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CAS No.: | 2627-69-2 |
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Name: | AICAR |
Article Data: | 25 |
Molecular Structure: | |
Formula: | C9H14N4O5 |
Molecular Weight: | 258.234 |
Synonyms: | Imidazole-4-carboxamide,5-amino-1-b-D-ribofuranosyl- (6CI,7CI,8CI);1-Ribosyl-4-carboxamido-5-aminoimidazole;1-b-D-Ribofuranosyl-5-amino-4-imidazolecarboxamide;5-Amino-1-ribosyl-4-imidazolecarboxamide;5-Amino-1-b-D-ribofuranosylimidazole-4-carboxamide;5-Amino-4-imidazolecarboxamide ribofuranoside;5-Amino-4-imidazolecarboxamideriboside;5-Aminoimidazole-4-carboxamide 1-(b-D-ribofuranoside);AIC-Riboside;AICA-Riboside;Acadesine;Arasine;NSC 105823;GP 1-110; |
EINECS: | 220-097-5 |
Density: | 2.06 g/cm3 |
Melting Point: | 214-215 °C |
Boiling Point: | 726.3 °C at 760 mmHg |
Flash Point: | 393.1 °C |
Solubility: | >10 mg/mL in water |
Appearance: | tan powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 156.85000 |
LogP: | -1.54280 |
5-amino-1-(5′-O-tert-butyldimethylsilyl-2′,3′-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxamide
AICA riboside
Conditions | Yield |
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With trifluoroacetic acid In acetonitrile at 0 - 20℃; for 17h; | 78% |
9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-(2-methoxy-ethoxymethyl)-1,9-dihydro-purin-6-one
AICA riboside
Conditions | Yield |
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With sodium hydroxide for 1h; Heating; | 73% |
Stage #1: 9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-(2-methoxy-ethoxymethyl)-1,9-dihydro-purin-6-one With sodium hydroxide; water for 1h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; | 70% |
5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carbonitrile
AICA riboside
Conditions | Yield |
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With sodium hydroxide at 100℃; for 2.5h; | 72% |
5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
AICA riboside
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In acetic acid under 760 Torr; for 1.5h; Ambient temperature; | 42% |
With hydrogen; palladium on activated charcoal In water; acetic acid at 23℃; under 760 Torr; for 1h; | 42% |
5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide
AICA riboside
Conditions | Yield |
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With ethanol; water; nickel |
5-nitro-1-β-D-ribofuranosyl-1H-imidazole-4-carboxylic acid amide
AICA riboside
Conditions | Yield |
---|---|
With water; platinum Hydrogenation; |
5-amino-1-(β-D-ribofuranosyl)imidazole-4-(N-benzyl)carboxamide
AICA riboside
Conditions | Yield |
---|---|
With ammonia; sodium amide |
Conditions | Yield |
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With ethyl acetate; platinum Hydrogenation.Behandeln mit -cyan-essigsaeure-amid und metanol. Natriummethylat; |
9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-methoxymethyl-1,9-dihydro-purin-6-one
AICA riboside
Conditions | Yield |
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With sodium hydroxide Heating; |
AICA riboside
Conditions | Yield |
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With sodium hydroxide Heating; |
The Acadesine, with the CAS registry number 2627-69-2, has the systematic name 5-amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide. Its molecular formula is C9H14N4O5 and its product categories are Bases & Related Reagents; Carbohydrates & Derivatives; Nucleotides; Protein Kinase storage Temp. However, keep it at -20 °C.
Other characteristics of the Acadesine can be summarised as followings: (1)ACD/LogP: -3.87; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -3.87; (4)ACD/LogD (pH 7.4): -3.87; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 9; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 78.29 Å2; (13)Index of Refraction: 1.821; (14)Molar Refractivity: 54.55 cm3; (15)Molar Volume: 125.2 cm3; (16)Polarizability: 21.62×10-24cm3; (17)Surface Tension: 106.5 dyne/cm; (18)Density: 2.06 g/cm3; (19)Flash Point: 393.1 °C; (20)Enthalpy of Vaporization: 111.33 kJ/mol; (21)Boiling Point: 726.3 °C at 760 mmHg; (22)Vapour Pressure: 3.83E-22 mmHg at 25°C.
Uses of this chemical: The Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. It is also an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: O=C(c1ncn(c1N)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N
2.InChI: InChI=1/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
3.InChIKey: RTRQQBHATOEIAF-UUOKFMHZBE