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26787-78-0

Basic Information
CAS No.: 26787-78-0
Name: Amoxicillin
Molecular Structure:
Molecular Structure of 26787-78-0 (Amoxicillin)
Formula: C16H19N3O5S
Molecular Weight: 365.40
Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D- (8CI);Eupensol;Excillin;Farconcil;Fisamox;Foxolin;Fullcilina;Gemox;Gimalxina;Gomcillin;Gramidil;Grunamox;Hiconcil;Hipen;Histocillin;Hosboral;Imacillin;Imaxilin;Imox;Imoxil;Intermox;Jerramcil;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2a,5a,6b(S*)]]-;6-[D-(-)-p-Hydroxy-a-aminobenzyl]penicillin;6-[D-a-Amino-a-(4-hydroxyphenyl)acetamido]penicillanicacid;A-Gram;Actimoxi;Agerpen;Alfamox;Almodan;Alphamox;Amagesen Solutab;Amodex;Amoflux;Amopenixin;Amoxa;Amoxal;Amoxapen;Amoxaren;Amoxi;Amoxi-Mast;Amoxicilina;Amoxidal;Amoxiden;Amoxil;Amoxin;Amoxipen;Amoxtrex;Amoxy;Amoxypen;Ampidroxyl;Ampy-Penyl;Anemol;Anemolin;Apitart;Apo-Amoxi;Ardine;Aspenil;Audumic;BLP1410;BRL 2333;Bactox;Betamox;Bimox;Biomox;Bioxidona;Bioxyllin;Cabermox;Cilamox;Clamox;Clamoxyl;Coamoxin;Comoxyl;D-(-)-a-Amino-p-hydroxybenzyl penicillin;D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid;D-Amoxicillin;Delacillin;Efpenix;Efpinex;Eupen;
EINECS: 248-003-8
Density: 1.54 g/cm3
Melting Point: 140 °C
Boiling Point: 743.2 °C at 760 mmHg
Flash Point: 403.3 °C
Solubility:
Appearance: solid
Hazard Symbols: HarmfulXn, IrritantXi
Risk Codes: 42/43
Safety: 22-36/37
Transport Information:
PSA: 158.26000
LogP: 1.05280
Synthetic route

C31H29N3O7S

26787-78-0

amoxicillin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol; water for 3h;62%
551-16-6

6-Aminopenicillanic Acid

37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

26787-78-0

amoxicillin

Conditions
ConditionsYield
at 30℃; for 3h; Pseudomonas melanogenum KY 3987 and KY 8540; Yield given;
With penicillin acylasefrom Escherichia coli; water
551-16-6

6-Aminopenicillanic Acid

57591-61-4, 68697-60-9, 127369-30-6, 134694-94-3

methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

26787-78-0

amoxicillin

Conditions
ConditionsYield
With iso-butanol In water at 20℃; Xanthomonas citri K24, pH = 6-7; Yield given;
75-21-8

oxirane

cefprozil

26787-78-0

amoxicillin

Conditions
ConditionsYield
In sodium amoxycillin; water; amoxycillin trihydrate; cefaclor monohydrate

ethoxy carbonyl D-α-(1-carbomethoxy-propenyl)amino p-hydroxy phenyl acetate

26787-78-0

amoxicillin

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In acetone
32462-30-9

(S)-hydroxyphenylglycine

3282-30-2

pivaloyl chloride

141-97-9

ethyl acetoacetate

26787-78-0

amoxicillin

Conditions
ConditionsYield
With triethylamine In ethanol; dichloromethane
triethylamine (TEA)

triethylamine (TEA)

82095-48-5, 95510-67-1

D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt

3-trimethylsilyl-2-oxazolidinone (TMSO)

3-trimethylsilyl-2-oxazolidinone (TMSO)

3282-30-2

pivaloyl chloride

26787-78-0

amoxicillin

Conditions
ConditionsYield
In dichloromethane; ISOPROPYLAMIDE; water

A

26787-78-0

amoxicillin

B

760-67-8

2-ethylhexanoic acid chloride

Methoxycarbonyl D-α-(1-carbomethoxypropen-2-yl)amino-p-hydroxyphenyl-acetate

10416-58-7

N,N-bis(trimethylsilyl)acetamide

26787-78-0

amoxicillin

82095-48-5, 95510-67-1

D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt

68698-88-4

N-triisopropylsilyl-2-oxazolidinone

26787-78-0

amoxicillin

Conditions
ConditionsYield
With triethylamine hydrochloride In N-methyl-acetamide; dichloromethane
822-39-9

2-chloro-1,3,2-dioxaphospholan

26787-78-0

amoxicillin

Conditions
ConditionsYield
With chloro-trimethyl-silane; diisopropylamine In dichloromethane

potassium D-α-(1-carbomethoxypropen-2-yl)-amino-p-hydroxyphenylacetate

79-22-1

methyl chloroformate

26787-78-0

amoxicillin

Conditions
ConditionsYield
With chloro-trimethyl-silane; triethylamine In dichloromethane; N,N-dimethyl-formamide
73590-58-6

omeprazole

26787-78-0

amoxicillin

69-65-8

mannitol

A

26787-78-0

amoxicillin

B

clarithromycin

732216-08-9

famotidine

26787-78-0

amoxicillin

551-16-6

6-Aminopenicillanic Acid

D-(-)-4-hydroxyphenylglycineamide

26787-78-0

amoxicillin

Conditions
ConditionsYield
With penicillin acylasefrom Escherichia coli; water
551-16-6

6-Aminopenicillanic Acid

43189-12-4

(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

26787-78-0

amoxicillin

Conditions
ConditionsYield
With penicillin G acylase at 20℃; Enzymatic reaction;

C24H25N3O7S

26787-78-0

amoxicillin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol; water for 3h;
22818-40-2

D-4-hydroxyphenylglycine

26787-78-0

amoxicillin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 8.42 h
2.1: chloroformic acid ethyl ester; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 0 °C
2.2: -60 - 20 °C
3.1: palladium 10% on activated carbon; hydrogen / water; methanol / 3 h
View Scheme
34642-77-8

Acuotricina

A

diketopiperazine

B

26787-78-0

amoxicillin

Conditions
ConditionsYield
With 1,4-dithio-L-threitol In water at 20℃; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
26787-78-0

amoxicillin

109-76-2

Trimethylenediamine

C19H29N5O5S

Conditions
ConditionsYield
With sodium carbonate In water at 0 - 20℃; for 3h; pH=4; Inert atmosphere;100%
646-19-5

heptane-1,7-diamine

26787-78-0

amoxicillin

C23H37N5O5S

Conditions
ConditionsYield
With sodium carbonate In water at 0 - 20℃; for 3h; pH=4; Inert atmosphere;100%
24424-99-5

di-tert-butyl dicarbonate

26787-78-0

amoxicillin

C21H27N3O7S

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃;97%
With potassium carbonate In 1,4-dioxane; water at 0 - 25℃; for 1.5h;
26787-78-0

amoxicillin

C16H21N4O5S(1-)*Na(1+)

Conditions
ConditionsYield
Stage #1: amoxicillin With ammonium hydroxide for 0.333333h;
Stage #2: With sodium hydroxide at 20℃; for 4h;
96%
123-41-1

cholin hydroxide

26787-78-0

amoxicillin

C16H21N4O5S(1-)*C5H14NO(1+)

Conditions
ConditionsYield
Stage #1: amoxicillin With ammonium hydroxide In methanol
Stage #2: cholin hydroxide In methanol at 20℃; for 1h;
93%
951163-09-0

trihexyl(tetradecyl) phosphonium hydroxide

26787-78-0

amoxicillin

C16H21N4O5S(1-)*C32H68P(1+)

Conditions
ConditionsYield
Stage #1: amoxicillin With ammonium hydroxide In methanol
Stage #2: trihexyl(tetradecyl) phosphonium hydroxide In methanol at 20℃; for 1h;
92%
26787-78-0

amoxicillin

34642-77-8

Acuotricina

Conditions
ConditionsYield
Stage #1: amoxicillin With triethylamine In methanol; acetic acid methyl ester at 0 - 5℃;
Stage #2: With sodium 2-ethylhexanoic acid In methanol; acetic acid methyl ester at 0 - 5℃; Product distribution / selectivity;
90%
With sodium hydroxide In water Product distribution / selectivity;
With sodium hydrogencarbonate In water Product distribution / selectivity;
With sodium carbonate In water Product distribution / selectivity;

C5H9N2O3(1-)*K(1+)

26787-78-0

amoxicillin

6-[D-2-(D-2-amino-3-N-methylcarbamoylpropionamido)-2-p-hydroxyphenylacetamido]penicillanic acid

Conditions
ConditionsYield
Stage #1: amoxicillin With trimethylsilyl iodide; triethylamine In dichloromethane at 0℃; for 3h;
Stage #2: C5H9N2O3(1-)*K(1+) With 4-methyl-morpholine; chloroformic acid ethyl ester In dichloromethane at -10 - -5℃; for 15h;
90%
26787-78-0

amoxicillin

105-45-3

acetoacetic acid methyl ester

(Z)-6-(2-(4-hydroxyphenyl)-2-([4-methoxy-4-oxobut-2-en-2-yl]amino)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 6h;86.98%

(R)-1-benzothiazol-2-(4-ethoxy-4-peroxybutanol-2-enyl-2-yl)amino-4-(methylamino)-4-oxothiobutyrate

26787-78-0

amoxicillin

6-[D-2-(D-2-amino-3-N-methylcarbamoylpropionamido)-2-p-hydroxyphenylacetamido]penicillanic acid

Conditions
ConditionsYield
In ethanol; water at -10 - -5℃; for 2.5h; pH=7.5;85.2%
26787-78-0

amoxicillin

[(2,3-bis-methoxycarbonyloxy-benzoyl)-(8-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[8-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-octyl]-amino}-octyl)-amino]-acetic acid

C66H76N6O26S

Conditions
ConditionsYield
Stage #1: [(2,3-bis-methoxycarbonyloxy-benzoyl)-(8-{(2,3-bis-methoxycarbonyloxy-benzoyl)-[8-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-octyl]-amino}-octyl)-amino]-acetic acid With 4-methyl-morpholine; methyl chloroformate In tetrahydrofuran at -10℃; for 1h;
Stage #2: amoxicillin With triethylamine In tetrahydrofuran
83%
26787-78-0

amoxicillin

90-02-8

salicylaldehyde

C23H23N3O6S

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 2h; pH=7 - 8; Reflux;81%
In ethanol for 3h; Inert atmosphere;70%
646-19-5

heptane-1,7-diamine

26787-78-0

amoxicillin

C23H35N5O4S

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 20℃; for 3h; Inert atmosphere;81%
26787-78-0

amoxicillin

477947-79-8

C11H16ClNO4Si

(2R,5R)-3-[2-{[(R)-((2S,5R,6R)-2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-(4-hydroxy-phenyl)-methyl]-amino}-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: amoxicillin With chloro-trimethyl-silane; triethylamine In acetonitrile at 25℃; for 1h;
Stage #2: C11H16ClNO4Si In acetonitrile at 25℃; for 6h;
80%

(8-methoxycarbonyloxy-2,4-dioxobenzoxazin-3-yl)-acetyl chloride

26787-78-0

amoxicillin

N-[(8-methoxycarbonyloxy-2,4-dioxobenzoxazin-3-yl)-acetyl]-amoxicillin

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water; ethyl acetate; Petroleum ether80%
462-94-2

1,5-diaminopentane

26787-78-0

amoxicillin

C21H33N5O5S

Conditions
ConditionsYield
With sodium carbonate In water at 0 - 20℃; for 3h; pH=4; Inert atmosphere;80%
26787-78-0

amoxicillin

77997-18-3

1-hydro-5-(p-aminosulfonyl)anilino-2-hydroxy-oxazolo<5,4-d>pyrimidine

6R-<(R)-2-<3-<2-(p-Aminosulfonyl)anilino-4-hydroxy-5-pyrimidinyl>ureido>-2-(4-hydroxyphenyl)-acetamido>-penicillansaeure, Natriumsalz

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water for 1h;78%
26787-78-0

amoxicillin

501-53-1

benzyl chloroformate

(2S,5R,6R)-3,3-dimethyl-6-[(R)-2-(benzyloxycarbonylamino)-2-(4-benzyloxycarbonyloxyphenyl)acetamido]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: amoxicillin With sodium hydroxide In tetrahydrofuran; water at 20℃; for 0.166667h;
Stage #2: benzyl chloroformate In tetrahydrofuran; water Time; Cooling with ice;
77%
26787-78-0

amoxicillin

1-ethyl-3-methylimidazolium hydroxide

C16H21N4O5S(1-)*C6H11N2(1+)

Conditions
ConditionsYield
Stage #1: amoxicillin With ammonium hydroxide
Stage #2: 1-ethyl-3-methylimidazolium hydroxide In methanol at 20℃; for 1h;
77%
65-22-5

pyridoxal hydrochloride

26787-78-0

amoxicillin

C24H26N4O7S

Conditions
ConditionsYield
With potassium hydroxide In methanol for 0.0416667h; pH=7 - 8; Microwave irradiation;73%
26787-78-0

amoxicillin

137-07-5

2-amino-benzenethiol

C22H22N4O3S2

Conditions
ConditionsYield
With hydrogenchloride In water for 3h; Reflux;70%
26787-78-0

amoxicillin

N-carboxyanhydride of D-4-hydroxyphenylglycine

4-hydroxyphenylglycylamoxicillin

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer In 1,4-dioxane at 0℃; for 1h;69%
26787-78-0

amoxicillin

473988-39-5

3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid N-hydroxysuccinimide ester

α-[(3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxyl)amino-p-hydroxybenzyl]penicillin

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20 - 30℃; for 4h;69%
26787-78-0

amoxicillin

95-54-5

1,2-diamino-benzene

C22H23N5O3S

Conditions
ConditionsYield
With hydrogenchloride In water for 3h; Reflux;68%
141-86-6

2,6-Diaminopyridine

26787-78-0

amoxicillin

C21H24N6O4S

Conditions
ConditionsYield
In ethanol for 3h; Reflux; Inert atmosphere;67%

C14H13NO5

26787-78-0

amoxicillin

C27H26N4O7S

Conditions
ConditionsYield
With triethylamine In water; acetone at -12 - 20℃; for 3.75h;66%
26787-78-0

amoxicillin

473988-44-2

3-(2-chloroethyl)-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid N-hydroxysuccinimide ester

α-[(3-(2-chloroethyl)-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxyl)amino-p-hydroxybenzyl]penicillin

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20 - 30℃; for 4h;65%
26787-78-0

amoxicillin

90-99-3

diphenylchloromethane

477947-68-5

diphenylmethyl 6β-[(R)-2-(diphenylmethylamino)-2-(4-hydroxyphenyl)acetamido]penicillanate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 25℃; for 3h;65%

C15H15NO6

26787-78-0

amoxicillin

C28H28N4O8S

Conditions
ConditionsYield
With triethylamine In water; acetone at -12 - 20℃; for 3.75h;64%
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    Amoxicillin trihydrate

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    26787-78-0 Amoxicillin

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    Amoxicillin

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Chemistry

Structure of Amoxicillin (CAS NO.26787-78-0):

IUPAC Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 
Empirical Formula: C16H19N3O5S
Molecular Weight: 365.4042 
EINECS: 248-003-8 
Index of Refraction: 1.701
Molar Refractivity: 91.47 cm3
Molar Volume: 236.2 cm3
Polarizability: 36.26×10-24cm3
Surface Tension: 85.3 dyne/cm
Density: 1.54 g/cm3
Flash Point: 403.3 °C
Enthalpy of Vaporization: 113.73 kJ/mol
Boiling Point: 743.2 °C at 760 mmHg
Vapour Pressure: 3.39E-23 mmHg at 25°C 
Stability: Stable. Incompatible with strong oxidizing agents. 
Product Categories: Antibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity

Uses

 Amoxicillin can be used as broad-spectrum semi-synthetic PENICILLIN. It is active against gram-positive and -negative bacteri. Clinic for the treatment of tonsillitis, laryngitis, pneumonia, chronic bronchitis, urinary tract infections, skin and soft tissue infections, septic pleurisy, hepatobiliary system infections, sepsis, typhoid, dysentery. The antimicrobial spectrum of goods for drugs, and its role and application of both PENICILLIN and Benzyl chloride similar strengths of the serum protein binding rate and blood concentration more than twice as high as ampicillin.

Production

6-APA and N-(3-ethoxycarbonyl-1-methyl vinyl) Sodium p-hydroxyphenylglycine derived by condensation. 6- APA is the production of a wide range of semi-synthetic PENICILLIN important raw materials. Large industrial use of microorganisms PENICILLIN lactamase cracker natural PENICILLIN (PENICILLIN G or PENICILLIN V) approach to the admission system.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 300mg/kg (300mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Clinical Pediatrics Vol. 32, Pg. 735, 1993.
child TDLo oral 682mg/kg (682mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: HEMATURIA
Clinical Pediatrics Vol. 32, Pg. 735, 1993.
man TDLo oral 7143ug/kg (7.143mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Allergy. Vol. 52(Suppl,
man TDLo oral 40mg/kg/4D (40mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: OTHER CHANGES
Lancet. Vol. 2, Pg. 707, 1978.
mouse LD50 intracrebral > 500mg/kg (500mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Chemotherapy Vol. 26, Pg. 196, 1980.
mouse LD50 intraperitoneal 3590mg/kg (3590mg/kg)   Drugs in Japan Vol. -, Pg. 59, 1990.
mouse LD50 oral > 25gm/kg (25000mg/kg)   Drugs in Japan Vol. 6, Pg. 38, 1982.
mouse LD50 subcutaneous > 20mg/kg (20mg/kg)   Drugs in Japan Vol. -, Pg. 59, 1990.
rat LD50 intraperitoneal 2870mg/kg (2870mg/kg)   Drugs in Japan Vol. -, Pg. 59, 1990.
rat LD50 oral > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. 6, Pg. 38, 1982.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. -, Pg. 59, 1990.

Safety Profile

Hazard Codes : HarmfulXn,IrritantXi
Risk Statements : 42/43 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements : 22-36/37 
S22:Do not breathe dust. 
S36/37:Wear suitable protective clothing and gloves.
WGK Germany : 2
RTECS : XH8300000

Standards and Recommendations

Purity of amoxicillin: 98.00%

Specification

  Amoxicillin , its cas register number is 26787-78-0. It also can be called 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid ; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin ; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid ; Amoclen ; Amolin ; Amopenixin ; Amoxi ; Amoxi-Mast ;Amoxicaps ; Amoxicilina ; Amoxicillin pediatric ; Amoxicilline ; Amoxicillinum Amoxiden ; Amoxil ; Amoxivet ; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin ; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid ; D-Amoxicillin ; Delacillin ; DisperMox ; Hiconcil ; Histocillin ; Ibiamox ; Imacillin ; Larotid ; Metafarma capsules ; Metifarma capsules ; Moxacin ; Moxal ; Wymox ; alpha-Amino-p-hydroxybenzylpenicillin ; p-Hydroxyampicillin .