CAS No.26787-78-0,Amoxicillin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	26787-78-0
Name:	Amoxicillin
Article Data:	30
Cas Database

Formula:	C₁₆H₁₉N₃O₅S
Molecular Weight:	365.41
Synonyms:	4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D- (8CI);Eupensol;Excillin;Farconcil;Fisamox;Foxolin;Fullcilina;Gemox;Gimalxina;Gomcillin;Gramidil;Grunamox;Hiconcil;Hipen;Histocillin;Hosboral;Imacillin;Imaxilin;Imox;Imoxil;Intermox;Jerramcil;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2a,5a,6b(S*)]]-;6-[D-(-)-p-Hydroxy-a-aminobenzyl]penicillin;6-[D-a-Amino-a-(4-hydroxyphenyl)acetamido]penicillanicacid;A-Gram;Actimoxi;Agerpen;Alfamox;Almodan;Alphamox;Amagesen Solutab;Amodex;Amoflux;Amopenixin;Amoxa;Amoxal;Amoxapen;Amoxaren;Amoxi;Amoxi-Mast;Amoxicilina;Amoxidal;Amoxiden;Amoxil;Amoxin;Amoxipen;Amoxtrex;Amoxy;Amoxypen;Ampidroxyl;Ampy-Penyl;Anemol;Anemolin;Apitart;Apo-Amoxi;Ardine;Aspenil;Audumic;BLP1410;BRL 2333;Bactox;Betamox;Bimox;Biomox;Bioxidona;Bioxyllin;Cabermox;Cilamox;Clamox;Clamoxyl;Coamoxin;Comoxyl;D-(-)-a-Amino-p-hydroxybenzyl penicillin;D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid;D-Amoxicillin;Delacillin;Efpenix;Efpinex;Eupen;
EINECS:	248-003-8
Density:	1.54 g/cm³
Melting Point:	140 °C
Boiling Point:	743.2 °C at 760 mmHg
Flash Point:	403.3 °C
Solubility:	4g/L at 25℃
Appearance:	solid
Hazard Symbols:	Xn, Xi
Risk Codes:	42/43
Safety:	22-36/37
PSA:	158.26000
LogP:	1.05280

Synthetic route

: C31H29N3O7S

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol; water for 3h;	62%

: 551-16-6
6-Aminopenicillanic Acid

: 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
at 30℃; for 3h; Pseudomonas melanogenum KY 3987 and KY 8540; Yield given;
With penicillin acylasefrom Escherichia coli; water

: 551-16-6
6-Aminopenicillanic Acid

: 57591-61-4, 68697-60-9, 127369-30-6, 134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
With iso-butanol In water at 20℃; Xanthomonas citri K24, pH = 6-7; Yield given;

: 75-21-8
oxirane

: cefprozil

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
In sodium amoxycillin; water; amoxycillin trihydrate; cefaclor monohydrate

: ethoxy carbonyl D-α-(1-carbomethoxy-propenyl)amino p-hydroxy phenyl acetate

: 7732-18-5
water

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In acetone

: 32462-30-9
(S)-hydroxyphenylglycine

: 3282-30-2
pivaloyl chloride

: 141-97-9
ethyl acetoacetate

: 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
With triethylamine In ethanol; dichloromethane

...Expand

triethylamine (TEA): triethylamine (TEA)

: 82095-48-5, 95510-67-1
D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt

3-trimethylsilyl-2-oxazolidinone (TMSO): 3-trimethylsilyl-2-oxazolidinone (TMSO)

: 3282-30-2
pivaloyl chloride

: 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid

: 26787-78-0
amoxicillin

Conditions

Conditions	Yield
In dichloromethane; ISOPROPYLAMIDE; water

...Expand

: 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid

: 26787-78-0
amoxicillin

: 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid

A: 26787-78-0
amoxicillin

B: 760-67-8
2-ethylhexanoic acid chloride

: Methoxycarbonyl D-α-(1-carbomethoxypropen-2-yl)amino-p-hydroxyphenyl-acetate

: 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid

: 10416-58-7
N,N-bis(trimethylsilyl)acetamide

: 26787-78-0
amoxicillin

...Expand

Raw Materials

551-16-6

822-39-9

Downstream Products

106-57-0

73590-58-6

34642-77-8

Total:273 Page 1 of 8 1 2 3 4 5 6 …8 Next>>

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Chemistry

Structure of Amoxicillin (CAS NO.26787-78-0):

IUPAC Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Empirical Formula: C₁₆H₁₉N₃O₅S
Molecular Weight: 365.4042
EINECS: 248-003-8
Index of Refraction: 1.701
Molar Refractivity: 91.47 cm³
Molar Volume: 236.2 cm³
Polarizability: 36.26×10^-24cm³
Surface Tension: 85.3 dyne/cm
Density: 1.54 g/cm³
Flash Point: 403.3 °C
Enthalpy of Vaporization: 113.73 kJ/mol
Boiling Point: 743.2 °C at 760 mmHg
Vapour Pressure: 3.39E-23 mmHg at 25°C
Stability: Stable. Incompatible with strong oxidizing agents.
Product Categories: Antibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity

Uses

Amoxicillin can be used as broad-spectrum semi-synthetic PENICILLIN. It is active against gram-positive and -negative bacteri. Clinic for the treatment of tonsillitis, laryngitis, pneumonia, chronic bronchitis, urinary tract infections, skin and soft tissue infections, septic pleurisy, hepatobiliary system infections, sepsis, typhoid, dysentery. The antimicrobial spectrum of goods for drugs, and its role and application of both PENICILLIN and Benzyl chloride similar strengths of the serum protein binding rate and blood concentration more than twice as high as ampicillin.

Production

6-APA and N-(3-ethoxycarbonyl-1-methyl vinyl) Sodium p-hydroxyphenylglycine derived by condensation. 6- APA is the production of a wide range of semi-synthetic PENICILLIN important raw materials. Large industrial use of microorganisms PENICILLIN lactamase cracker natural PENICILLIN (PENICILLIN G or PENICILLIN V) approach to the admission system.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	300mg/kg (300mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Clinical Pediatrics Vol. 32, Pg. 735, 1993.
child	TDLo	oral	682mg/kg (682mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: HEMATURIA	Clinical Pediatrics Vol. 32, Pg. 735, 1993.
man	TDLo	oral	7143ug/kg (7.143mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Allergy. Vol. 52(Suppl,
man	TDLo	oral	40mg/kg/4D (40mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Lancet. Vol. 2, Pg. 707, 1978.
mouse	LD50	intracrebral	> 500mg/kg (500mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS	Chemotherapy Vol. 26, Pg. 196, 1980.
mouse	LD50	intraperitoneal	3590mg/kg (3590mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
mouse	LD50	oral	> 25gm/kg (25000mg/kg)		Drugs in Japan Vol. 6, Pg. 38, 1982.
mouse	LD50	subcutaneous	> 20mg/kg (20mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
rat	LD50	intraperitoneal	2870mg/kg (2870mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.
rat	LD50	oral	> 15gm/kg (15000mg/kg)		Drugs in Japan Vol. 6, Pg. 38, 1982.
rat	LD50	subcutaneous	> 8gm/kg (8000mg/kg)		Drugs in Japan Vol. -, Pg. 59, 1990.

Safety Profile

Hazard Codes : Harmful Xn, Irritant Xi
Risk Statements : 42/43
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements : 22-36/37
S22:Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
WGK Germany : 2
RTECS : XH8300000

Standards and Recommendations

Purity of amoxicillin: 98.00%

Specification

Amoxicillin , its cas register number is 26787-78-0. It also can be called 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid ; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin ; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid ; Amoclen ; Amolin ; Amopenixin ; Amoxi ; Amoxi-Mast ;Amoxicaps ; Amoxicilina ; Amoxicillin pediatric ; Amoxicilline ; Amoxicillinum Amoxiden ; Amoxil ; Amoxivet ; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin ; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid ; D-Amoxicillin ; Delacillin ; DisperMox ; Hiconcil ; Histocillin ; Ibiamox ; Imacillin ; Larotid ; Metafarma capsules ; Metifarma capsules ; Moxacin ; Moxal ; Wymox ; alpha-Amino-p-hydroxybenzylpenicillin ; p-Hydroxyampicillin .