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28020-38-4

Basic Information
CAS No.: 28020-38-4
Name: 2,3-Diamino-6-methoxypyridine
Article Data: 21
Molecular Structure:
Molecular Structure of 28020-38-4 (2,3-Diamino-6-methoxypyridine)
Formula: C6H9N3O
Molecular Weight: 139.157
Synonyms: Pyridine,2,3-diamino-6-methoxy- (8CI);6-(Methyloxy)-2,3-pyridinediamine;6-Methoxy-2,3-diaminopyridine;6-Methoxypyridine-2,3-diamine;
EINECS: 207-166-5
Density: 1.251 g/cm3
Melting Point: 168-170 °C
Boiling Point: 321.7 °C at 760 mmHg
Flash Point: 148.3 °C
Hazard Symbols: IrritantXi
Risk Codes: 20/21/22-36/37/38
Safety: 26-36/37/39-36
PSA: 74.16000
LogP: 3.02100
Synthetic route
73896-36-3

6-methoxy-3-nitropyridin-2-amine

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 16h;100%
With hydrogen; palladium 10% on activated carbon at 25℃; for 6h;99%
With hydrogen; palladium on activated charcoal In ethanol under 760 Torr;

6-methoxypyridine-2,3-diamine dihydrochloride

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
With ammonia In water at 15℃; pH=7 - 8;92%
27048-04-0

2-amino-6-chloro-3-nitropyridine

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / NaOMe / 2 h / Heating
2: H2 / 10percent Pd/C / ethanol / 760 Torr
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 16 h / -15 - 20 °C
2: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C
View Scheme
16013-85-7

2,6-dicholoro-3-nitropyridine

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonium hydroxide / 5 h / 50 °C
2: ethanol / 16 h / -15 - 20 °C
3: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C
View Scheme
2402-78-0

2,6-dichloropyridine

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / -15 - 150 °C
2: ammonium hydroxide / 5 h / 50 °C
3: ethanol / 16 h / -15 - 20 °C
4: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C
View Scheme
38533-61-8

2-chloro-6-methoxy-3-nitropyridine

28020-38-4

2,3-diamino-6-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / methanol / 18 h / 65 °C
2: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 2 steps
1: ammonia; ammonium hydroxide / methanol / 18 h / 65 °C
2: hydrogen; palladium on activated charcoal / ethanol / 760.05 Torr
View Scheme
28020-38-4

2,3-diamino-6-methoxypyridine

105-07-7

4-cyanobenzaldehyde

2-(4-cyanophenyl)-5-methoxy-4-azabenzimidazole

Conditions
ConditionsYield
With sodium metabisulfite; dimethyl sulfoxide at 165℃; for 0.25h; Inert atmosphere; Sealed tube;92%

5-(3,4,5-trimethoxybenzoyl)-1H-indole-3-carbaldehyde

28020-38-4

2,3-diamino-6-methoxypyridine

(3-(5-cethoxy-3H-imidazo[4,5-b]pyridin-2-yl)-1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone

Conditions
ConditionsYield
With sodium metabisulfite In ethanol; water at 80℃; for 2h;85%
28020-38-4

2,3-diamino-6-methoxypyridine

501-53-1

benzyl chloroformate

1040363-61-8

benzyl 2-amino-6-methoxypyridin-3-ylcarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;83%
64-18-6

formic acid

28020-38-4

2,3-diamino-6-methoxypyridine

5-methoxy-1H-imidazo[4,5-b]pyridine

Conditions
ConditionsYield
at 105℃; for 8h;78.6%
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    2,3-Pyridinediamine,6-methoxy-

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  • 6-Methoxypyridine-2,3-diamine

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Chemistry

Following is the structure of 2,3-Pyridinediamine,6-methoxy- (CAS NO.28020-38-4):
                             
Empirical Formula: C6H9N3O
Molecular Weight: 139.1552 g/mol
Molar Refractivity: 39.49 cm3
Molar Volume: 111.2 cm3
Density: 1.251 g/cm3
Flash Point: 148.3 °C
Melting point: 168-170 °C
Index of Refraction: 1.628
Surface Tension: 60.1 dyne/cm
Enthalpy of Vaporization: 56.34 kJ/mol
Boiling Point: 321.7 °C at 760 mmHg
Vapour Pressure of 2,3-Pyridinediamine,6-methoxy- (CAS NO.28020-38-4): 0.000294 mmHg at 25 °C
Product Categories of 2,3-Pyridinediamine,6-methoxy- (CAS NO.28020-38-4): Pyridines derivates;Pyridine
SMILES: O(c1nc(c(N)cc1)N)C
InChI: InChI=1/C6H9N3O/c1-10-5-3-2-4(7)6(8)9-5/h2-3H,7H2,1H3,(H2,8,9)
InChIKey: WEPOCTWSRWLQLL-UHFFFAOYAT

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 20/21/22-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S36:Wear suitable protective clothing.

Specification

 2,3-Pyridinediamine,6-methoxy- , its cas register number is 28020-38-4. It also can be called 2,3-Diamino-6-methoxypyridine ; 6-Methoxy-2,3-Diaminopyridine ; 6-Methoxy-2,3-pyridinediamine ;6-Methoxypyridin-2,3-diamin ; and 6-Methoxypyridine-2,3-diamine .