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25389-94-0

Basic Information
CAS No.: 25389-94-0
Name: Kanamycin sulfate
Molecular Structure:
Molecular Structure of 25389-94-0 (Kanamycin sulfate)
Formula: C18H36N4O11•H2O4S
Molecular Weight: 582.66
Synonyms: Kanamycin Mono Sulfate;Kanamycin Mono Sulphate;Prestwick_596;Otokalixin;Kanacedin;Kantrex;Kanabristol;Cantrex;Kanatrol;Kanaqua;Kantrex (TN);Kanescin;Ophtalmokalixan;Cristalomicina;Kannasyn;Klebcil;133-92-6;Kanasig;Kanamytrex;Kantrim;2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-oxane-3,4,5-triol; sulfuric acid;
EINECS: 246-933-9
Density: 1.3619 (rough estimate)
Melting Point: 250 °C
Boiling Point: 943.2 °C at 760 mmHg
Flash Point: 524.2 °C
Solubility: Soluble in water at 10mg/ml
Appearance: Off-white powder
Hazard Symbols: ToxicT
Risk Codes: 61
Safety: 22-24/25-45
Transport Information:
PSA: 365.59000
LogP: -4.06220
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Chemistry

Molecular Formula: C18H38N4O15S
Formula Weight: 582.58
mp : 250°C
refractive index : 117.5 ° (C=1, H2O) 
storage temp. : 2-8°C
solubility : H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
KANAMYCIN SULFATE is an aminoglycoside antibiotic, available in both oral and intravenous forms.

Uses

KANAMYCIN SULFATE is used in molecular biology as a selective agent most commonly to isolate bacteria (e.g., E. coli) which have taken up genes (e.g., of plasmids) coupled to a gene coding for kanamycin resistance (primarily Neomycin phosphotransferase II [NPT II/Neo]).

Toxicity Data With Reference

1.   

ims-cld TDLo:390 mg/kg:EAR

   JOPDAB    Journal of Pediatrics. 60 (1962),230.
2.   

orl-rat LD50:>4 g/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
3.   

ipr-rat LD50:3200 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
4.   

ivn-rat LD50:225 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
5.   

orl-mus LD50:17,500 mg/kg

   DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),173.
6.   

ipr-mus LDLo:1914 mg/kg

   AIMDAP    Archives of Internal Medicine. 119 (1967),493.
7.   

scu-mus LD50:2150 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.
8.   

ivn-mus LD50:180 mg/kg

   ANTBAL    Antibiotiki. 24 (1979),60.
9.   

ims-mus LDLo:1914 mg/kg

   AIMDAP    Archives of Internal Medicine. 119 (1967),493.
10.   

ivn-rbt LD50:550 mg/kg

   JJANAX    Japanese Journal of Antibiotics. 28 (1975),415.

Safety Profile

Hazard Codes : T
Risk Statements : 61
Safety Statements : 22-24/25-45
WGK Germany : 3
RTECS : NZ3225030
A poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Human systemic effects: hearing acuity changes. When heated to decomposition it emits very toxic NOx and SOx. See also KANAMYCIN SULFATE (1:1) SALT.