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| CAS No.: | 2647-50-9 |
|---|---|
| Name: | Flubromazepam |
| Article Data: | 13 |
| Molecular Structure: | |
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| Formula: | C15H10BrFN2O |
| Molecular Weight: | 333.16 |
| Synonyms: | 2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-fluorophenyl)-1,3-dihydro;7-Brom-5-<2-fluor-phenyl>-1.3-dihydro-2H-1.4-benzodiazepin-2-on;7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Brom-5-<2-fluor-phenyl>-2-oxo-1,2-dihydro-<1,4>benzodiazepin;7-bromo-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;7-Brom-5-<2-fluor-phenyl>-3H-1,4-benzodiazepin-2(1H)-on;7-bromo-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one;7-bromo-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; |
| Density: | 1.58±0.1 g/cm3(Predicted) |
| Melting Point: | 189-190℃ |
| Boiling Point: | 465.7±45.0 °C(Predicted) |
| PSA: | 44.95000 |
| LogP: | 2.89840 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 1647-74-1
5-bromo-2-bromoacetamido-2'-fluorobenzophenone
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| With ammonia In methanol for 16h; Heating / reflux; | 56.8% |
| With ammonia for 5h; Heating; | 4.5 g |
| With ammonia In methanol for 18h; | 98.6 mg |
| With ammonia In methanol at 0 - 20℃; | 68 mg |
- 1479-58-9
5-bromo-2'-fluoro-2-aminobenzophenone
- 598-21-0
2-Bromoacetyl bromide
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Stage #1: 5-bromo-2'-fluoro-2-aminobenzophenone; 2-Bromoacetyl bromide With sodium hydrogencarbonate In dichloromethane Stage #2: With ammonia In methanol Heating / reflux; | |
| Stage #1: 5-bromo-2'-fluoro-2-aminobenzophenone; 2-Bromoacetyl bromide With sodium hydrogencarbonate In dichloromethane Stage #2: With ammonia In methanol Heating / reflux; |
- 2824-08-0
N(1)-[4-bromo-2-[(2-fluorophenyl)carbonyl]phenyl]glycinamide
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| With acetic acid In ethanol for 0.25h; Heating / reflux; |
- 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 2: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 3: ammonia / methanol / 18 h View Scheme |
- 1479-58-9
5-bromo-2'-fluoro-2-aminobenzophenone
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2: ammonia / methanol / 18 h View Scheme | |
| Multi-step reaction with 2 steps 1: sodium carbonate / dichloromethane; water / 2 h / 0 °C 2: ammonia / methanol / 0 - 20 °C View Scheme |
- 87-48-9
5-Bromo-1H-indole-2,3-dione
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 50 °C 1.2: pH Ca. 4 2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 4.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 5.1: ammonia / methanol / 18 h View Scheme |
- 74189-16-5
2-amino-5-bromobenzoic acid hydrochloride
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C / Inert atmosphere 3: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 4: ammonia / methanol / 18 h View Scheme |
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
- 10329-38-1
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide
| Conditions | Yield |
|---|---|
| With peracetic acid In dichloromethane for 4.5h; Ambient temperature; | 80.9% |
- 123-38-6
propionaldehyde
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
| Conditions | Yield |
|---|---|
| Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 4h; Stage #2: propionaldehyde In methanol at 20℃; | 62% |
- 2999-46-4
Ethyl isocyanoacetate
- 2647-50-9
7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
- 612526-24-6
ethyl 8-bromo-6-(2'-fluorophenyl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With diethyl chlorophosphate In tetrahydrofuran at 0℃; for 0.5h; Stage #3: Ethyl isocyanoacetate In tetrahydrofuran at 0℃; for 1h; | 58% |
| Stage #1: 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: With diethyl chlorophosphate In tetrahydrofuran at 0℃; for 0.5h; Stage #3: Ethyl isocyanoacetate With sodium hydride; acetic acid more than 3 stages; |
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