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| CAS No.: | 26864-56-2 |
|---|---|
| Name: | Penfluridol |
| Molecular Structure: | |
|
|
|
| Formula: | C28H27ClF5NO |
| Molecular Weight: | 523.973 |
| Synonyms: | 4-Piperidinol,1-[4,4-bis(p-fluorophenyl)butyl]-4-(4-chloro-a,a,a-trifluoro-m-tolyl)- (8CI);1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-a,a,a-trifluoro-m-tolyl)-4-piperidinol;McN-JR 16341;Penfluridol;R 16341;Semap; |
| EINECS: | 248-074-5 |
| Density: | 1.29 g/cm3 |
| Melting Point: | 105-107 °C |
| Boiling Point: | 587.7 °C at 760 mmHg |
| Flash Point: | 309.2 °C |
| Solubility: | Insoluble in water |
| Appearance: | white powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 25 |
| Safety: | 45 |
| Transport Information: | UN 2811 |
| PSA: | 23.47000 |
| LogP: | 7.47060 |
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Chemistry
Molecular Formula: C28H27ClF5NO
Molecular Weight; 523.97
EINECS: 248-074-5
Density: 1.29 g/cm3
Storage temp: 2-8°C
Flash Point: 309.2 °C
Solubility: H2O: insoluble
Appearance: white powder
Melting point 105-107 ºC
Index of Refraction: 1.552
Enthalpy of Vaporization: 92.29 kJ/mol
Boiling Point: 587.7 °C at 760 mmHg
Vapour Pressure: 1.17E-14 mmHg at 25°C
Product Categories: API intermediates
IUPAC Name: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-
4-ol
Synonyms 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol
Following is the molecular structure of Penfluridol (26864-56-2):
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Uses
Penfluridol (26864-56-2)is a oral long-acting antipsychotics.It is applicable to all types of mental illness.
Toxicity Data With Reference
| 1. | orl-rat TDLo:3 mg/kg (lactating female 3D post):REP | NSAPCC Naunyn-Schmiedeberg’s Archives of Pharmacology. 279 (1973),31. | ||
| 2. | orl-mus TDLo:48 mg/kg (7-12D preg):TER | OYYAA2 Oyo Yakuri. Pharmacometrics. 13 (1977),581. | ||
| 3. | orl-rat LD50:160 mg/kg | EJPHAZ European Journal of Pharmacology. 11 (1970),139. | ||
| 4. | orl-mus LD50:87 mg/kg | EJPHAZ European Journal of Pharmacology. 11 (1970),139. | ||
| 5. | orl-gpg LD50:90 mg/kg | EJPHAZ European Journal of Pharmacology. 11 (1970),139. |
Safety Profile
Poison by ingestion and intravenous routes. Experimental teratogenic and reproductive effects. A neuroleptic agent. When heated to decomposition it emits very toxic fumes of Cl−, F−, and NOx.
Safety Information of Penfluridol (26864-56-2):
Hazard Codes: T
T: Toxic .gif){kind=small}
Risk Statements: 25
25: Toxic if swallowed
Safety Statements: 45
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TN6957000
Specification
Penfluridol (26864-56-2) is a highly potent, first generation diphenylbutylpiperidine antipsychotic Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dosis is usually 10 — 60 mg.