Products Categories
CAS No.: | 272778-12-8 |
---|---|
Name: | 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone |
Molecular Structure: | |
|
|
Formula: | C39H46F2N2O5Si2 |
Molecular Weight: | 716.972 |
Synonyms: | 2-Oxazolidinone,3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-,(4S)-; |
EINECS: | 1592732-453-0 |
Density: | 1.177 g/cm3 |
Boiling Point: | 748.9 °C at 760 mmHg |
Flash Point: | 406.7 °C |
PSA: | 77.10000 |
LogP: | 10.05190 |
chloro-trimethyl-silane
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - 0℃; Inert atmosphere; Stage #2: With titanium tetrachloride In dichloromethane at -30 - -25℃; Inert atmosphere; | 66.6% |
With triethylamine In dichloromethane at -20℃; Reagent/catalyst; Solvent; |
chloro-trimethyl-silane
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (E)-(4-hydroxy-benzylidene)-(4-fluorophenyl)-amine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - -5℃; Stage #2: chloro-trimethyl-silane In dichloromethane at -5℃; for 1.5h; Stage #3: With titanium tetrachloride In dichloromethane at -30 - -25℃; for 3h; | 65% |
chloro-trimethyl-silane
N,O-bis-(trimethylsilyl)-acetamide
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - -5℃; for 1h; Stage #2: With titanium tetrachloride In dichloromethane at -30℃; for 20h; Stage #3: N,O-bis-(trimethylsilyl)-acetamide | 60% |
(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tetrabutylammonium acetate In tert-butyl methyl ether at 20℃; for 0.25h; Product distribution / selectivity; | |
With N,O-bis-(trimethylsilyl)-acetamide; potassium acetate In tetrahydrofuran at 20 - 60℃; for 5.5h; Product distribution / selectivity; | |
Stage #1: (4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one With N,O-bis-(trimethylsilyl)-acetamide; potassium acetate In tetrahydrofuran at 20℃; for 0.5h; Stage #2: With tetrabutylammomium bromide In tetrahydrofuran at 20℃; for 0.7h; Product distribution / selectivity; |
(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
ezetemibe
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride In toluene at 28℃; for 2.66667h; Temperature; Inert atmosphere; Large scale; |
What can I do for you?
Get Best Price
Product Name: 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
Molecular Structure of 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone (CAS NO.272778-12-8):
Molecular Formula: C39H48F2N2O4Si2
Molecular Weight: 702.98
CAS NO: 272778-12-8
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 15
Polar Surface Area: 60.03 Å2
Index of Refraction: 1.558
Molar Refractivity: 198.56 cm3
Molar Volume: 615 cm3
Surface Tension: 39.5 dyne/cm
Density: 1.143 g/cm3
Flash Point: 405.7 °C
Enthalpy of Vaporization: 108.92 kJ/mol
Boiling Point: 747.2 °C at 760 mmHg
Vapour Pressure: 3.35E-22 mmHg at 25°C
Synonyms of 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone (CAS NO.272778-12-8): 2-Oxazolidinone, 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(s)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-, (4S)-
SMILES: C[Si](C)(C)Oc1ccc(cc1)[C@H]([C@@H](CC[C@@H](c2ccc(cc2)F)O[Si](C)(C)C)CN3[C@H](COC3=O)c4ccccc4)Nc5ccc(cc5)F
InChI: InChI=1/C39H48F2N2O4Si2/c1-48(2,3)46-35-23-14-30(15-24-35)38(42-34-21-19-33(41)20-22-34)31(26-43-36(27-45-39(43)44)28-10-8-7-9-11-28)16-25-37(47-49(4,5)6)29-12-17-32(40)18-13-29/h7-15,17-24,31,36-38,42H,16,25-27H2,1-6H3/t31-,36+,37-,38+/m0/s1
InChIKey: IUUHLCBMXXGIDB-AUUUEPFHBQ
Std. InChI: InChI=1S/C39H48F2N2O4Si2/c1-48(2,3)46-35-23-14-30(15-24-35)38(42-34-21-19-33(41)20-22-34)31(26-43-36(27-45-39(43)44)28-10-8-7-9-11-28)16-25-37(47-49(4,5)6)29-12-17-32(40)18-13-29/h7-15,17-24,31,36-38,42H,16,25-27H2,1-6H3/t31-,36+,37-,38+/m0/s1
Std. InChIKey: IUUHLCBMXXGIDB-AUUUEPFHSA-N