CAS No.258506-66-0,2-Chloro-6-iodopyridine Suppliers

Products Categories

Pharmaceutical (52)
Organic Chemicals (13)
Others (6)
Reagent (3)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	258506-66-0
Name:	2-Chloro-6-iodopyridine
Article Data:	7

Formula:	C₅H₃ClIN
Molecular Weight:	239.443
Synonyms:	2-Chloro-iodopyridine;
EINECS:	145-896-5
Density:	2.052 g/cm³
Melting Point:	42-43 °C(lit.)
Boiling Point:	255.513 °C at 760 mmHg
Flash Point:	108.331 °C
Hazard Symbols:	Xi; Xn
Risk Codes:	22-41-43
Safety:	26-36/37/39
PSA:	12.89000
LogP:	2.33960

Synthetic route

: 109-09-1
2-chloropyridine

: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
With n-butyllithium; 2-(N,N-dimethylamino)ethanol; iodine at -78℃;	91%
Stage #1: 2-chloropyridine With n-butyllithium; BuLi-LiDMAE In hexane at -78℃; for 1h; Metallation; Stage #2: With iodine In tetrahydrofuran at -78 - 0℃; for 1h; Condensation;	80%
With n-butyllithium; iodine; lithium 2-(dimethylamino)ethanolate	80%

: 5140-72-7
2-bromo-6-chloro-pyridine

: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
Stage #1: 2-bromo-6-chloro-pyridine With n-butyllithium In diethyl ether; hexane at -75℃; for 0.75h; Stage #2: With iodine In tetrahydrofuran; diethyl ether; hexane at -75℃; for 0.75h;	84%
Stage #1: 2-bromo-6-chloro-pyridine With n-butyllithium In diethyl ether at -78℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: With iodine at 20℃; for 12h; Inert atmosphere; Schlenk technique;	80%

: 109-09-1
2-chloropyridine

A: 153034-86-7
2-chloro-4-iodopyridine

B: 2-chloro-3,6-diiodopyridine

C: 78607-36-0
2-chloro-3-iodopyridine

D: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
Stage #1: 2-chloropyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl2-N,N,N’,N’-tetramethylethylenediamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran Inert atmosphere; regioselective reaction;	A 9 %Spectr. B 15% C 43 %Spectr. D 30%

...Expand

: 109-09-1
2-chloropyridine

A: 153034-86-7
2-chloro-4-iodopyridine

B: 116195-81-4
2,5-di-iodopyridine

C: 2-chloro-3,6-diiodopyridine

D: 78607-36-0
2-chloro-3-iodopyridine

E: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
Stage #1: 2-chloropyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl2-N,N,N’,N’-tetramethylethylenediamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran Inert atmosphere; regioselective reaction;	A 6 %Spectr. B 4% C 3% D 41 %Spectr. E 10%

...Expand

: 2402-78-0
2,6-dichloropyridine

A: 53710-17-1
2,6-diiodo-pyridine

B: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
With hydrogen iodide; sodium iodide at 100℃; for 14h; Substitution; Title compound not separated from byproducts;

: 626-05-1
2,6-Dibromopyridine

: 258506-66-0
2-chloro-5-iodo-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iPrMgCl / tetrahydrofuran / 2 h / 0 - 25 °C 1.2: 73 percent / CF2ClCFCl2 / tetrahydrofuran / 1.75 h / 0 - 25 °C 2.1: nBuLi / diethyl ether; hexane / 0.75 h / -75 °C 2.2: 84 percent / I2 / hexane; diethyl ether; tetrahydrofuran / 0.75 h / -75 °C View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere; Schlenk technique 1.2: 12 h / 20 °C / Inert atmosphere; Schlenk technique 2.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere; Schlenk technique 2.2: 12 h / 20 °C / Inert atmosphere; Schlenk technique View Scheme

: 2101-86-2
p-methylazidobenzene

: 258506-66-0
2-chloro-5-iodo-pyridine

: 6-chloro-N-(p-tolyl)pyridin-2-amine

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate; bathophenanthroline; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 27℃; for 20h; Irradiation;	98%

: 18412-57-2
p-tolyltriethoxysilane

: 258506-66-0
2-chloro-5-iodo-pyridine

A: 864913-65-5
2-chloro-6-(4-methylphenyl)pyridine

B: 53344-72-2
6,6'-dichloro-2,2'-bipyridine

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride In N,N-dimethyl-formamide at 120℃; for 12h; Hiyama Coupling; Inert atmosphere;	A 70% B n/a

...Expand

: 463-49-0
1,2-propanediene

: 98-88-4
benzoyl chloride

: 258506-66-0
2-chloro-5-iodo-pyridine

: N-[2-(6-chloro-pyridin-2-yl)-allyl]-benzamide

Conditions

Conditions	Yield
Stage #1: 1,2-propanediene; 2-chloro-5-iodo-pyridine With trifuran-2-yl-phosphane; Fmoc-deprotected Rink Amide MBHA resin; potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0) In N,N-dimethyl-formamide at 80℃; for 24h; Stage #2: benzoyl chloride With triethylamine In dichloromethane at 0 - 20℃; for 24h; Stage #3: With trifluoroacetic acid In dichloromethane at 20℃; for 0.333333h;	68%

...Expand

: 213318-44-6
N-Boc-indole-2-boronic acid

: 258506-66-0
2-chloro-5-iodo-pyridine

: 937810-25-8
C13H9ClN2

Conditions

Conditions	Yield
Stage #1: N-Boc-indole-2-boronic acid; 2-chloro-5-iodo-pyridine With sodium carbonate; bis(triphenylphosphine)palladium(II)-chloride In 1,2-dimethoxyethane; water Suzuki cross-coupling reaction; Heating; Stage #2: With silica gel In dichloromethane at 80℃; Further stages.;	66%

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:72 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 258506-66-0

Specification

The 2-Chloro-6-iodopyridine with its cas register number is 258506-66-0. It also can be called as Pyridine,2-chloro-6-iodo- and the IUPAC Name about this chemical is 2-chloro-6-iodopyridine. It belongs to the following product categories, such as compounds of pyridine, Halides, Pyridines and so on.

Physical properties about 2-Chloro-6-iodopyridine are: (1)ACD/LogP: 1.97; (2)ACD/LogD (pH 5.5): 1.97; (3)ACD/LogD (pH 7.4): 1.97; (4)ACD/BCF (pH 5.5): 18.62; (5)ACD/BCF (pH 7.4): 18.62; (6)ACD/KOC (pH 5.5): 282.24; (7)ACD/KOC (pH 7.4): 282.24; (8)#H bond acceptors: 1; (9)Polar Surface Area: 12.89Å²; (10)Index of Refraction: 1.642; (11)Molar Refractivity: 42.14 cm³; (12)Molar Volume: 116.6 cm³; (13)Polarizability: 16.7x10^-24cm³; (14)Surface Tension: 51.7 dyne/cm; (15)Enthalpy of Vaporization: 47.31 kJ/mol; (16)Vapour Pressure: 0.026 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and it may cause sensitization by skin contact, it has risk of serious damage to the eyes. When you are using it, wear protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=NC(=C1)I)Cl
(2)InChI: InChI=1S/C5H3ClIN/c6-4-2-1-3-5(7)8-4/h1-3H
(3)InChIKey: LSAOLINSZGYDOV-UHFFFAOYSA-N