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| CAS No.: | 2955-38-6 |
|---|---|
| Name: | PRAZEPAM |
| Article Data: | 12 |
| Molecular Structure: | |
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|
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| Formula: | C19H17 Cl N2 O |
| Molecular Weight: | 324.81 |
| Synonyms: | 1-(Cyclopropylmethyl)-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one;1-Cyclopropylmethyl-5-phenyl-7-chloro-1H-1,4-benzodiazepin-2(3H)-one;7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;Centrax; Demetrin; K 373; Lysanxia; NSC 277179; Prazene; Prazepam; Sedapran;Settima; Trepidan; Verstran; W 4020 |
| Density: | 1.31g/cm3 |
| Melting Point: | 145-146° |
| Boiling Point: | 538.5°Cat760mmHg |
| Flash Point: | 279.5°C |
| Solubility: | 9.095mg/L(25 oC) |
| Hazard Symbols: |
 
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| Risk Codes: | 11-23/24/25-39/23/24/25 |
| Safety: | Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). A tranquilizer and muscle relaxant. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
| PSA: | 32.67000 |
| LogP: | 3.43460 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Product Name: Demetrin (CAS NO.2955-38-6)
Molecular Formula: C19H17ClN2O
Molecular Weight: 324.8g/mol
Mol File: 2955-38-6.mol
Einecs: 220-975-8
Boiling point: 538.5 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 279.5 °C
Density: 1.31 g/cm3
Surface Tension: 50.5 dyne/cm
Enthalpy of Vaporization: 81.56 kJ/mol
Vapour Pressure: 1.15E-11 mmHg at 25°C
XLogP3: 3.6
H-Bond Donor: 0
H-Bond Acceptor: 2
Product Categories: Benzodiazepines and Anxiolytics; Neurobiology; Pharmacologicals
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 4gm/kg (4000mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 759, 1978. |
| mouse | LD50 | intraperitoneal | 1020mg/kg (1020mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978. |
| mouse | LD50 | oral | 2300mg/kg (2300mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #79-92631, | |
| mouse | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978. |
| rat | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978. |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978. |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978. |
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985). A tranquilizer and muscle relaxant. When heated to decomposition it emits toxic fumes of Cl− and NOx.
Safety Information of Demetrin (CAS NO.2955-38-6):
Hazard Codes: F.gif){kind=small}
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Risk Statements: 11-23/24/25-39/23/24/25
11: Highly Flammable
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
39: Danger of very serious irreversible effects
Safety Statements: 22-24/25-45-36/37-16
16: Keep away from sources of ignition - No smoking
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Specification
Demetrin ,its CAS NO. is 2955-38-6,the synonyms is 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl- ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl- ; 2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl ; 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-o ; 7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one ; 7-Chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one ; 7-Chloro-1-cyclopropylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one ; Centrax .