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| CAS No.: | 28911-01-5 |
|---|---|
| Name: | Triazolam |
| Article Data: | 19 |
| Molecular Structure: | |
|
|
|
| Formula: | C17H12 Cl2 N4 |
| Molecular Weight: | 343.215 |
| Synonyms: | 4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-(o-chlorophenyl)-1-methyl- (8CI);8-Chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine; DII-18-2; Halcion; Novodorm; Songar; Triazolam; U 33030 |
| EINECS: | 249-307-3 |
| Density: | 1.46 g/cm3 |
| Melting Point: | 209-212°C |
| Boiling Point: | 535.6 °C at 760 mmHg |
| Flash Point: | 277.7 °C |
| Solubility: | soluble in alcohol and poorly soluble in water. |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 T F
|
| Risk Codes: | 11-23/24/25-36/38-39/23/24/25 |
| Safety: | 22-24/25-26-36-45-36/37-16-7 |
| PSA: | 43.07000 |
| LogP: | 3.66910 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
IUPAC Name: 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (28911-01-5)
Synonyms : 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Structure: 
Molecular Formula : C17H12Cl2N4
Molecular Weight : 343.21
CAS Registry Number : 28911-01-5
EINECS: 249-307-3
Mol File: 28911-01-5.mol
Surface Tension: 53.4 dyne/cm
Density: 1.46 g/cm3
Flash Point: 277.7 °C
Storage temp: 2-8°C
Enthalpy of Vaporization: 81.21 kJ/mol
Boiling Point: 535.6 °C at 760 mmHg
Vapour Pressure: 1.51E-11 mmHg at 25°C
Uses
Triazolam (28911-01-5) sedative, hypnotic.,controlled Substance.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 7ug/kg (0.007mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: SLEEP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Journal of Clinical Pharmacology. Vol. 14, Pg. 102, 1974. |
| human | TDLo | oral | 29ug/kg (0.029mg/kg) | BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996. |
| human | TDLo | oral | 114ug/kg/4D-I (0.114mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | British Medical Journal. Vol. 304, Pg. 1178, 1992. |
| man | TDLo | oral | 1786ng/kg (0.001786mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Southern Medical Journal. Vol. 80, Pg. 1425, 1987. |
| man | TDLo | oral | 3289ng/kg (0.003289mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING | Clinical Pharmacology and Therapeutics Vol. 49, Pg. 581, 1991. |
| man | TDLo | oral | 7ug/kg (0.007mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION | Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 185, 1995. |
| man | TDLo | oral | 100ug/kg (0.1mg/kg) | BEHAVIORAL: SLEEP BEHAVIORAL: ATAXIA CARDIAC: PULSE RATE | Journal of Clinical Psychiatry. Vol. 47, Pg. 50, 1986. |
| man | TDLo | oral | 107ug/kg (0.107mg/kg) | BEHAVIORAL: COMA | Archives of Internal Medicine. Vol. 145, Pg. 663, 1985. |
| man | TDLo | oral | 357ug/kg (0.357mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: IRRITABILITY BEHAVIORAL: COMA | Human & Experimental Toxicology. Vol. 11, Pg. 289, 1992. |
| mouse | LD50 | intraperitoneal | 1625mg/kg (1625mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983. | |
| mouse | LD50 | oral | 1080mg/kg (1080mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" | Cesko-Slovenska Farmacie. Vol. 37, Pg. 443, 1988. |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 499, 1983. | |
| rat | LD50 | intraperitoneal | > 3300mg/kg (3300mg/kg) | Drugs in Japan Vol. -, Pg. 860, 1995. | |
| rat | LD50 | oral | > 7500mg/kg (7500mg/kg) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1074, 1984. | |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 499, 1983. | |
| women | TDLo | oral | 100ug/kg (0.1mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | American Journal of Emergency Medicine. Vol. 3, Pg. 210, 1985. |
Safety Profile
Hazard Codes F.gif){kind=small}
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Risk Statements 11-36/38-39/23/24/25
11: Triazolam (28911-01-5) is highly Flammable.
36/38: Irritating to eyes and skin
39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements 22-24/25-26-45-36/37-16-7
7: Keep container tightly closed
16: Keep Triazolam (28911-01-5) away from sources of ignition - No smoking
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
36/37: Wear suitable protective clothing and gloves
RIDADR 3249
WGK Germany 2
RTECS XZ5472500
HazardClass 6.1(b)
PackingGroup III