CAS No.300-54-9,(+/-)-MUSCARINE CHLORIDE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	300-54-9
Name:	(+/-)-MUSCARINE CHLORIDE

Formula:	C9H20 N O2
Molecular Weight:	174.30
Synonyms:	2-Furanmethanaminium,tetrahydro-4-hydroxy-N,N,N,5-tetramethyl-, [2S-(2a,4b,5a)]-; Muscarine (alkaloid) (8CI);(+)-(2S,4R,5S)-Muscarine; (+)-Muscarine; L-(+)-Muscarine; Muscarine; [2S-(2a,4b,5a)]-(Tetrahydro-4-hydroxy-5-methylfurfuryl)trimethylammonium
Density:	g/cm³
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Hazard Symbols:
Risk Codes:	22-36
Safety:	Human poison by an unspecified route. Experimental poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x and NH₃.
PSA:	29.46000
LogP:	0.23090

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Chemistry

The IUPAC name of Muscarine (CAS NO.300-54-9):
[(2S,4R,5S)-4-Hydroxy-5-methyloxolan-2-yl]methyltri-methylazanium
Synonyms: Muscarin;muscarine(thealkaloid) ; Trimethyl(tetrahydro-4-hydroxy-5-methylfurfuryl)-ammoniu ; [2S-(2Alpha,4beta,5alpha)]-[tetrahydro-4-hydroxy-5-methylfurfuryl]trimethylammonium ; (+)-L-Muscarine ; (2S)-Tetrahydro-4β-hydroxy-N,N,N,5α-tetramethyl-2α-furanmethanaminium ; (2S,4R,5S)-Tetrahydro-4-hydroxy-5,N,N,N-tetramethyl-2-furanmethanaminium
CAS: 300-54-9
EINECS: 206-094-1
Molecular Formula: C₉H₂₀NO2
Molecular Structure:

Molecular Weight: 174.2601 g/mol

History

Muscarine, L-(+)-muscarine, or muscarin is a natural product found in certain mushrooms, particularly in Inocybe and Clitocybe species, such as the deadly C. dealbata. It was first isolated from Amanita muscaria in 1869. It was the first parasympathomimetic substance ever studied and causes profound activation of the peripheral parasympathetic nervous system that may end in convulsions and death. Being a quaternary amine, Muscarine is less completely absorbed from the gastrointestinal tract than tertiary amines, but it does cross the blood brain barrier

Toxicity Data With Reference

The toxicity of Muscarine (CAS NO.300-54-9):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	1100ug/kg (1.1mg/kg)		Science. Vol. 144, Pg. 1100, 1964. Link to PubMed
cat	LDLo	oral	7mg/kg (7mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
cat	LDLo	subcutaneous	2mg/kg (2mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 406, 1948.
frog	LDLo	parenteral	160ug/kg (0.16mg/kg)		Justus Leibigs Annalen der Chemie. Vol. 489, Pg. 156, 1931.
frog	LDLo	unreported	160ug/kg (0.16mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 407, 1948.
man	LDLo	unreported	735ug/kg (0.735mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD₅₀	intraperitoneal	5mg/kg (5mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971.
mouse	LD₅₀	intravenous	230ug/kg (0.23mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toxicology Letters. Vol. 1000(Sp,
mouse	LD₅₀	subcutaneous	1100ug/kg (1.1mg/kg)		Naturwissenschaften. Vol. 56, Pg. 615, 1969.
mouse	LDLo	oral	750mg/kg (750mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 167, 1973.
rabbit	LDLo	oral	150mg/kg (150mg/kg)	VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.
rabbit	LDLo	subcutaneous	27mg/kg (27mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.

Safety Profile

The Hazard Codes of Muscarine (CAS NO.300-54-9): Harmful Xn
Risk Statements:R22:Harmful if swallowed. R36:Irritating to eyes.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Human poison by an unspecified route. Experimental poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x and NH₃.