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27167-53-9

Basic Information
CAS No.: 27167-53-9
Name: Z-D-ALA-OSU
Article Data: 5
Molecular Structure:
Molecular Structure of 27167-53-9 (Z-D-ALA-OSU)
Formula: C15H16 N2 O6
Molecular Weight: 320.302
Synonyms: Carbamicacid, [(1R)-2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl]-, phenylmethylester (9CI); Carbamic acid,[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl]-, phenylmethyl ester,(R)-; Succinimide, N-[(N-carboxy-D-alanyl)oxy]-, benzyl ester (8CI); Alanine,N-carboxy-, N-benzyl ester, succinimido deriv., D- (8CI); D-Alanine,N-[(phenylmethoxy)carbonyl]-, 2,5-pyrrolidinedione deriv.
Density: 1.36
PSA: 102.01000
LogP: 1.23730
Synthetic route
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

26607-51-2

N-benzyloxycarbonyl-D-alanine

27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetonitrile at 0 - 20℃; for 12.5h;85%
With dicyclohexyl-carbodiimide In acetonitrile at -20℃;57%
With dicyclohexyl-carbodiimide In 1,4-dioxane for 12h; Ambient temperature;
74124-79-1

di(succinimido) carbonate

26607-51-2

N-benzyloxycarbonyl-D-alanine

27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0℃; for 1h;
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

13433-00-6

diethyl aminomalonate hydrochloride

130548-14-0

Z-D-Ala-Ama(OEt)-OEt

Conditions
ConditionsYield
With triethylamine In chloroform Ambient temperature;88.9%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

7533-40-6

(S)-2-amino-4-methylpentan-1-ol

177657-04-4

(2S)-2-[N-(Benzyloxycarbonyl-(R)-alanyl)amino]-4-methylpentan-1-ol

Conditions
ConditionsYield
In 1,4-dioxane for 12h; Ambient temperature;88%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

73995-22-9

(S)-4-Amino-4-(ethoxycarbonylmethyl-carbamoyl)-butyric acid tert-butyl ester

126027-24-5

Z-D-Ala-Glu(OBut)-Gly-OEt

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide for 8h; Ambient temperature;76%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

184684-98-8

(S)-2-Amino-3-{4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-propionic acid benzyl ester

184685-00-5

N-(N-benzyloxycarbonyl-D-alanyl)-p-bis(2-hydroxyethyl)amino-L-phenylalanine benzyl ester

Conditions
ConditionsYield
In 1,4-dioxane at 25℃; for 1.5h;73%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

157-06-2

D-arginine

Z-D-Ala-D-Arg-OH hydrochloride

Conditions
ConditionsYield
Stage #1: N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester; D-arginine In water; acetonitrile at 20℃;
Stage #2: With hydrogenchloride In water; acetonitrile pH=2.5;
73%
61-54-1

tryptamine

27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

940290-20-0

N-(benzyloxycarbonyl)-D-alanine tryptamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;71%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

58651-64-2

(S)-(2-amino-4-(tert-butoxy)-4-oxobutanoyl)glycine

126027-23-4

Z-D-Ala-Asp(OBut)-Gly-OH

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide for 8h; Ambient temperature;68%
27167-53-9

N-(benzyloxycarbonyl)-D-alanine N-hydroxysuccinimide ester

66068-76-6

(S)-1-aminoethylphosphonic acid

98820-76-9

[(S)-1-((R)-2-Benzyloxycarbonylamino-propionylamino)-ethyl]-phosphonic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water56%
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  • Z-D-ALA-OSU  CAS NO.27167-53-9

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    Z-D-ALA-OSU CAS NO.27167-53-9

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