Products Categories
| CAS No.: | 30652-11-0 |
|---|---|
| Name: | 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE |
| Article Data: | 22 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H9NO2 |
| Molecular Weight: | 139.154 |
| Synonyms: | 4(1H)-Pyridone,3-hydroxy-1,2-dimethyl- (8CI);1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone;1,2-Dimethyl-3-hydroxypyridin-4-one;1,2-Dimethyl-3-hydroxypyridine-4-one;3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone;3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;3-Hydroxy-1,2-dimethyl-4-pyridinone;3-Hydroxy-1,2-dimethyl-4-pyridone;APO 66;CGP 37391;CP 20 (chelatingagent);DN 18001AF;Deferiprone;Ferriprox;L 1 (chelatingagent); |
| EINECS: | 212-783-8 |
| Density: | 1.225 g/cm3 |
| Melting Point: | 272-275 °C(lit.) |
| Boiling Point: | 232.7 °C at 760 mmHg |
| Flash Point: | 94.5 °C |
| Solubility: | soluble in hot water |
| Appearance: | White needles |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 42.23000 |
| LogP: | 0.39930 |
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- 90037-22-2
1,2-dimethyl-3-(benzyloxy)-4(1H)-pyridinone
- 30652-11-0
deferiprone
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol for 2h; | 80% |
| With hydrogen; palladium on activated charcoal In tetrahydrofuran under ambient conditions; | 65% |
| With concentrated hydrobromic acid |
| Conditions | Yield |
|---|---|
| In water for 10h; Reflux; | 69% |
| In water at 160 - 162℃; under 6750.5 Torr; for 0.0216667h; Irradiation; | 65% |
| In water for 6.5h; Heating; | 60% |
| Conditions | Yield |
|---|---|
| In water for 20h; Heating; | 64% |
- 82756-28-3
3-(β-D-galactopyranosyloxy)-2-furanyl methyl ketone
- 74-89-5
methylamine
- 30652-11-0
deferiprone
| Conditions | Yield |
|---|---|
| In water for 20h; Heating; | 49% |
| Conditions | Yield |
|---|---|
| With potassium hydroxide In water at 50℃; | 25% |
- 30652-11-0
deferiprone
| Conditions | Yield |
|---|---|
| With (C2H5)3N In methanol; dichloromethane (C2H5)3N added to a soln. of Co complex, a soln. of ligand in MeOH added, stirred at room temp. overnight under N2; evapd. (vac.), dissolved in C6H6, filtered, crystd. by diffusion of the soln. with pentane; elem. anal.; | 98% |
- 30652-11-0
deferiprone
- 100-21-0
terephthalic acid
- 7732-18-5
water
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
| Conditions | Yield |
|---|---|
| at 100℃; for 72h; Sealed tube; High pressure; | 98% |
| Conditions | Yield |
|---|---|
| In methanol; water addn. of soln. of tantalum compd. in methanol to soln. of deferiprone inmethanol, stirring at room temp. overnight, addn. of water, stirring fo r 30 min; evapn. at 40°C, washing with warm CHCl3, filtration, drying in vac., elem. anal.; | 97% |
| Conditions | Yield |
|---|---|
| With NaOCH3 In methanol; water byproducts: NaCl; (N2); reflux (3 h); solvent removal, dissoln. (CH2Cl2), filtration (Celite), evapn.; elem. anal.; | 93% |
- 30652-11-0
deferiprone
- 333-27-7
methyl trifluoromethanesulfonate
| Conditions | Yield |
|---|---|
| In chloroform for 3h; Heating; | 90% |
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Chemistry
Chemical Name: 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
IUPAC NAME: 3-Hydroxy-1,2-dimethylpyridin-4-one
CAS No.: 30652-11-0
RTECS: UU7785940
Molecular Formula: C7H9NO2
Molecular Weight: 139.15 g/mol
Melting Point: 272-275 °C(lit.)
Density: 1.225 g/cm3
Flash Point: 94.5 °C
Boiling Point: 232.7 °C at 760 mmHg
Following is the structure of 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):
Product Categories about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0) are API intermediates ; Chelating Agents, Ligands ; Chelating Agents & Ligands ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Building Blocks ; Heterocyclic Building Blocks ; Piperidones
The chemical synonymous of 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0) are L1 ; Dmhp ; Deferidone ; Deferipron ; Deferiprone ; Cp20 ; 3-Hydroxy-1,2-Dimethyl-4(1h)Pyridinone ; 3-Hydroxy-1,2-Dimethyl-4(1h)-Pyridone
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | BioMetals. Vol. 10, Pg. 247, 1997. |
| mammal (species unspecified) | LD50 | unreported | > 1gm/kg (1000mg/kg) | Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996. | |
| mouse | LD50 | intraperitoneal | 983mg/kg (983mg/kg) | Blood. Vol. 76, Pg. 2389, 1990. | |
| rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Drugs of the Future. Vol. 13, Pg. 413, 1988. | |
| rat | LD50 | oral | 2gm/kg (2000mg/kg) | CARDIAC: OTHER CHANGES | Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996. |
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes:
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Risk Statements about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):
R22 Harmful if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about 1,2-Dimethyl-3-hydroxy-4-pyridone (30652-11-0):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 Wear suitable gloves and eye/face protection.
Attentions:
1. Storage: Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.