Products Categories
Basic Information
| CAS No.: | 303-81-1 |
|---|---|
| Name: | Novobiocin |
| Article Data: | 9 |
| Molecular Structure: | |
|
|
|
| Formula: | C31H36 N2 O11 |
| Molecular Weight: | 612.634 |
| Synonyms: | Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-(9CI); Coumarin, 7-[4-(carbamoyloxy)tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-(6CI); Novobiocin (8CI); Albamix; Albamycin; Antibiotic PA-93; Cardelmycin;Cathocin; Cathomycin; Crystallinic acid; Inamycin; Novo-R; PA 93; Robiocina; Sirbiocina;Spheromycin; Stilbiocina; Streptonivicin; U 6391 |
| Density: | 1.42g/cm3 |
| Melting Point: | 170-172 °C |
| Boiling Point: | 848.2°Cat760mmHg |
| Flash Point: | 466.8°C |
| Hazard Symbols: | May have damaging side effects. |
| Safety: | Poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by unspecified route: conjunctiva irritation and skin dermatitis. Human mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also cause the development of resistant strains of staphylococcus. Used as a food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals; also permitted in food for human consumption. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 200.01000 |
| LogP: | 4.40040 |
Related products
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- Total:28 Page 1 of 1 1
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 303-81-1
Novobiocin
Chemistry
Formula: C31H36N2O11 
Mol. mass: 612.624
Mol. mass: 612.624
Uses
STREPTONIVICIN (303-81-1) may be used to differentiate from the other coagulase-negative Staphylococcus saprophyticus, which is resistant to novobiocin, in culture.
STREPTONIVICIN (303-81-1) is effective antistaphylococcal agent used in the treatment of MRSA.
STREPTONIVICIN (303-81-1) is effective antistaphylococcal agent used in the treatment of MRSA.
Production
The 3-dimethylallyl-4-hydroxybenzoic acid moiety, known as ring A, is derived from prephenate and dimethylallyl pyrophosphate. The aminocoumarin moiety, known as ring B, is derived from L-Tyrosine. The final component of STREPTONIVICIN (303-81-1) is the sugar derivative L-noviose, known as ring C, which is derived from glucose-1-phosphate. Rings A, B, and C are coupled together and modified to give the finished STREPTONIVICIN (303-81-1) molecule.
Toxicity Data With Reference
| 1. | mmo-esc 200 mg/L | NATUAS Nature. 271 (1978),385. | ||
| 2. | pic-esc 10 µg/plate | CNREA8 Cancer Research. 43 (1983),2819. | ||
| 3. | dni-hmn:emb 600 mmol/L | CRNGDP Carcinogenesis. 3 (1982),1171. | ||
| 4. | cyt-mus-par 50 mg/kg | NULSAK Nucleus (Calcutta). 2 (1971),161. | ||
| 5. | dnr-ham:oth 200 mg/L | CRNGDP Carcinogenesis. 5 (1984),187. | ||
| 6. | unr-hmn TDLo:171 mg/kg/12D-C:EYE,SKN | 85ERAY Antibiotics: Origin, Nature, and Properties. 1 (1978),137. | ||
| 7. | orl-mus LD50:1500 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 6 (1981),338. | ||
| 8. | ipr-mus LD50:262 mg/kg | 85FZAT Index of Antibiotics from Actinomycetes Umezawa, H., et al., eds.,Tokyo, Japan.: University of Tokyo Press,1967,471. | ||
| 9. | ivn-mus LD50:407 mg/kg | 85FZAT Index of Antibiotics from Actinomycetes Umezawa, H., et al., eds.,Tokyo, Japan.: University of Tokyo Press,1967,471. |
Safety Profile
STREPTONIVICIN (303-81-1) is poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by unspecified route: conjunctiva irritation and skin dermatitis. Human mutation data reported. An antibiotic with serious side effects which include liver and blood disease. STREPTONIVICIN (303-81-1) may also cause the development of resistant strains of staphylococcus. Used as a food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals; also permitted in food for human consumption. When heated to decomposition it emits toxic fumes of NOx.