(S)-N-methyl-3-amino-1-phenyl-1-propanol
Conditions | Yield |
---|---|
With Rh[((S,S)-BenzP*)(cod)]SbF6; hydrogen; caesium carbonate; zinc(II) chloride In methanol at 20℃; under 19001.3 Torr; for 20h; Autoclave; enantioselective reaction; | 92% |
With hydrogen; potassium carbonate; [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h; | 90% |
With [Rh((S,S)-BenzP*)(cod)]SbF6; hydrogen; magnesium sulfate; potassium carbonate In ethyl acetate at 50℃; under 37503.8 Torr; for 1h; enantioselective reaction; | 80% |
β-Methylaminoethyl phenyl ketone hydrochloride
3-methylamino-1-phenylpropan-1-ol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 20℃; for 1h; | 90% |
With sodium tetrahydroborate In methanol at 20℃; for 1h; |
β-Methylaminoethyl phenyl ketone hydrochloride
3-methylamino-1-phenyl-propan-1-ol; hydrochloride
Conditions | Yield |
---|---|
With potassium borohydride In tetrahydrofuran at 66℃; | 82% |
β-Methylaminoethyl phenyl ketone hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaBH4 / methanol / 1 h / 20 °C 2: CH2Cl2 / 0.17 h / 0 °C View Scheme |
β-Methylaminoethyl phenyl ketone hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Rh[((S,S)-BenzP*)(cod)]SbF6; zinc(II) chloride; caesium carbonate; hydrogen / methanol / 20 h / 20 °C / 19001.3 Torr / Autoclave 2: dichloromethane / 0.17 h / 0 °C View Scheme |
β-Methylaminoethyl phenyl ketone hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 55 °C / Inert atmosphere 2.2: 1 h / 90 °C View Scheme |
β-Methylaminoethyl phenyl ketone hydrochloride
4-(3-(methylamino)-1-phenylpropyl)phenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2: trifluoroacetic acid / 48 h / 20 °C View Scheme |
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IUPAC Name: 3-(Methylamino)-1-phenylpropan-1-one chloride
Synonyms of 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3): 3-Methylamino-1-phenylpropan-1-one hydrochloride ;3-(Methylamino)-1-phenyl-1-propanone hydrochloride
CAS NO: 2538-50-3
Molecular Formula of 1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3): C10H14ClNO
Molecular Weight: 199.67726
Molecular Structure:
SMILES: CNCCC(=O)c1ccccc1.Cl
InChI: InChI=1/C10H13NO.ClH/c1-11-8-7-10(12)9-5-3-2-4-6-9;/h2-6,11H,7-8H2,1H3;1H
InChIKey: VIHLSOFMDHEDRK-UHFFFAOYAP
Std. InChI: InChI=1S/C10H13NO.ClH/c1-11-8-7-10(12)9-5-3-2-4-6-9;/h2-6,11H,7-8H2,1H3;1H
Std. InChIKey: VIHLSOFMDHEDRK-UHFFFAOYSA-N
1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (1:1) (CAS NO.2538-50-3) is used as antidepressant fluoxetine intermediate.