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Basic Information
CAS No.: 301-04-2
Name: LEAD ACETATE
Article Data: 54
Molecular Structure:
Molecular Structure of 301-04-2 (LEAD ACETATE)
Formula: C2H4O2.1/2Pb
Molecular Weight: 325.289
Synonyms: Acetate de plomb;Acetic acid lead(2+) salt;Acetic acid, lead salt;Bleiacetat;CCRIS 356;Caswell No. 523A;Dibasic lead acetate;HSDB 1404;Lead acetate (Pb(Ac)2);Normal lead acetate;Plumbous acetate;Salt of saturn;
EINECS: 206-104-4
Density: 1.068g/cm3
Melting Point: 75 °C (dec.)(lit.)
Boiling Point: 117.1oC at 760 mmHg
Flash Point: 40oC
Solubility: g/100g H2O: 19.7 (0°C), 55.2 (25°C); equilibrium solid phase, Pb(CH3COO)2 ·3H2O [KRU93]; g/100mL H2O: 44.3 (20°C), 221 (50°C) [KIR78]
Hazard Symbols: ToxicT, DangerousN
Risk Codes: 61-33-48/22-50/53-62
Safety: 53-45-60-61
Transport Information: UN 1616 6.1/PG 3
PSA: 37.30000
LogP: -0.06490
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Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 230.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 23 , 1980,p. 325.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 , 1972,p. 40.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 23 , 1980,p. 325.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Lead and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Standards and Recommendations

OSHA PEL: TWA 0.05 mg(Pb)/m3
ACGIH TLV: TWA 0.15 mg(Pb)/m3
NIOSH REL: (Inorganic Lead) TWA 0.10 mg(Pb)/m3
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD

Specification

The Lead acetate, also known as Acetic acid, lead(2 +) salt, is an organic compound with the formula C2H4O2.1/2Pb. This chemical is a white crystalline chemical compound with a sweetish taste. It belongs to the product categories of Organic-Metal Salt; Ion Tests; Special Applications; Test Papers/Sticks. Its EINECS registry number is 206-104-4. With the CAS registry number 301-04-2, its IUPAC name is Lead(II) ethanoate. This chemical, as with any other lead salts, causes lead poisoning. It is made by treating lead(II) oxide with acetic acid.

Physical properties of Lead acetate: (1)H-Bond Donor: 0; (2)H-Bond Acceptor: 4; (3)Rotatable Bond Count: 0; (4)Exact Mass: 326.003245; (5)MonoIsotopic Mass: 326.003245; (6)Topological Polar Surface Area: 80.3; (7)Heavy Atom Count: 9; (8)Formal Charge: 0; (9)Complexity: 25.5; (10)Isotope Atom Count: 0; (11)Defined Atom StereoCenter Count: 0; (12)Undefined Atom StereoCenter Count: 0; (13)Defined Bond StereoCenter Count: 0; (14)Undefined Bond StereoCenter Count: 0; (15)Covalently-Bonded Unit Count: 3.

Uses of Lead acetate: the substance is used as a reagent to make other lead compounds and as a fixative for some dyes. In low concentrations, it is the principal active ingredient in progressive types of hair coloring dyes. Lead(II) acetate is also used as a mordant in textile printing and dyeing, as a drier in paints and varnishes, and in preparing other lead compounds.

When you are using this chemical, please be cautious about it as the following:
This chemical that at low levels can cause damage to health. It may present an immediate or delayed danger to one or more components of the environment. In addition, it is very toxic to aquatic organisms which may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). If swallowed, you should not induce vomiting: seek medical advice immediately and show this container or label.

You can still convert the following datas into molecular structure:
(1)SMILES: CC(=O)[O-].CC(=O)[O-].[PbH2+2]
(2)InChI: InChI=1/2C2H4O2.Pb.2H/c2*1-2(3)4;;;/h2*1H3,(H,3,4);;;/q;;+2;;/p-2/r2C2H4O2.H2Pb/c2*1-2(3)4;/h2*1H3,(H,3,4);1H2/q;;+2/p-2
(3)InChIKey: NJJJCKUBWUKYFT-QYNWPUPPAA

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo intravenous 300mg/kg (300mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
dog LDLo oral 300mg/kg (300mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo subcutaneous 80mg/kg (80mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo subcutaneous 1600mg/kg (1600mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
human LDLo oral 714mg/kg (714mg/kg) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
man TDLo intravenous 71mg/kg (71mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

BLOOD: NORMOCYTIC ANEMIA
Human Toxicology. Vol. 4, Pg. 301, 1985.
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Toxicology. Vol. 64, Pg. 19, 1990.
mouse LD50 intravenous 104mg/kg (104mg/kg)   Igaku to Seibutsugaku. Medicine and Biology. Vol. 93, Pg. 461, 1977.
pigeon LDLo intraperitoneal 150mg/kg (150mg/kg)   Archives of Toxicology. Vol. 46, Pg. 265, 1980.
rabbit LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 301, 1949.
rabbit LDLo subcutaneous 300mg/kg (300mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.