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| CAS No.: | 26839-75-8 |
|---|---|
| Name: | Timolol |
| Article Data: | 19 |
| Molecular Structure: | |
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|
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| Formula: | C13H24N4O3S |
| Molecular Weight: | 316.425 |
| Synonyms: | 2-Propanol,1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (S)-(-)-(8CI);2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,(S)-;(-)-S-Timolol;(-)-Timolol;(S)-Timolol;Arutimol;L-Timolol;Oftensin;Timolol; |
| EINECS: | 248-032-6 |
| Density: | 1.224 g/cm3 |
| Melting Point: | 71.5 - 72.5oC |
| Boiling Point: | 487.2 °C at 760 mmHg |
| Flash Point: | 248.5 °C |
| Solubility: | slightly sol in water |
| Appearance: | white crystalline powder |
| PSA: | 107.98000 |
| LogP: | 0.95840 |
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Chemistry
Molecular Formula: C13H24N4O3S
Molar mass: 316.42 g/mol
Density: 1.224 g/cm3
Flash Point: 248.5 °C
Index of Refraction: 1.548
Boiling Point: 487.2 °C at 760 mmHg
Vapour Pressure: 2.62E-10 mmHg at 25 °C
Structure of Timolol (CAS NO.26839-75-8):
XLogP3-AA: 1.8
H-Bond Donor: 2
H-Bond Acceptor: 7
IUPAC Name: (2S)-1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Canonical SMILES: CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Isomeric SMILES: CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O
InChI: InChI=1S/C13H24N4O3S/c1-13(2,
3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,
1-3H3/t10-/m0/s1
InChIKey: BLJRIMJGRPQVNF-JTQLQIEISA-N
Uses
In its ophthalmic form (brand names Timoptol in Italy; Timoptic), Timolol (CAS NO.26839-75-8) is used to treat open-angle and occasionally secondary glaucoma by reducing aqueous humour production through blockage of the beta receptors on the ciliary epithelium. In its oral form (Blocadren), it is used to prevent heart attacks and treat high blood pressure , and occasionally to prevent migraine headaches.
Specification
Timolol ,its cas register number is 26839-75-8. It also can be called Timoptol ; Timacar ; Timoptic ; Optimol and Blocadren . Timolol (CAS NO.26839-75-8) is a non-selective beta-adrenergic receptor blocker. The pharmacological mechanism by which it actually does this is still unknown.The most serious possible side effects include severe bronchospasms and cardiac arrhythmias. It also could lead to fainting, congestive heart failure, confusion, depression, impotence and worsening of Raynaud's syndrome.