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CAS No.: | 31251-41-9 |
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Name: | 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C14H10ClNO |
Molecular Weight: | 243.692 |
Synonyms: | 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-one; |
EINECS: | 700-257-5 |
Density: | 1.314 g/cm3 |
Melting Point: | 90-92 °C |
Boiling Point: | 433.614 °C at 760 mmHg |
Flash Point: | 216.042 °C |
Appearance: | Yellow solid |
Hazard Symbols: | Xi |
PSA: | 29.96000 |
LogP: | 3.06460 |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h; Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux; | 94% |
With PPA at 200℃; | 45% |
With PPA Heating; |
3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.166667h; | 91% |
With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.166667h; | 78% |
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
With water at 0 - 35℃; for 25 - 35h; | 76.4% |
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
With aluminum (III) chloride In carbon disulfide | 40% |
2-iodoyl-3,5-dichlorobenzoic acid
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 121 g / (MeO)3B; BH3*Me2S / tetrahydrofuran / 18 h / 20 °C 2.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C 3.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 4.1: NaH / dimethylformamide / 1 h / 0 °C 4.2: 10 g / dimethylformamide / 0.25 h / 0 °C 5.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme |
5-chloro-2-iodobenzyl alcohol
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C 2.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 3.1: NaH / dimethylformamide / 1 h / 0 °C 3.2: 10 g / dimethylformamide / 0.25 h / 0 °C 4.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme |
2-(bromomethyl)-4-chloro-1-iodobenzene
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C 2.1: NaH / dimethylformamide / 1 h / 0 °C 2.2: 10 g / dimethylformamide / 0.25 h / 0 °C 3.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme |
3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: 10 g / dimethylformamide / 0.25 h / 0 °C 2.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C View Scheme |
N-tert-butyl-3-methylpyridine-2-carboxamide
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: PPA / Heating View Scheme |
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: POCl3 / Heating 2: PPA / Heating View Scheme |
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Molecular structure of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (CAS NO.31251-41-9) is:
Product Name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
CAS Registry Number: 31251-41-9
Systematic Name: 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Empirical Formula: C14H10ClNO
Molecular Weight: 243.6883
Melting Point: 90-92°C
Index of Refraction: 1.632
Molar Refractivity: 66.136 cm3
Molar Volume: 185.481 cm3
Surface Tension: 53.838 dyne/cm
Density: 1.314 g/cm3
Flash Point: 216.042 °C
Enthalpy of Vaporization: 68.959 kJ/mol
Boiling Point: 433.614 °C at 760 mmHg
Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Intermediates
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (CAS NO.31251-41-9) can be used as loratadine intermediate.
Hazard Codes: Xi
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one , its cas register number is 31251-41-9. It also can be called 8-Chloro-10,11-Dihydro-4-Aza-5h-Dibenzo-(A,D)Cycloheptan-5-One ; 8-Chloro-5,6-Dihydro-11h-Benzo-(5,6)-Cyclohepta-(1,2-B)-Pyrimidine-11-On ; 8-Chloro-10,11-dihydro-4-aza-5 ; 4-Aza-8-chloro-10,11-dihydro-5H-benzo[a,d]cyclo-5-heptanone .It is a yellow solid.