CAS No.28395-03-1,Bumetanide Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	28395-03-1
Name:	Bumetanide

Formula:	C₁₇H₂₀N₂O₅S
Molecular Weight:	364.422
Synonyms:	Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI);3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid;Bumex;Burinex;Fontego;Fordiuran;Lixil;Lunetoron;PF1593;Ro 10-6338;
EINECS:	249-004-6
Density:	1.347 g/cm³
Melting Point:	230-231 °C
Boiling Point:	571.2 °C at 760 mmHg
Flash Point:	299.3 °C
Solubility:	Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml).
Appearance:	crystalline solid
PSA:	127.10000
LogP:	4.89060

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Chemistry

Molecular Structure of Bumetanide (CAS NO.28395-03-1):

IUPAC Name: 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Molecular Formula: C₁₇H₂₀N₂O₅S
Molecular Weight: 364.416100 g/mol
EINECS: 249-004-6
Melting Point: 230-231 °C
Density: 1.347 g/cm³
Flash Point: 299.3 °C
Enthalpy of Vaporization: 90.11 kJ/mol
Boiling Point: 571.2 °C at 760 mmHg
Vapour Pressure: 6.89E-14 mmHg at 25 °C
Water Solubility: 32.22 mg/L at 25 °C
Appearance: Crystalline Solid
Classification Code: Diuretic; Diuretics; Drug / Therapeutic Agent; Membrane Transport Modulators; Natriuretic Agents; Sodium Potassium Chloride Symporter Inhibitors

Uses

Bumetanide (CAS NO.28395-03-1) is used to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective with the brand name Bumex.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	> 500ug/kg (0.5mg/kg)	BEHAVIORAL: TETANY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972.
dog	LDLo	oral	> 500ug/kg (0.5mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972.
mammal (species unspecified)	LD50	intravenous	6200ug/kg (6.2mg/kg)		Journal of Clinical Pharmacology. Vol. 21, Pg. 543, 1981.
mouse	LD50	intramuscular	> 25mg/kg (25mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976.
mouse	LD50	intraperitoneal	519mg/kg (519mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
mouse	LD50	intravenous	> 200mg/kg (200mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
mouse	LD50	oral	4624mg/kg (4624mg/kg)		Drugs in Japan Vol. 6, Pg. 683, 1982.
mouse	LD50	subcutaneous	1660mg/kg (1660mg/kg)		Drugs in Japan Vol. 6, Pg. 683, 1982.
rabbit	LD50	intravenous	70mg/kg (70mg/kg)		Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
rabbit	LD50	oral	350mg/kg (350mg/kg)		Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
rat	LD50	intramuscular	> 5mg/kg (5mg/kg)		Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976.
rat	LD50	intraperitoneal	891mg/kg (891mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
rat	LD50	intravenous	> 200mg/kg (200mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
rat	LD50	oral	> 6gm/kg (6000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
Safety Information of Bumetanide (CAS NO.28395-03-1):
WGK Germany: 3
RTECS: DG4910000

Specification

Bumetanide (CAS NO.28395-03-1), its Synonyms are Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI) ; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid ; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid ; 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid ; Bufenox ; Bumex ; Burinex ; Edemex ; Fontego ; Fordiuran ; Lixil ; Lunetoron .