CAS No.28143-91-1,(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	28143-91-1
Name:	(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol
Article Data:	45

Formula:	C₉H₁₃NO₂
Molecular Weight:	167.208
Synonyms:	1,3-Propanediol,2-amino-1-phenyl-, L-threo-(+)- (8CI);1,3-Propanediol, 2-amino-1-phenyl-,[S-(R,R)]-;(1S,2S)-(+)-1-Phenyl-2-amino-1,3-propanediol;(1S,2S)-2-Amino-1-phenyl-1,3-propanediol;(2S,3S)-3-Phenylpropane-2-amine-1,3-diol;(S,S)-2-Amino-1-phenyl-1,3-propanediol;L-(+)-threo-1-Phenyl-2-amino-1,3-propanediol;
EINECS:	248-867-6
Density:	1.206 g/cm³
Melting Point:	110 °C
Boiling Point:	360.6 °C at 760 mmHg
Flash Point:	171.9 °C
Appearance:	white to light yellow crystal powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-37/39
PSA:	66.48000
LogP:	0.73990

Synthetic route

: 119677-35-9
(2R,3S)-2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 3306-06-7, 5285-86-9, 28143-91-1, 36391-67-0, 36391-68-1, 46032-98-8, 55057-81-3, 105452-39-9, 119364-52-2
(+/-)-threo-2-amino-1-phenyl-1,3-propanediol

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

Conditions

Conditions	Yield
With L-Tartaric acid
With L-(-)-O,O'-dibenzoyltartaric acid
With (1S)-(+)-3-bromocamphor-10-sulfonic acid
With D-Glutamic acid

: 91247-54-0
1-Phenyl-2-acetamido-1,3-propandiol

A: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

B: 46032-98-8
(1R,2R)-2-amino-1-phenylpropane-1,3-diol

C: 105452-39-9
(1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol

D: 119364-52-2
(1S,2R)-2-amino-1-phenylpropane-1,3-diol

Conditions

Conditions	Yield
hydrolysis;

...Expand

: 125219-10-5
((1S,2S)-2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester

A: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Irradiation; mild conditions;

(1S,2S)-2-amino-1-<4-amino-phenyl>-propane-1,3-diol: (1S,2S)-2-amino-1-<4-amino-phenyl>-propane-1,3-diol

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

Conditions

Conditions	Yield
With hypophosphorous acid; sodium nitrite

(5S)-2,2-dimethyl-4c-phenyl-<1,3>dioxan-5r-ylamine: (5S)-2,2-dimethyl-4c-phenyl-<1,3>dioxan-5r-ylamine

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

Conditions

Conditions	Yield
With mineral acid

(+-)-2,2-dimethyl-4c-phenyl-<1,3>dioxan-5r-ylamine: (+-)-2,2-dimethyl-4c-phenyl-<1,3>dioxan-5r-ylamine

A: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

B: 46032-98-8
(1R,2R)-2-amino-1-phenylpropane-1,3-diol

Conditions

Conditions	Yield
With (1S)-(+)-3-bromocamphor-10-sulfonic acid; ethyl acetate

: 167082-56-6
tert-butyl [(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]carbamate

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 4h;

: 50-00-0
formaldehyd

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: C30H39N3O6

Conditions

Conditions	Yield
In methanol at 20℃; for 16h;	100%

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 501-53-1
benzyl chloroformate

: 127102-27-6
benzyl L-threo-1,3-dihydroxy-1-phenylpropan-2-yl-carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water Ambient temperature;	99%
With triethylamine In methanol for 1h; Ambient temperature;	91%

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Chemistry

IUPAC Name: 2-amino-1-phenylpropane-1,3-diol
The MF of (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol(28143-91-1): C₉H₁₃NO₂
The MW of (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol(28143-91-1): 167.21
EINECS: 248-867-6
mp: 110 °C
alpha: 35 °(c=1, 1N HCl)
refractive index: 26.5 ° (C=1, MeOH)
Molar Refractivity: 47 cm³
Molar Volume: 138.5 cm³
Polarizability: 18.63 10^-24 cm³
Surface Tension: 57.8 dyne/cm
Density: 1.206 g/cm³
Flash Point: 171.9 °C
Enthalpy of Vaporization: 63.98 kJ/mol
Boiling Point: 360.6 °C at 760 mmHg
Vapour Pressure: 7.87E-06 mmHg at 25°C
Appearance: white to light yellow crystal powder
Categories: Propanes/propenes;chiral;Amino Alcohols (Chiral);Chiral Building Blocks;Asymmetric Synthesis;for Resolution of Acids;Optical Resolution;Synthetic Organic Chemistry
Synonyms: S-BASE;LBS;Levo-Amin-odiol;threo-2-amino-1-phenyl-1,3-propanediol;L(+)-THREO-2-AMINO-1-PHENYL-1,1,3-PROPANEDIOL;L-(+)-THREO-2-AMINO-1-PHENYL-1,3-PROPANEDIOL;L-THREO-(+)-PHENYL-2-AMINO-1,3-PROPANDIOL;L-(+)-THREO-1-PHENYL-2-AMINO-1,3-PROPANEDIOL
The Structure of (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol(28143-91-1):

Uses

(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol(28143-91-1) is used as pharmaceutical intermediates.
(1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol(28143-91-1) is used in pharmaceutical industry.

Safety Profile

Hazard Codes:

Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3

Specification

1. First Aid Measures
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
2. Handling and Storage
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.