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25655-41-8

Basic Information
CAS No.: 25655-41-8
Name: Povidone iodine
Molecular Structure:
Molecular Structure of 25655-41-8 (Povidone iodine)
Formula: (C6H9NO)x. xI2
Molecular Weight: 364.95100
Synonyms: Polyvinylpyrrolidone - iodine complex;Tegodyne;Poly(1-(2-Oxo-1-Pyrrolidinyl)Ethylene)-Iodine Complex;Povidoneiodine;1-Ethenyl-2-pyrrolidinone homopolymer compound with iodine;1-Vinyl-2-pyrrolidinone polymer, compd. with iodine;2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine;Argentyne;Povidone Iodine Solution;Povidone-iodine;
EINECS: 215-034-3
Density:
Melting Point: 300oC
Boiling Point: 217.6oC at 760 mmHg
Flash Point: 93.9oC
Solubility: Soluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether.
Appearance: A red-brown crystalline powder
Hazard Symbols:
Risk Codes:
Safety: S24/25
Transport Information:
PSA: 20.31000
LogP: 2.46160
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Chemistry

Povidone iodine's Molecular formula: (C6H9NO)n·xI
Povidone iodine's Molar mass:  variable
Synonyms: 2-Pyrrolidinone; 1-ethenyl-homopolymer; compd. with iodine; Betadine; Efo-dine; Polyvinylpyrrolidone-iodine complex; PVP-I(Povidone iodine/solution)
Povidone iodine (PVP-I) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis.
 

History

Povidone iodine was discovered at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. They carried out in vitro tests to demonstrate antibacterial activity, and found that the complex was less toxic than tincture of iodine in mice. Human clinical trials showed the product to be superior to other iodine formulations.
It was first sold in 1955, and has since become the universally preferred iodine disinfectant.

Uses

Povidone iodine has been broadly used for the prevention and treatment of skin infections, and the treatment of wounds.
Povidone iodine has found broad application in medicine as a surgical scrub; for pre- and post-operative skin cleansing; for the treatment and prevention of infections in wounds, ulcers, cuts and burns; for the treatment of infections in decubitus ulcers and stasis ulcers; in gynecology for vaginitis associated with candidal, trichomonal or mixed infections.
 

Toxicity Data With Reference

RTECS  TR1579600

Safety Profile

Safety Statements  24/25-22

Safety Info
Safety Statements: S24/25
HS Code: 3808940010

 

Specification

Povidone-iodine (PVP-I), brand name Wokadine, Pyodine, and Betadine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis.
This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. They carried out tests in vitro to demonstrate anti-bacterial activity, and found that the complex was less toxic in mice than tincture of iodine.
Human clinical trials showed the product to be superior to other iodine formulations.
Betadine was immediately marketed, and has since become the universally preferred iodine antiseptic.
It is on the WHO Model List of Essential Medicines, the most important products needed in a basic health system.

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