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27203-92-5

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Basic Information
CAS No.: 27203-92-5
Name: Tramadol
Article Data: 24
Molecular Structure:
Molecular Structure of 27203-92-5 (Tramadol)
Formula: C16H25NO2
Molecular Weight: 263.38
Synonyms: Cyclohexanol,2-[(dimethylamino)methyl]-1-(m-methoxyphenyl)- (8CI);CG 315E;E 265;Racemic tramadol;Tiparol;Tramadis;Tramadol Contramid;Tramadon;Trapidol;U 26255A;Zytram;cis-Tramadol;
EINECS: 248-319-6
Density: 1.047 g/cm3
Melting Point: 178-181 °C
Boiling Point: 388.1 °C at 760 mmHg
Flash Point: 188.5 °C
Appearance: Light yellow oil
Hazard Symbols: HarmfulXn
Risk Codes: 22
Transport Information: UN 2811 6.1/PG 3
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Chemistry


IUPAC Name: (1R,2R)-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol  
Molecular Formula: C16H25NO2
Molecular Weight: 263.37
EINECS: 248-319-6 
Index of Refraction: 1.532
Molar Refractivity: 77.96 cm3
Molar Volume: 251.3 cm3
Surface Tension: 39.6 dyne/cm 
Density: 1.047 g/cm3 
Flash Point: 188.5 °C 
Enthalpy of Vaporization: 67.22 kJ/mol 
Boiling Point: 388.1 °C at 760 mmHg 
Vapour Pressure: 1.02E-06 mmHg at 25 °C 
Melting point: 178-181 °C
Storage temp:  2-8°C
Appearance: white to off-white solid
Classification Code: Analgesics; Analgesics, opioid; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; Human Data; Narcotics; Peripheral Nervous System Agents; Sensory System Agents

Uses

 Tramadol (CAS NO.27203-92-5) is an analgesic and used in the treatment of urinary incontinence. Tramadol  is a centrally-acting analgesic, used for treating moderate to moderately severe pain. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux, and fibromyalgia. It is used similarly to codeine, to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 4032ug/kg (4.032mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Southern Medical Journal. Vol. 90, Pg. 826, 1997.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   European Patent Application. Vol. #0047990,
rat LD50 oral 228mg/kg (228mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 286mg/kg (286mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
women TDLo oral 16mg/kg/4D-I (16mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: EUPHORIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
American Journal of Psychiatry. Vol. 154, Pg. 1624, 1997.


 

Safety Profile

Hazard Codes  HarmfulXn
Risk Statements:  22
R22:Harmful if swallowed.
RIDADR:  UN 2811 6.1/PG 3
WGK Germany:  2

Specification

 Tramadol (CAS NO.27203-92-5), its Synonyms are Cyclohexanol, 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)- ; Ralivia ER ; Ralivia flashtab ; Tradonal odis ; Ultram ; Cyclohexanol, 2-((dimethylamino)-1-(3-methoxyphenyl)-, cis-(+-)- ; Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)- .