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CAS No.: | 29632-74-4 |
---|---|
Name: | 2-Fluoro-4-iodoaniline |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C6H5FIN |
Molecular Weight: | 237.015 |
Synonyms: | 2-fluoro-4-iodin anline; |
Density: | 2.008 g/cm3 |
Melting Point: | 55-57 °C(lit.) |
Boiling Point: | 248.6 °C at 760 mmHg |
Flash Point: | 104.2 °C |
Solubility: | insoluble in water |
Appearance: | off-white to brown powder |
Hazard Symbols: | Xn, T, Xi |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-36-37/39-26/37/39 |
PSA: | 26.02000 |
LogP: | 2.59370 |
2-Fluoroaniline
2-fluro-4-iodoaniline
Conditions | Yield |
---|---|
With iodine; sodium hydrogencarbonate In water at 60 - 80℃; for 2h; | 77% |
With iodine; sodium hydrogencarbonate In water at 60℃; for 3h; | 76% |
Stage #1: 2-Fluoroaniline With n-butyllithium In diethyl ether; hexane at -78℃; for 1h; Stage #2: With poly[4-(dibutyliodostannyl)butyl]styrene In diethyl ether; hexane at 20℃; for 18h; Stage #3: With Iodine monochloride In diethyl ether; hexane at -78 - 20℃; | 67% |
2-fluro-4-iodoaniline
trimethylsilylacetylene
2-fluoro-4-((trimethylsilyl)ethynyl)aniline
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 21h; Sonogashira Cross-Coupling; Inert atmosphere; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Inert atmosphere; | 100% |
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 20℃; for 15h; Sonogashira Coupling; | 88% |
4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid
2-fluro-4-iodoaniline
4-(2-fluoro-4-iodophenylamino)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity; | 100% |
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4.08333h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity; | 100% |
Stage #1: 4-chloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid; 2-fluro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 4.08333h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity; | 100% |
thiophosgene
2-fluro-4-iodoaniline
2-fluoro-4-iodo-1-isothiocyanatobenzene
Conditions | Yield |
---|---|
In chloroform; water at 20℃; for 16h; | 100% |
In chloroform; water at 20℃; for 16h; | 100% |
In dichloromethane; water at 20℃; | 96.8% |
Conditions | Yield |
---|---|
With acetic anhydride In tetrahydrofuran; toluene at 20℃; | 100% |
2-fluro-4-iodoaniline
sodium O-ethyl dithiocarbonate
6-iodobenzo[d]thiazole-2-thiol
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 95℃; for 5h; | 100% |
2-fluro-4-iodoaniline
2,3,4,-trifluorobenzoic acid
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid
Conditions | Yield |
---|---|
With lithium amide In tetrahydrofuran | 99% |
With lithium amide In N,N-dimethyl-formamide Inert atmosphere; | 85% |
With lithium amide In tetrahydrofuran at 45 - 55℃; for 1.25 - 2.5h; Product distribution / selectivity; | 80% |
2-fluro-4-iodoaniline
1-azido-2-fluoro-4-iodobenzene
Conditions | Yield |
---|---|
Stage #1: 2-fluro-4-iodoaniline With trifluoroacetic acid; sodium nitrite at 0℃; for 0.5h; Stage #2: With sodium azide In water at 0℃; for 1h; | 99% |
Stage #1: 2-fluro-4-iodoaniline With hydrogenchloride; sodium nitrite In water at -5℃; for 0.5h; Stage #2: With sodium azide In water at -5℃; for 1h; | 97% |
Conditions | Yield |
---|---|
With N,N`-dimethylethylenediamine; copper (I) trifluoromethane sulfonate benzene In dimethyl sulfoxide at 120℃; for 16h; | 99% |
copper(I) trifluoromethanesulfonate benzene complex; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 120℃; for 16h; | 99% |
With N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene In dimethyl sulfoxide at 120℃; for 16h; | 99% |
2-fluro-4-iodoaniline
cyclopropanecarboxylic acid chloride
N-(2-fluoro-4-iodophenyl)cyclopropanecarboxamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; | 99% |
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