Products Categories
CAS No.: | 30356-07-1 |
---|---|
Name: | (S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C17H23 N O |
Molecular Weight: | 257.376 |
Synonyms: | Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-(p-methoxybenzyl)-, (-)- (8CI); Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-, (S)-;(S)-1,2,3,4,5,6,7,8-Octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline |
Density: | 1.07g/cm3 |
Boiling Point: | 394.8°Cat760mmHg |
Flash Point: | 165.6°C |
PSA: | 21.26000 |
LogP: | 3.79900 |
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-1-(4-methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-amine
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With acetic acid; hydrazine In ethanol at 50℃; for 12h; | 81% |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere; | 81% |
With acetic acid; hydrazine In ethanol at 50℃; for 12h; Inert atmosphere; | 81% |
(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With ammonia borane; oxygen In aq. phosphate buffer at 35℃; under 760.051 Torr; for 72h; pH=7.5; Reagent/catalyst; Enzymatic reaction; stereoselective reaction; | 80% |
With (S)-Mandelic acid In water; toluene at 75 - 80℃; for 1h; |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With D-glucose; NADP In dimethyl sulfoxide at 25℃; for 18h; pH=9; Kinetics; Reagent/catalyst; Temperature; pH-value; Solvent; Inert atmosphere; Enzymatic reaction; enantioselective reaction; | 74% |
(+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Stage #1: (+/-)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline hydrobromide With sodium hydroxide In water; toluene Stage #2: With acetic acid In toluene at 20℃; for 0.166667h; Stage #3: With (S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline acetate In toluene at 10℃; for 2h; Temperature; | 30.3% |
2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline
A
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline
B
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 80℃; for 10h; Yields of byproduct given. Title compound not separated from byproducts; |
4-((S)-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
With methanol; toluene |
1,2,3,4,5,6,7,8-octahydroisoquinoline
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 48 h / 85 °C 2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: Cu2O / toluene / 16 h / Heating 2: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 3: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper(I) oxide / toluene / 16 h / Reflux 2: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C / Inert atmosphere 3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: copper(I) oxide / toluene / 16 h / Reflux 2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere 3: hydrazine; acetic acid / ethanol / 12 h / 50 °C / Inert atmosphere View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: toluene / 48 h / 85 °C 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: Cu2O / toluene / 16 h / Heating 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |
(1S)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: toluene / 48 h / 85 °C 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: 18-crown-6, KOH / tetrahydrofuran / 48 h / Heating 2: Cu2O / toluene / 16 h / Heating 3: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C 4: 81 percent / hydrazine, AcOH / aq. ethanol / 12 h / 50 °C View Scheme |