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Basic Information
| CAS No.: | 31430-18-9 |
|---|---|
| Name: | NOCODAZOLE |
| Article Data: | 3 |
| Molecular Structure: | |
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|
|
| Formula: | C14H11N3O3S |
| Molecular Weight: | 301.326 |
| Synonyms: | 2-Benzimidazolecarbamicacid, 5-(2-thenoyl)-, methyl ester (8CI);Carbamic acid,[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester (9CI);Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester;NSC 238159;Oncodazole;R 17934; |
| EINECS: | 250-626-5 |
| Density: | 1.491 g/cm3 |
| Melting Point: | 300 °C (dec.) |
| Solubility: | DMSO: 10 mg/mL, soluble |
| Appearance: | Amber powder |
| Hazard Symbols: |
 T,  C,  F
|
| Risk Codes: | 61-40-36/37/38-34-11 |
| Safety: | 53-45-36/37/39-26 |
| Transport Information: | UN 2811 |
| PSA: | 112.32000 |
| LogP: | 3.10670 |
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NOCODAZOLE
Chemistry
MF: C14H11N3O3S
MW: 301.32
EINECS: 250-626-5
mp: 300 °C (dec.)
storage temp: 2-8°C
solubility DMSO: 10 mg/mL, soluble
form: powder
color: white
Synonyms:[5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE;NOCODAZOLE;R 17934
Molecular Structure:
MW: 301.32
EINECS: 250-626-5
mp: 300 °C (dec.)
storage temp: 2-8°C
solubility DMSO: 10 mg/mL, soluble
form: powder
color: white
Synonyms:[5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE;NOCODAZOLE;R 17934
Molecular Structure:
Uses
ONCODAZOLE is used as a synthetic chemotherapeutic agent with antineoplastic, antifungal and anthelmintic activities. Microtubule inhibitor; inhibits mitosis.
Toxicity Data With Reference
| 1. | sln-smc 1 ppm/16H | MUREAV Mutation Research. 141 (1984),15. | ||
| 2. | cyt-hmn:hla 40 µg/L | CNREA8 Cancer Research. 36 (1976),905. | ||
| 3. | ipr-mus LD50:39,350 µg/kg | NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . |
Safety Profile
Poison by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx. See also CARBAMATES.
Hazard Codes T,C,F
Risk Statements 61-40-36/37/38-34-11
Safety Statements 53-45-36/37/39-26-16
RIDADR 2811
WGK Germany 3
RTECS DD6521000
HazardClass 6.1(b)
PackingGroup III
Hazard Codes T,C,F
Risk Statements 61-40-36/37/38-34-11
Safety Statements 53-45-36/37/39-26-16
RIDADR 2811
WGK Germany 3
RTECS DD6521000
HazardClass 6.1(b)
PackingGroup III
Specification
Handling and Storage of ONCODAZOLE:
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a dry area. Deep freeze (below -20°C).