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| CAS No.: | 31252-42-3 |
|---|---|
| Name: | 4-BENZYLPIPERIDINE |
| Article Data: | 22 |
| Molecular Structure: | |
|
|
|
| Formula: | C12H17N |
| Molecular Weight: | 175.274 |
| Synonyms: | Piperidine,4-benzyl- (6CI,7CI,8CI);4-(Phenylmethyl)piperidine;4-Benzylpiperidine;NSC30346; |
| EINECS: | 250-535-0 |
| Density: | 0.969 g/cm3 |
| Melting Point: | 6-7 °C(lit.) |
| Boiling Point: | 279.6 °C at 760 mmHg |
| Flash Point: | 125.4 °C |
| Appearance: | CLEAR COLOURLESS TO YELLOW VISCOUS LIQUID |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 12.03000 |
| LogP: | 2.55750 |
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- 852475-26-4MC1568
- 205641-99-2
4-benzyl-1-[(4-methylphenyl)sulfonyl]piperidine
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| Stage #1: 4-benzyl-1-[(4-methylphenyl)sulfonyl]piperidine With Na/K absorbed into silica gel In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With water In tetrahydrofuran | 96% |
| 92% | |
| With dimethyl(phenyl)silyl lithium In tetrahydrofuran at 0℃; | 78% |
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; cetyltrimethylammonim bromide at 20℃; for 14h; | 96% |
- 544478-05-9
4-benzyl-N-tritylpiperidine
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| Stage #1: 4-benzyl-N-tritylpiperidine With naphthalene; lithium In tetrahydrofuran at 0℃; for 1h; Stage #2: With water In tetrahydrofuran at 0 - 20℃; | 91% |
- 15104-07-1
1-nitroso-4-(phenylmethyl)piperidine
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; titanium tetrachloride In 1,2-dimethoxyethane for 14h; Ambient temperature; | 90% |
| With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran for 6h; Ambient temperature; | 90% |
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| With naphthalene; lithium In tetrahydrofuran; methanol at 20℃; for 5h; | 89% |
- 132251-82-2
4-benzyl-1-(methanesulfonyl)piperidine
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| Stage #1: 4-benzyl-1-(methanesulfonyl)piperidine With Na/K absorbed into silica gel In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With water In tetrahydrofuran | 89% |
| Product distribution / selectivity; | 83% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; platinum Hydrogenation; |
- 2116-65-6
4-benzyl pyridine
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| With ethanol; sodium | |
| With acetic acid; platinum Hydrogenation; | |
| With nickel at 100℃; under 110326 - 220652 Torr; Hydrogenation; | |
| With platinum(IV) oxide; hydrogen In acetic acid at 20℃; under 2585.81 Torr; for 12h; | |
| Stage #1: 4-benzyl pyridine With hydrogen; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In octane at 120℃; under 15001.5 Torr; for 40h; Stage #2: With water Catalytic behavior; chemoselective reaction; | > 99 %Chromat. |
- 31252-42-3
4-benzylpyperidine
| Conditions | Yield |
|---|---|
| With naphthalene; lithium In tetrahydrofuran at 0℃; for 1h; | 95 % Chromat. |
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Chemistry
IUPAC Name: Piperidine, 4-(phenylmethyl)-
The MF of Piperidine, 4-(phenylmethyl)- (31252-42-3) is C12H17N.
The MW of Piperidine, 4-(phenylmethyl)- (31252-42-3) is 175.27.
Synonyms of Piperidine, 4-(phenylmethyl)- (31252-42-3): 4-Benzylpiperidine ; Piperidine, 4- (phenylmethyl)- ; 4-(Phenylmethyl)piperidine ; 4-Benzyl-piperidine ; Phenyl(4-piperidyl)methane ; Piperidine, 4-benzyl-
Product Categories: Piperidine;Piperidine Series
Form: clear colourless to yellow viscous liquid
Index of Refraction: 1.526
EINECS: 250-535-0
Density: 0.969 g/ml
Flash Point: 125.4 °C
Boiling Point: 279.6 °C
Melting Point: 6-7 °C
BRN: 132339
Uses
Piperidine, 4-(phenylmethyl)- (31252-42-3) is used as pharmaceutical Intermediates.
Production
Treatment of 2,5-dihydroxybenzoic acid (I) with dimethyl sulfate and K2CO3 afforded methyl 2-hydroxy-5-methoxybenzoate (II). Condensation of (II) with dimethylthiocarbamoyl chloride gave the O-aryl thiocarbamate (III), which underwent thermal rearrangement to the S-aryl isomer (IV) upon heating at 265 C in diphenyl ether. Subsequent hydrolysis of the thiocarbamate group of (IV) furnished the desired thiophenol compound (V). Cyclization of the mercapto ester (V) with 2-chloroethylamine (VI) gave rise to the benzothiazepinone (VII), which was further reduced to the benzothiazepine (VIII) using LiAlH4. Acylation of (VIII) with acryloyl chloride (IX) provided the acrylamide (X). Finally, Michael addition of 4-benzylpiperidine (XI) to acrylamide (X) yielded the title compound.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01587, |
Safety Profile
Safety information of Piperidine, 4-(phenylmethyl)- (31252-42-3):
Hazard Codes 
Xi
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany 3
RTECS TM4728000
Hazard Note Irritant